This collection showcases journal articles and other publications and presentations written by faculty and researchers of the Department of Neurology.

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Publications from 2019

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A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Chantal M. Ferguson, Dimas Echeverria, Ellen Sapp, Reka A. Haraszti, Andrew H. Coles, Faith Conroy, Rachael Miller, Loic Roux, Paul Yan, Emily G. Knox, Anton A. Turanov, Robert M. King, Gwladys Gernoux, Christian Mueller, Heather Gray-Edwards, Richard P. Moser, N Bishop, Samer M. Jaber, Matthew J. Gounis, Miguel Sena-Esteves, Athma A. Pai, Marian DiFiglia, Neil Aronin, and Anastasia Khvorova

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Defective daily temperature regulation in a mouse model of amyotrophic lateral sclerosis, Maurine C. Braun, Alexandra Castillo-Ruiz, Premananda Indic, Dae Young Jung, Jason K. Kim, Robert H. Brown Jr., Steven J. Swoap, and William J. Schwartz

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Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis, Johnathan Cooper-Knock, John E. Landers, and Pamela J. Shaw

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Correction of pseudoexon splicing caused by a novel intronic dysferlin mutation, Janice A. Dominov, Ozgun Uyan, Diane McKenna-Yasek, Babi Ramesh Reddy Nallamilli, Virginie Kergourlay, Marc Bartoli, Nicolas Levy, Judith Hudson, Teresinha Evangelista, Hanns Lochmuller, Martin Krahn, Laura Rufibach, Madhuri Hegde, and Robert H. Brown Jr.

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Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1, Vera Fridman, Saranya Suriyanarayanan, Peter Novak, William David, Eric A. Macklin, Diane McKenna-Yasek, Kailey Walsh, Razina Aziz-Bose, Anne Louise Oaklander, Robert H. Brown Jr., Thorsten Hornemann, and Florian Eichler

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Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis, Anthony Giampetruzzi, Eric W. Danielson, Valentina Gumina, Maryangel Jeon, Sivakumar Boopathy, Robert H. Brown Jr., Antonia Ratti, John E. Landers, and Claudia Fallini

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A pilot study evaluating a simple cardiac dysfunction score to predict complications and survival among critically-ill patients with traumatic brain injury, Patric W. Gibbons, Robert J. Goldberg, and Susanne Muehlschlegel

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The neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are independently associated with neurological disability and brain atrophy in multiple sclerosis, Christopher C. Hemond, Bonnie I. Glanz, Rohit Bakshi, Tanuja Chitnis, and Brian C. Healy

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Precise therapeutic gene correction by a simple nuclease-induced double-stranded break, Sukanya Iyer, Sneha Suresh, Dongsheng Guo, Katelyn Daman, Jennifer C. J. Chen, Pengpeng Liu, Marina Zieger, Kevin Luk, Benjamin P. Roscoe, Christian Mueller, Oliver D. King, Charles P. Emerson Jr., and Scot A. Wolfe

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Mutations in the SPTLC1 gene are a cause of amyotrophic lateral sclerosis that may be amenable to serine supplementation, Janel O. Johnson, Ruth Chia, Robert H. Brown Jr., and John E. Landers

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Impact of age on cerebral aneurysm occlusion after flow diversion, Anna Luisa Kuhn, Peter Kan, Nils Henninger, Visish Srinivasan, Katyucia de Macedo Rodrigues, Ajay K. Wakhloo, Matthew J. Gounis, and Ajit S. Puri

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Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis, Yvonne L. Latour, Robin Yoon, Sarah E. Thomas, Christina Grant, Cuiling Li, Miguel Sena-Esteves, Maria L. Allende, Richard L. Proia, and Cynthia J. Tifft

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Potential use of leukocytosis and anion gap elevation in differentiating psychogenic nonepileptic seizures from epileptic seizures, Yi Li, Liesl Matzka, Julie Flahive, and Daniel Weber

