Title

Atherosclerosis: current concepts on pathogenesis and interventional therapies

UMMS Affiliation

Department of Neurology

Publication Date

1989-07-01

Document Type

Article

Subjects

Arteriosclerosis; Cerebrovascular Disorders; Cholesterol; Diet; Female; Humans; Lipoproteins; Male

Disciplines

Nervous System Diseases | Neurology

Abstract

Atherosclerosis, the primary pathological condition accounting for most stroke syndromes, has been the intense focus of epidemiological, basic, and clinical investigations. Since these studies have direct bearing on the prevention of atherothrombotic brain infarction, this review emphasizes those advances in treatment resulting from their findings. The two most prominent theories on the pathogenesis of atherosclerosis relate to aberrations in lipoprotein metabolism and to enhanced proliferation of smooth muscle cells; likely, the theories are complementary. As a practical guideline for preventive therapy, the importance of using the total cholesterol level is stressed, although finer distinctions must rely on the low-density and high-density lipoprotein concentrations and their normalization. Since prevention of stroke may ultimately be its most effective therapy, consideration of cholesterol level, akin to strategies for preventing coronary heart disease, and efforts to avert platelet adhesion or aggregation and coagulation are warranted.

DOI of Published Version

10.1002/ana.410260102

Source

Ann Neurol. 1989 Jul;26(1):3-12. Link to article on publisher's site

Journal/Book/Conference Title

Annals of neurology

Related Resources

Link to article in PubMed

PubMed ID

2673002

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