Tissue plasminogen activator reduces neurological damage after cerebral embolism
Department of Neurology
Animals; Cerebrovascular Disorders; Disease Models, Animal; Intracranial Embolism and Thrombosis; Rabbits; Time Factors; Tissue Plasminogen Activator
Nervous System Diseases | Neurology | Pharmacy and Pharmaceutical Sciences
Intravenous administration of tissue plasminogen activator immediately after the injection of numerous small blood clots into the carotid circulation in rabbit embolic stroke model animals caused a significant reduction in neurological damage. In vitro studies indicate that tissue plasminogen activator produced substantial lysis of clots at concentrations comparable to those expected in vivo, suggesting that this may be the mechanism of action of this drug. Drug-induced hemorrhages were not demonstrable. Tissue plasminogen activator may be of value for the immediate treatment of embolic stroke.
Science. 1985 Dec 13;230(4731):1289-92.
Science (New York, N.Y.)
Zivin, Justin A.; Fisher, Marc; DeGirolami, Umberto; Hemenway, Carl C.; and Stashak, Joan A., "Tissue plasminogen activator reduces neurological damage after cerebral embolism" (1985). Neurology Publications and Presentations. 120.