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Reduction in apathy following epilepsy surgery, Linda Mah, Joan M. Swearer, Catherine A. Phillips, and Sheldon Benjamin

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A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia, Tyler Picariello, Jason M. Brown, Yuqing Hou, Gregory Swank, Deborah A. Cochran, Oliver D. King, Karl Lechtreck, Gregory J. Pazour, and George B. Witman

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Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1, Shilpa Prabhakar, Pike See Cheah, Xuan Zhang, Max Zinter, Maria Gianatasio, Eloise Hudry, Roderick T. Bronson, David J. Kwiatkowski, Anat Stemmer-Rachamimov, Casey A. Maguire, Miguel Sena-Esteves, Bakhos A. Tannous, and Xandra O. Breakefield

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Sensory dysphagia: A case series and proposed classification of an under recognized swallowing disorder, Laura F. Santoso, Daniel Y. Kim, and David Paydarfar

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The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing, Maeve Tischbein, Desiree M. Baron, Yen-Chen Lin, Katherine V. Gall, John E. Landers, Claudia Fallini, and Daryl A. Bosco

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gMS-Classifier1 does not predict disability progression in multiple sclerosis, Johannis A. van Rossum, Joep Killestein, Luisa M. Villar, Peter N. Riskind, Mark S. Freedman, and Charlotte Teunissen

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Gap Analysis Regarding Prognostication in Neurocritical Care: A Joint Statement from the German Neurocritical Care Society and the Neurocritical Care Society, Katja E. Wartenberg, David Y. Hwang, Karl Georg Haeusler, Susanne Muehlschlegel, Oliver W. Sakowitz, Dominik Madzar, Hajo M. Hamer, Alejandro A. Rabinstein, David M. Greer, J. Claude Hemphill 3rd, Juergen Meixensberger, and Panayiotis N. Varelas

Publications from 2018

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Cerebral organoids derived from Sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation, Maria L. Allende, Emily K. Cook, Bridget C. Larman, Adrienne Nugent, Jacqueline M. Brady, Diane Golebiowski, Miguel Sena-Esteves, Cynthia J. Tifft, and Richard L. Proia

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Safe and effective superoxide dismutase 1 silencing using artificial microRNA in macaques, Florie Borel, Gwladys Gernoux, Huaming Sun, Rachel Stock, Meghan Blackwood, Robert H. Brown Jr., and Christian Mueller

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Time management in a co-housed social rodent species (Arvicanthis niloticus), Alexandra Castillo-Ruiz, Premananda Indic, and William J. Schwartz

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Evolution of extrema features reveals optimal stimuli for biological state transitions, Joshua TsuKang Chang and David Paydarfar

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C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2alpha phosphorylation, Weiwei Cheng, Shaopeng Wang, Alexander A. Mestre, Chenglai Fu, Andres Makarem, Fengfan Xian, Lindsey R. Hayes, Rodrigo Lopez-Gonzalez, Kevin Drenner, Jie Jiang, Don W. Cleveland, and Shuying Sun

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Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro, Jen-Chieh Chiang, Jun Jiang, Peter E. Newburger, and Jeanne B. Lawrence

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Evaluation of a Novel Preference Assessment Tool for Patients with Multiple Sclerosis, Nananda F. Col, Andrew J. Solomon, Vicky Springmann, Carolina Ionete, Enrique Alvarez, Brenda Tierman, Christen Kutz, Idanis M. Berrios Morales, Carolyn Griffin, Long H. Ngo, David E. Jones, Glenn Phillips, Ashli Hopson, and Lori Pbert

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ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function, Martina de Majo, Kevin P. Kenna, Robert H. Brown Jr., John E. Landers, and Christopher E. Shaw

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Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin, Marie C. Didiot, Chantal M. Ferguson, Socheata Ly, Andrew H. Coles, Abigail O. Smith, Alicia A. Bicknell, Lauren M. Hall, Ellen Sapp, Dimas Echeverria, Athma A. Pai, Marian DiFiglia, Melissa J. Moore, Lawrence J. Hayward, Neil Aronin, and Anastasia Khvorova

