Cardiogenic brain embolism and lupus anticoagulant
Department of Neurology
Adult; Blood Coagulation Factors; Brain Ischemia; Echocardiography; Embolism; Heart Diseases; Humans; Intracranial Embolism and Thrombosis; Lupus Coagulation Inhibitor; Male
Cardiology | Medical Immunology | Neurology
The lupus anticoagulant, an acquired immunoglobulin associated with an increased tendency for thrombosis, has been linked to the occurrence of cerebral ischemia presumably related to in situ thrombosis. Cardioembolic cerebral ischemic events have rarely been reported. We encountered 2 patients with focal cerebral ischemia, substantial mitral valvular masses, and a circulating lupus anticoagulant. In each, diagnostic evaluation supported a cardioembolic etiology. These findings illustrate the need for evaluating patients with cerebral ischemic events for a cardioembolic source when a circulating lupus anticoagulant is present.
DOI of Published Version
Ann Neurol. 1989 Sep;26(3):390-2. Link to article on publisher's site
Annals of neurology
Young, Seymour M.; Fisher, Marc; Sigsbee, Ann; and Errichetti, Annmarie, "Cardiogenic brain embolism and lupus anticoagulant" (1989). Neurology Publications and Presentations. 140.