Title
Atherosclerosis: current concepts on pathogenesis and interventional therapies
UMMS Affiliation
Department of Neurology
Publication Date
1989-07-01
Document Type
Article
Subjects
Arteriosclerosis; Cerebrovascular Disorders; Cholesterol; Diet; Female; Humans; Lipoproteins; Male
Disciplines
Nervous System Diseases | Neurology
Abstract
Atherosclerosis, the primary pathological condition accounting for most stroke syndromes, has been the intense focus of epidemiological, basic, and clinical investigations. Since these studies have direct bearing on the prevention of atherothrombotic brain infarction, this review emphasizes those advances in treatment resulting from their findings. The two most prominent theories on the pathogenesis of atherosclerosis relate to aberrations in lipoprotein metabolism and to enhanced proliferation of smooth muscle cells; likely, the theories are complementary. As a practical guideline for preventive therapy, the importance of using the total cholesterol level is stressed, although finer distinctions must rely on the low-density and high-density lipoprotein concentrations and their normalization. Since prevention of stroke may ultimately be its most effective therapy, consideration of cholesterol level, akin to strategies for preventing coronary heart disease, and efforts to avert platelet adhesion or aggregation and coagulation are warranted.
DOI of Published Version
10.1002/ana.410260102
Source
Ann Neurol. 1989 Jul;26(1):3-12. Link to article on publisher's site
Journal/Book/Conference Title
Annals of neurology
Related Resources
PubMed ID
2673002
Repository Citation
Yatsu, Frank M. and Fisher, Marc, "Atherosclerosis: current concepts on pathogenesis and interventional therapies" (1989). Neurology Publications and Presentations. 139.
https://escholarship.umassmed.edu/neuro_pp/139