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"Don't lose hope early": Hemorrhagic diffuse axonal injury on head computed tomography is not associated with poor outcome in moderate to severe traumatic brain injury patients, Nils Henninger, Rebecca A. Compton, Muhammad W. Khan, Raphael A. Carandang, Wiley R. Hall, and Susanne Muehlschlegel

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Breastfeeding History and Risk of Stroke Among Parous Postmenopausal Women in the Women's Health Initiative, Lisette T. Jacobson, Erinn M. Hade, Tracie C. Collins, Karen L. Margolis, Molly E. Waring, Linda V. Van Horn, Brian Silver, Maryam Sattari, Chloe E. Bird, Kim Kimminau, Karen Wambach, and Marcia L. Stefanick

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Systemic Delivery of AAVB1-GAA Clears Glycogen and Prolongs Survival in a Mouse Model of Pompe Disease, Allison M. Keeler, Marina Zieger, Sophia H. Todeasa, Angela L. McCall, Jennifer C. Gifford, Samantha Birsak, Sourav Roy Choudhury, Barry J. Byrne, Miguel Sena-Esteves, and Mai K. Elmallah

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Recent Trends in Oral Anticoagulant Use and Post-Discharge Complications Among Atrial Fibrillation Patients with Acute Myocardial Infarction, Amartya Kundu, Kevin O. Day, Darleen M. Lessard, Joel M. Gore, Hong Yu, Mohammed W. Akhter, Daniel Z. Fisher, Robert M. Hayward Jr, Nils Henninger, Alok Kapoor, Jorge L. Yarzebski, Robert J. Goldberg, and David D. McManus

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A Standard Nomenclature for Referencing and Authentication of Pluripotent Stem Cells, Andreas Kurtz, Stefanie Seltmann, and Kelly P. Smith

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Ephrinb3 modulates hippocampal neurogenesis and the reelin signaling pathway in a pilocarpineinduced model of epilepsy, Tian-Tian Liu, Yi Li, Yi Shu, Bo Xiao, and Li Feng

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Atrial fibrillation is associated with anterior predominant white matter lesions in patients presenting with embolic stroke, Yunis M. Mayasi, Johanna Helenius, David D. McManus, Richard P. Goddeau Jr, Adalia H. Jun-O'Connell, Majaz Moonis, and Nils Henninger

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Should We Use the IMPACT-Model for the Outcome Prognostication of TBI Patients? A Qualitative Study Assessing Physicians' Perceptions, Jesse Moskowitz, Thomas Quinn, Muhammad W. Khan, Lori Shutter, Robert J. Goldberg, Nananda Col, Kathleen M. Mazor, and Susanne Muehlschlegel

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Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs, Maire F. Osborn, Andrew H. Coles, Diane Golebiowski, Dimas Echeverria, Michael P. Moazami, Jonathan K. Watts, Miguel Sena-Esteves, and Anastasia Khvorova

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The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1, Maria Perez Carrion, John E. Landers, Stefano Goldwurm, and Giovanni Piccoli

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Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis, Owen M. Peters, Elizabeth A. Lewis, Jeannette M. Osterloh, Alexandra Weiss, Johnny Salameh, Jake P. Metterville, Robert H. Brown Jr., and Marc R. Freeman

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Herpes ICP8 protein stimulates homologous recombination in human cells, Melvys Valledor, Richard S. Myers, and Paul C. Schiller

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Herpes ICP8 protein stimulates homologous recombination in human cells, Melvys Valledor, Richard S. Myers, and Paul C. Schiller

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Inferring dynamic topology for decoding spatiotemporal structures in complex heterogeneous networks, Shuo Wang, Erik D. Herzog, Istvan Z. Kiss, William J. Schwartz, Guy Bloch, Michael Sebek, Daniel Granados-Fuentes, Liang Wang, and Jr-Shin Li

