Title

Tissue plasminogen activator reduces neurological damage after cerebral embolism

UMMS Affiliation

Department of Neurology

Publication Date

1985-12-13

Document Type

Article

Subjects

Animals; Cerebrovascular Disorders; Disease Models, Animal; Intracranial Embolism and Thrombosis; Rabbits; Time Factors; Tissue Plasminogen Activator

Disciplines

Nervous System Diseases | Neurology | Pharmacy and Pharmaceutical Sciences

Abstract

Intravenous administration of tissue plasminogen activator immediately after the injection of numerous small blood clots into the carotid circulation in rabbit embolic stroke model animals caused a significant reduction in neurological damage. In vitro studies indicate that tissue plasminogen activator produced substantial lysis of clots at concentrations comparable to those expected in vivo, suggesting that this may be the mechanism of action of this drug. Drug-induced hemorrhages were not demonstrable. Tissue plasminogen activator may be of value for the immediate treatment of embolic stroke.

Source

Science. 1985 Dec 13;230(4731):1289-92.

Journal/Book/Conference Title

Science (New York, N.Y.)

Related Resources

Link to article in PubMed

PubMed ID

3934754

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