Understanding signal transduction during bacterial infection
Department of Molecular Genetics and Microbiology
Animals; Bacterial Proteins; Bordetella Infections; Gene Expression Regulation, Bacterial; Humans; *Signal Transduction; Transcription Factors
Microbiology | Molecular Genetics
Many known or suspected bacterial virulence factors require environmentally responsive control factors for expression. In Bordetella species, the BvgAS system represses and activates sets of genes, and mediates a biphasic phenotypic transition. Studies using mutants with altered signaling pathways and reversed regulatory connections have provided insights into the role of BvgAS and this phenotypic transition during the Bordetella-host interaction.
Trends Microbiol. 1996 Apr;4(4):141-6.
Trends in microbiology
Akerley BJ, Miller JF. (1996). Understanding signal transduction during bacterial infection. Molecular Genetics and Microbiology Publications. Retrieved from https://escholarship.umassmed.edu/mgm_pp/24