Publications from 2017

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Atrial fibrillation, cognition and dementia: A review, Summer Aldrugh, Mayank Sardana, Nils Henninger, Jane S. Saczynski, and David D. McManus

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Investigating Structural and Functional Defects in ALS-causing Profilin 1 Variants, Sivakumar Boopathy

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The Estimated Verbal GCS Subscore in Intubated Traumatic Brain Injury Patients: Is it Really Better, Katarina Cheng, Ribal Bassil, Raphael A. Carandang, Wiley R. Hall, and Susanne Muehlschlegel

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XIST RNA: a window into the broader role of RNA in nuclear chromosome architecture, Kevin Creamer and Jeanne B. Lawrence

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A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD, Rustam Esanov, Gabriela Toro Cabrera, Nadja S. Andrade, Tania F. Gendron, Robert H. Brown Jr., Michael Benatar, Claes Wahlestedt, Christian Mueller, and Zane Zeier

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Direct Intracranial Injection of AAVrh8 Encoding Monkey beta-N-Acetylhexosaminidase Causes Neurotoxicity in the Primate Brain, Diane Golebiowski, Imramsjah M. J. van der Bom, Churl-Su Kwon, Andrew D. Miller, Keiko Petrosky, Allison M. Bradbury, Stacy A. Maitland, Anna L. Kuhn, Nina Bishop, Elizabeth Curran, Nilsa Silva, Dwijit Guhasarkar, Susan V. Westmoreland, Douglas R. Martin, Matthew J. Gounis, Wael F. Asaad, and Miguel Sena-Esteves

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Lipidomic Evaluation of Feline Neurologic Disease after AAV Gene Therapy, Heather L. Gray-Edwards, Xuntian Jiang, Ashley N. Randle, Amanda R. Taylor, Taylor L. Voss, Aime K. Johnson, Victoria J. McCurdy, Miguel Sena-Esteves, Daniel S. Ory, and Douglas R. Martin

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Intracranial AAV-IFN-beta gene therapy eliminates invasive xenograft glioblastoma and improves survival in orthotopic syngeneic murine model, Dwijit Guhasarkar, James Neiswender, Qin Su, Guangping Gao, and Miguel Sena-Esteves

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Demethylated HSATII DNA and HSATII RNA Foci Sequester PRC1 and MeCP2 into Cancer-Specific Nuclear Bodies, Lisa L. Hall, Meg Byron, Dawn M. Carone, Troy W. Whitfield, Gayle P. Pouliot, Andrew H. Fischer, Peter L. Jones, and Jeanne B. Lawrence

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Inhibiting Axon Degeneration in a Mouse Model of Acute Brain Injury Through Deletion of Sarm1, Nils Henninger

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The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis, Adalia H. Jun-O'Connell, Ankur A. Butala, Idanis Berrios Morales, Nils Henninger, Kristina M. Deligiannidis, Nancy Byatt, and Carolina Ionete

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Endovascular treatment of acute ischemic stroke in nonagenarians compared with younger patients in a multicenter cohort, Muhib A. Khan, Grayson L. Baird, David Miller, Anand Patel, Shawn Tsekhan, Shadi Yaghi, Ajit S. Puri, Mahesh Jayaraman, Nils Henninger, and Brian Silver

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Alberta Stroke Program Early CT Score Infarct Location Predicts Outcome Following M2 Occlusion, Muhib Khan, Grayson L. Baird, Richard P. Goddeau, Brian Silver, and Nils Henninger

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Leukoaraiosis, intracerebral hemorrhage, and functional outcome after acute stroke thrombolysis, Kannikar Kongbunkiat, Duncan Wilson, Narongrit Kasemsap, Somsak Tiamkao, Fatima Jichi, Vanessa Palumbo, Michael D. Hill, Alastair M. Buchan, Simon Jung, Heinrich P. Mattle, Nils Henninger, and David J. Werring

