The Prevalence and Trends of Antiviral Medication Use During Pregnancy in the US: A Population-Based Study of 664,297 Deliveries in 2001-2007
Authors
Avalos, Lyndsay A.Chen, Hong
Yang, Chunmei
Andrade, Susan E.
Cooper, William O.
Cheetham, T. Craig
Davis, Robert L.
Dublin, Sascha
Hammad, Tarek A.
Kaplan, Sigal
Pawloski, Pamala
Raebel, Marsha A.
Scott, Pamela E.
Smith, David H.
Toh, Sengwee
Li, De-Kun
UMass Chan Affiliations
Meyers Primary Care InstituteDocument Type
Journal ArticlePublication Date
2014-01-01Keywords
Antiviral AgentsPregnancy
Maternal Exposure
Virus Diseases
Prevalence
Chemicals and Drugs
Clinical Epidemiology
Health Services Research
Maternal and Child Health
Obstetrics and Gynecology
Women's Health
Metadata
Show full item recordAbstract
To evaluate the prevalence, trends, timing and duration of exposure to antiviral medications during pregnancy within a US cohort of pregnant women and to evaluate the proportion of deliveries with a viral infection diagnosis among women given antiviral medication during pregnancy. Live-born deliveries between 2001 and 2007, to women aged 15-45 years, were included from the Medication Exposure in Pregnancy Risk Evaluation Program, a collaborative research program between the U.S. Food and Drug Administration and eleven health plans. They were evaluated for prevalence, timing, duration, and temporal trends of exposure to antiviral medications during pregnancy. We also calculated the proportion of deliveries with a viral infection diagnosis among those exposed to antiviral medications. Among 664,297 live births, the overall prevalence of antiviral exposure during pregnancy was 4 % (n = 25,155). Between 2001 and 2007, antiviral medication exposure during pregnancy doubled from 2.5 to 5 %. The most commonly used antiviral medication was acyclovir, with 3 % of the deliveries being exposed and most of the exposure occurring after the 1st trimester. Most deliveries exposed to antiviral medications were exposed for less than 30 days (2 % of all live births). Forty percent of the women delivering an infant exposed to antiviral medications had a herpes diagnosis. Our findings highlight the increased prevalence of women delivering an infant exposed to antiviral medications over time. These findings support the need for large, well-designed studies to assess the safety and effectiveness of these medications during pregnancy.Source
Matern Child Health J. 2014 Jan;18(1):64-72. doi: 10.1007/s10995-013-1234-9.. Link to article on publisher's site
DOI
10.1007/s10995-013-1234-9Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37247PubMed ID
23420306Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1007/s10995-013-1234-9