Obesity, weight change, and risk of adenoma recurrence: a prospective trial
Authors
Laiyemo, Adeyinka O.Doubeni, Chyke A.
Badurdeen, Dilhana S.
Murphy, Gillian
Marcus, Pamela M.
Schoen, Robert E.
Lanza, E.
Smoot, Duane T.
Cross, A. J.
UMass Chan Affiliations
Meyers Primary Care InstituteDepartment of Family Medicine and Community Health
Document Type
Journal ArticlePublication Date
2012-09-01Keywords
AdenomaColorectal Neoplasms
Body Weight Changes
Obesity
Community Health and Preventive Medicine
Digestive System Diseases
Neoplasms
Metadata
Show full item recordAbstract
BACKGROUND AND STUDY AIMS: Obesity is a risk factor for colorectal neoplasia. Lifestyle modifications, including weight loss, have been advocated to reduce the risk. However, no prospective study has evaluated whether weight loss actually affects adenoma recurrence. The aim of this study was to examine whether weight change (loss or gain) over 4 years is associated with adenoma recurrence. PATIENTS AND METHODS: A total of 1826 patients with colorectal adenoma in the Polyp Prevention Trial had their height and weight measured at baseline. Adenoma recurrence was determined by end of trial colonoscopy 4 years after study entry when patients' weights were re-measured. Poisson regression models were used to evaluate body mass index (BMI), weight change over 4 years, and the risk of any adenoma and advanced adenoma recurrence. RESULTS: Adenoma recurrence was observed in 723 patients (39.6%), 118 (6.5%) of whom had advanced adenoma recurrence. Among those with baseline BMI < 25 kg/m(2) (n = 466), BMI 25-29 kg/m(2) (n = 868), and BMI >/= 30 kg/m(2) (n = 492), the recurrence rate was 34.5%, 41.0%, and 41.9%, respectively. Obesity was associated with an increased risk of adenoma recurrence (RR = 1.19; 95%CI 1.01-1.39) and advanced adenoma recurrence (RR = 1.62; 95%CI 1.01-2.57). However, when compared with those with relatively stable weight (weight change < 5 lb) over the 4-year trial, weight gain or loss was not associated with adenoma recurrence. This was consistent, regardless of the baseline BMI. CONCLUSIONS: Weight loss or gain over 4 years does not affect adenoma recurrence. This study does not support weight loss alone as an effective intervention for reducing adenoma recurrence.Source
Endoscopy. 2012 Sep;44(9):813-8. doi: 10.1055/s-0032-1309837. Epub 2012 Aug 27. Link to article on publisher's site
DOI
10.1055/s-0032-1309837Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37192PubMed ID
22926666Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1055/s-0032-1309837