Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain

UMMS Affiliation

Department of Neurology; Department of Radiology; Graduate School of Biomedical Sciences

Publication Date


Document Type



Animals; Brain; Cerebral Cortex; Diffusion; *Magnetic Resonance Spectroscopy; Male; Potassium Chloride; Rats; Rats, Sprague-Dawley; Sodium Chloride; *Spreading Cortical Depression


Neurology | Radiology


A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading depression (SD) was elicited in rats by topical application of potassium chloride to the exposed cortex. The apparent diffusion coefficient (Dapp) of water in a region of the cortex, measured using a PFG-NMR spin echo sequence with an observation time of 40 ms, declines 35% within 30 s and recovers to the normal value within the next 30 s. The region of decreased Dapp was shown to be 2 mm in size and to move in the cortex, away from the point of application, with a uniform velocity of 3.3 +/- 0.5 mm/min. The behavior of the affected region is consistent with other reports of the behavior of SD as monitored by electrophysiological means. The technique can be implemented on currently available MRI equipment and makes possible the noninvasive study of SD in animal models of neurological disorders, their therapeutic intervention, and possibly the study of SD in humans.


Magn Reson Med. 1994 Aug;32(2):189-98.

Journal/Book/Conference Title

Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine

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Link to article in PubMed

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