Long-term use of medications and destructive periodontal disease

UMMS Affiliation

Meyers Primary Care Institute; Department of Family Medicine and Community Health

Publication Date


Document Type



Alveolar Bone Loss; Anti-Allergic Agents; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Urinary; Antitussive Agents; Chronic Disease; Common Cold; Diabetes Mellitus; Drug Prescriptions; Drug Therapy; Female; Furcation Defects; Histamine H1 Antagonists; Humans; Immunity, Innate; Longitudinal Studies; Male; Middle Aged; Nasal Decongestants; Periodontal Attachment Loss; Periodontal Diseases; Periodontal Pocket; Smoking


Dentistry | Health Services Research | Primary Care


BACKGROUND: Knowledge of typical medication use among patients with chronic periodontitis or destructive periodontal disease is limited. The aim of this study was to associate periodontitis severity with the use of different classes of medications.

METHODS: Patients (N=12,631) who had medical, dental, and pharmaceutical coverage with a health maintenance organization and whose severity of destructive periodontal disease was diagnosed by a dentist or specialist were included in the study. The rate of drug use over 7 years was related to the severity of destructive periodontal disease by means of Poisson regression models. RESULTS: Individuals with moderate to advanced periodontitis had significantly lower fill rates for the respiratory agents (antihistamines: -23%, 95% confidence interval [CI]: -10% to -34%; decongestants: -24%, 95% CI: -13% to -34%; and cough/cold medications: -12%, 95% CI: -3% to -21%) and anti-infective agents (antibiotics: -12%, 95% confidence interval: -6% to -18%; urinary anti-infectives: -36%, 95% CI: -6% to -56%; and topical antibiotics: -18%, 95% CI: -5% to -29%).

CONCLUSIONS: More severe periodontitis was a marker for reduced medication use for allergies and infections. The associations between destructive periodontal disease, infections, allergies, and the hygiene hypothesis need further exploration.

DOI of Published Version



J Periodontol. 2008 Aug;79(8):1330-8. Link to article on publisher's site

Journal/Book/Conference Title

Journal of periodontology

Related Resources

Link to Article in PubMed