Daily medication use in nursing home residents with advanced dementia

UMMS Affiliation

Meyers Primary Care Institute; Department of Medicine, Division of Geriatric Medicine

Publication Date


Document Type



Aged, 80 and over; Antipsychotic Agents; Cholinesterase Inhibitors; Cohort Studies; *Dementia; Female; Humans; Hypolipidemic Agents; Male; *Medication Adherence; *Nursing Homes; Polypharmacy; Prospective Studies; Terminal Care


Geriatrics | Health Services Research | Primary Care


OBJECTIVES: To describe the pattern and factors associated with daily medication use in nursing home (NH) residents with advanced dementia.

DESIGN: Prospective cohort study.

SETTING: Twenty-two Boston-area NHs.

PARTICIPANTS: NH residents with advanced dementia (N=323).

MEASUREMENTS: Data from residents' records were used to determine the number or daily medications, specific drugs prescribed, and use of drugs deemed "never appropriate" in patients with advanced dementia. Resident characteristics associated with the use of more daily medications and drugs deemed inappropriate were examined.

RESULTS: Residents were prescribed a mean of 5.9 +/- 3.0 daily medications, and 37.5% received at least one medication considered "never appropriate" in advanced dementia. Acetylcholinesterase inhibitors (15.8%) and lipid-lowering agents (12.1%) were the most common inappropriate drugs. Twenty-eight percent of residents took antipsychotics daily. Modest reductions in most daily medications occurred only during the last week of life. Factors independently associated with taking more daily medications included older age, male sex, non-white race, dementia not due to Alzheimer's disease, better cognition, cardiovascular disease, acute illness, and hospice referral. Factors independently associated with greater likelihood of taking inappropriate medications included being male, shorter NH stay, better functional status, and diabetes mellitus, whereas a do-not-hospitalize order was associated with a lower likelihood.

CONCLUSION: Questionably beneficial medications are common in advanced dementia, even as death approaches. Several characteristics can help identify residents at risk for greater medication burden. Medication use in advanced dementia should be tailored to the goals of care.

DOI of Published Version



J Am Geriatr Soc. 2010 May;58(5):880-8. Epub 2010 Apr 14. Link to article on publisher's site

Journal/Book/Conference Title

Journal of the American Geriatrics Society

Related Resources

Link to Article in PubMed

PubMed ID