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The lysosomal protein cathepsin L is a progranulin protease, Chris W. Lee, Jeannette N. Stankowski, Jeannie Chew, Casey N. Cook, Ying-Wai Lam, Sandra Almeida, Yari Carlomagno, Kwok-Fai Lau, Mercedes Prudencio, Fen-Biao Gao, Matthew Bogyo, Dennis W. Dickson, and Leonard Petrucelli

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CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion, Haiwei Mou, Jordan L. Smith, Lingtao Peng, Jill Moore, Xiao-Ou Zhang, Chun-Qing Song, Ankur Sheel, Deniz M. Ozata, Yingxiang Li, Charles P. Emerson Jr., Erik J. Sontheimer, Melissa J. Moore, Zhiping Weng, and Wen Xue

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Artificial miRNAs reduce human mutant Huntingtin throughout the striatum in a transgenic sheep model of Huntington's disease, Edith L. Pfister, Natalie Dinardo, Erica Mondo, Florie Borel, Faith Conroy, Gwladys Gernoux, Lori A. Kennington, Richard P. Moser, Miguel Sena-Esteves, Guangping Gao, Christian Mueller, and Neil Aronin

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A general neurologist's perspective on the urgent need to apply resilience thinking to the prevention and treatment of Alzheimer's disease, Grazyna Pomorska and Judith K. Ockene

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Project MinE: study design and pilot analyses of a large-scale whole-genome sequencing study in amyotrophic lateral sclerosis, Project MinE Consortium, Wouter Van Rheenen, Kevin P. Kenna, John E. Landers, and Jan H. Veldink

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What Families Need and Physicians Deliver: Contrasting Communication Preferences Between Surrogate Decision-Makers and Physicians During Outcome Prognostication in Critically Ill TBI Patients, Thomas Quinn, Jesse Moskowitz, Muhammad A. Khan, Lori Shutter, Robert J. Goldberg, Nananda Col, Kathleen M. Mazor, and Susanne Muehlschlegel

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ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation, Reddy Ranjith Kumar Sama, Claudia Fallini, Rodolfo Gatto, Jeanne E. McKeon, Yuyu Song, Melissa S. Rotunno, Saul Penaranda, Izrail Abdurakhmanov, John E. Landers, Gerardo Morfini, Scott T. Brady, and Daryl Bosco

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Targeted Genetic Screen in Amyotrophic Lateral Sclerosis Reveals Novel Genetic Variants with Synergistic Effect on Clinical Phenotype, Pamela J. Shaw, Kevin P. Kenna, and John E. Landers

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RAHI-SATHI Indo-U.S. Collaboration: The Evolution of a Trainee-Led Twinning Model in Global Health Into a Multidisciplinary Collaborative Program, Apurv Soni, Nisha Fahey, Abraham Jaffe, Tiffany A. Moore Simas, Nancy Byatt, Michael Chin, David D. McManus, Michaela Tracey, Jasmine A. Khubchandani, Haley Newman, Allison Earon, Hannah Rosenfield, Anna Handorf, Brittany Novak, John Bostrom, Anindita Deb, Milagros C. Rosal, Patricia A. McQuilkin, Heena Santry, Melissa A. Fischer, and Jeroan J. Allison

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Restrictive Lung Disease in the Cu/Zn Superoxide-Dismutase 1 G93A Amyotrophic Lateral Sclerosis Mouse Model, Lorelei Stoica, Allison M. Keeler, Lang Xiong, Michael Kalfopoulos, Kaitlyn Desrochers, Robert H. Brown Jr., Miguel Sena-Esteves, Terence R. Flotte, and Mai K. Elmallah

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Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs, Feng Wang, Kurtis N. McCannell, Ana Boskovic, Xiaochun Zhu, JongDae Shin, Jun Yu, Judith Gallant, Meg Byron, Jeanne B. Lawrence, Lihua Julie Zhu, Stephen N. Jones, Oliver J. Rando, Thomas G. Fazzio, and Ingolf Bach

