Title
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats
UMMS Affiliation
Department of Neurology; Graduate School of Biomedical Sciences
Publication Date
2007-10
Document Type
Article
Subjects
Animals; Diffusion; Infarction, Middle Cerebral; Artery; Magnetic Resonance Imaging; Male; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Software
Disciplines
Neurology
Abstract
Almost no data is available on the serial changes in the brain after spectacular shrinking deficit (SSD) that may help understand this relatively rare clinical phenomenon. Quantitative diffusion-(DWI), perfusion-(PWI), T(1)-(T1WI), T(2)-weighted (T2WI), and functional magnetic resonance imaging (fMRI) were performed before, during, and up to 7 days after embolic middle cerebral artery occlusion (eMCAO) in male Sprague-Dawley rats (n=9). Region of interest (ROI) analysis was used to evaluate structural and functional MR signal changes within three ROIs defined by the apparent diffusion coefficient (ADC), cerebral blood flow (CBF) signatures, and final tissue viability. DWI, PWI, and T2WI lesion volumes were calculated using previously established viability thresholds and final infarct volumes ascertained with 2,3,5-triphenyltetrazolium chloride (TTC) staining. Serial MRI demonstrated spontaneous reperfusion of initially hypoperfused MCA regions accompanied by substantial reduction of initial ADC and CBF lesions and gradual recovery of neurological outcome. Recovery rates of CBF/ADC abnormalities differed among ROIs. Functional magnetic resonance imaging showed persistent tissue dysfunction after the recovery of the CBF/ADC lesions. This study may facilitate our understanding of the pathophysiological mechanisms by which early, spontaneous reperfusion affects tissue fate and neurological function.
DOI of Published Version
10.1038/sj.jcbfm.9600477
Source
J Cereb Blood Flow Metab. 2007 Oct;27(10):1756-63. Epub 2007 Mar 21. Link to article on publisher's site
Journal/Book/Conference Title
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Related Resources
PubMed ID
17377514
Repository Citation
Henninger, Nils; Sicard, Kenneth M.; and Fisher, Marc, "Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats" (2007). Neurology Publications and Presentations. 116.
https://escholarship.umassmed.edu/neuro_pp/116