Statin discontinuation in nursing home residents with advanced dementia
Meyers Primary Care Institute; Department of Quantitative Health Sciences
Aged; Aged, 80 and over; Alzheimer Disease; Cohort Studies; Comorbidity; Dementia; Disease Progression; Drug Substitution; Drug Utilization; Female; *Homes for the Aged; Hospice Care; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; *Medical Futility; Mental Status Schedule; *Nursing Homes; Odds Ratio; Retrospective Studies; United States
Cardiovascular Diseases | Geriatrics | Mental and Social Health | Mental Disorders | Psychiatry and Psychology
OBJECTIVES: To describe patterns of, and factors associated with, statin use and discontinuation in nursing home (NH) residents progressing to advanced dementia and followed for at least 90 days.
DESIGN: Retrospective inception cohort using a dataset linking 2007 to 2008 Minimum Data Set (MDS) to Medicare denominator and Part D files.
SETTING: All NHs in five states (Minnesota, Massachusetts, Pennsylvania, California, Florida).
PARTICIPANTS: NH residents with dementia.
MEASUREMENTS: Residents who developed advanced dementia were observed from baseline (date of progression to very severe cognitive impairment with eating problems) and followed for at least 90 days to statin discontinuation or death. Logistic regression was used to identify baseline factors associated with statin use. Cox proportional hazard regression was used to identify factors associated with time to statin discontinuation.
RESULTS: Of 10,212 residents, 16.6% (n = 1,699) used statins. Greater odds of statin use were associated with having diabetes mellitus (adjusted odds ratio (AOR) = 1.24, 95% confidence interval (CI) = 1.09-1.40), stroke (AOR = 1.31, 95% CI = 1.16-1.48), and hypertension (AOR = 1.35, 95% CI = 1.18-1.54); hospice enrollment was associated with lower odds (AOR = 0.75, 95% CI = 0.64-0.89). In follow-up, 37.2% (n = 632) discontinued statins. Median time to discontinuation was 36 days (interquartile range 12-110 days). Shorter time to discontinuation was associated with hospitalization in past 30 days (adjusted hazard ratio (AHR) = 1.67, 95% CI = 1.40-1.99) and more daily medications (AHR = 1.02, 95% CI = 1.01-1.04). When statins were discontinued, 15.0% (n = 95) of residents stopped only statins, and 47.5% (n = 300) stopped at least one other medication.
CONCLUSION: Most NH residents who use statins at the time of progression to advanced dementia continue use in follow-up. Geriatrics Society.
DOI of Published Version
J Am Geriatr Soc. 2014 Nov;62(11):2095-101. doi: 10.1111/jgs.13105. Epub 2014 Nov 4. Link to article on publisher's site
Journal of the American Geriatrics Society
Tjia, Jennifer; Cutrona, Sarah L.; Peterson, Daniel; Reed, George W.; Andrade, Susan E.; and Mitchell, Susan L., "Statin discontinuation in nursing home residents with advanced dementia" (2014). Meyers Primary Care Institute Publications and Presentations. 723.