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Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients, Shanye Yin, Rodrigo Lopez-Gonzalez, Ryan C. Kunz, Jaya Gangopadhyay, Carl Borufka, Steven P. Gygi, Fen-Biao Gao, and Robin Reed

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Vibrotactile stimulation: A non-pharmacological intervention for opioid-exposed newborns, Ian Zuzarte, Premananda Indic, Bruce A. Barton, David Paydarfar, Francis Bednarek, and Elisabeth B. Salisbury

Publications from 2016

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The Modified Apnea Test During Brain Death Determination: An Alternative in Patients With Hypoxia, Aditi Ahlawat, Raphael A. Carandang, Stephen O. Heard, and Susanne Muehlschlegel

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MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations, Md Helal Uddin Biswas, Sandra Almeida, Rodrigo Lopez-Gonzalez, Wenjie Mao, Zhijun Zhang, Anna M. Karydas, Michael D. Geschwind, Jacek Biernat, Eva-Maria Mandelkow, Kensuke Futai, Bruce L. Miller, and Fen-Biao Gao

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Phase III Preclinical Trials in Translational Stroke Research: Community Response on Framework and Guidelines, Johannes Boltze, Daniel-Christoph Wagner, Nils Henninger, Nikolaus Plesnila, and Cenk Ayata

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Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1(G93A) Mice and Nonhuman Primates, Florie Borel, Gwladys Gernoux, Brynn Cardozo, Jake P. Metterville, Gabriela Toro Cabrera, Lina Song, Qin Su, Guang Ping Gao, Mai K. Elmallah, Robert H. Brown Jr., and Christian Mueller

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Wearable Biosensors to Detect Physiologic Change During Opioid Use, Stephanie Carreiro, Kelley Wittbold, Premananda Indic, Hua (Julia) Fang, Jianying Zhang, and Edward W. Boyer

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Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics, Jennifer C. J. Chen, Oliver D. King, Yuanfan Zhang, Nicholas P. Clayton, Carrie Spencer, Bruce M. Wentworth, Charles P. Emerson Jr., and Kathryn R. Wagner (Molecular therapy : the journal of the American Society of Gene Therapy)

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Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector, Sourav Roy Choudhury, Anne F. Harris, Damien J. Cabral, Allison M. Keeler, Jennifer Ferreira, Qin Su, Lorelei Stoica, Neil Aronin, Guangping Gao, and Miguel Sena-Esteves

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In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy, Sourav Roy Choudhury, Anne F. Harris, Stacy A. Maitland, Jennifer Ferreira, Shan Ma, Rohit B. Sharma, Laura C. Alonso, Claudio Punzo, Robert M. Kotin, and Miguel Sena-Esteves

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Anticonvulsive Effects of Licofelone on Status Epilepticus Induced by Lithium-pilocarpine in Wistar Rats: a Role for Inducible Nitric Oxide Synthase, Seyyed Majid Eslami, Mohammad Mobin Moradi, Mehdi Ghasemi, and Ahmad Reza Dehpour

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ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics, Jozsef Gal, Lisha Kuang, Kelly R. Barnett, Brian Z. Zhu, Susannah C. Shissler, Konstantin V. Korotkov, Lawrence J. Hayward, Edward J. Kasarskis, and Haining Zhu

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Impact of Leukoaraiosis Burden on Hemispheric Lateralization of the National Institutes of Health Stroke Scale Deficit in Acute Ischemic Stroke, Johanna Helenius, Richard P. Goddeau, Majaz Moonis, and Nils Henninger

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Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1, Nils Henninger, James P. Bouley, Elif M. Sikoglu, Jiyan An, Constance M. Moore, Jean A. King, Robert Bowser, Marc R. Freeman, and Robert H. Brown Jr.

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Extending the Time Window for Endovascular and Pharmacological Reperfusion, Nils Henninger and Marc Fisher

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Atrial Fibrillation Is Associated With a Worse 90-Day Outcome Than Other Cardioembolic Stroke Subtypes, Nils Henninger, Richard P. Goddeau, Ameeta Karmarkar, Johanna Helenius, and David D. McManus

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CRISPR/dCas9-mediated transcriptional inhibition ameliorates the epigenetic dysregulation at D4Z4 and represses DUX4-fl in FSH muscular dystrophy, Charis L. Himeda, Takako I. Jones, and Peter L. Jones

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NEK1 variants confer susceptibility to amyotrophic lateral sclerosis, Kevin P. Kenna, Perry T. C. van Doormaal, Annelot M. Dekker, Nicola Ticozzi, Brendan J. Kenna, Pamela J. Keagle, Aoife Kenna, Claudia Fallini, Peter C. Sapp, Diane McKenna-Yasek, Robert H. Brown Jr., Vincenzo Silani, Christopher E. Shaw, Leonard H. van den Berg, Jan H. Veldink, and John E. Landers

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), Daniel J. Klionsky, Roger J. Davis, Fen-Biao Gao, and Panagiotis D. Velentzas

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The importance of rare diseases for psychiatry, Margo D. Lauterbach, Barbara Schildkrout, Sheldon Benjamin, and Michael D. Gregory

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ARTS (Aspiration-Retriever Technique for Stroke): Initial clinical experience, Francesco Massari, Nils Henninger, Juan Diego Lozano, Anand Patel, Anna L. Kuhn, Mary Howk, Mary Perras, Christopher Brooks, Matthew J. Gounis, Peter Kan, Ajay K. Wakhloo, and Ajit S. Puri

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Newer Oral Anticoagulants: Stroke Prevention and Pitfalls, Anand Patel, Richard P. Goddeau, and Nils Henninger

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White Matter Hyperintensity-Adjusted Critical Infarct Thresholds to Predict a Favorable 90-Day Outcome, Jatinder Patti, Johanna Helenius, Ajit S. Puri, and Nils Henninger

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Multimodal Learning and Intelligent Prediction of Symptom Development in Individual Parkinson's Patients, Andrzej W. Przybyszewski, Mark Kon, Stanislaw Szlufik, Artur Szymanski, Piotr Habela, and Dariusz M. Koziorowski

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Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration, Jihae Shin, Johnny S. Salameh, and Joel D. Richter

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Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability, M. Catarina Silva, Sandra Almeida, Md Helal Uddin Biswas, Zhijun Zhang, Fen-Biao Gao, and Stephen J. Haggarty

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Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model, Lorelei Stoica, Sophia H. Todeasa, Gabriela Toro Cabrera, Johnny Salameh, Mai K. Elmallah, Christian Mueller, Robert H. Brown Jr., and Miguel Sena-Esteves

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A Novel Protocol for Directed Differentiation of C9orf72-Associated Human Induced Pluripotent Stem Cells Into Contractile Skeletal Myotubes, Elliot W. Swartz, Jaeyun Baek, Mochtar Pribadi, Kevin J. Wojta, Sandra Almeida, Anna M. Karydas, Fen-Biao Gao, Bruce L. Miller, and Giovanni Coppola

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Design of shRNA and miRNA for Delivery to the CNS, Gabriela Toro Cabrera and Christian Mueller

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Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice, Petr Vodicka, Kathryn O. Chase, Maria Iuliano, Adelaide Tousley, Dana T. Valentine, Ellen Sapp, Kimberly B. Kegel-Gleason, Miguel Sena-Esteves, Neil Aronin, and Marian DiFiglia

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CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia, Kelly L. Williams, Jason Kost, Robert H. Brown Jr., John E. Landers, and Ian P. Blair

Publications from 2015

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Structural basis for mutation-induced destabilization of profilin 1 in ALS, Sivakumar Boopathy, Tania V. Silvas, Maeve Tischbein, Silvia Jansen, Shivender Shandilya, Jill A. Zitzewitz, John E. Landers, Bruce L. Goode, Celia A. Schiffer, and Daryl A. Bosco