Comparing drug effectiveness at health plans: the ethics of cluster randomized trials
Meyers Primary Care Institute
*Cluster Analysis; Data Collection; Health Facility Administrators; Humans; Informed Consent; Patient Satisfaction; Randomized Controlled Trials as Topic
Health Services Research | Primary Care
"Cluster randomized trials," in which groups of patients are randomly assigned to different therapeutic interventions, provide a powerful way of evaluating drugs. CRTs have not been widely used, in good part because of concerns about whether patients must give informed consent to participate in them. A better understanding of how CRTs fit into clinical practice resolves the concerns.
Hastings Cent Rep. 2008 Sep-Oct;38(5):39-48. Link to article on publisher's website
The Hastings Center report
Sabin, James E.; Mazor, Kathleen M.; Meterko, Vanessa; Goff, Sarah L.; and Platt, Richard, "Comparing drug effectiveness at health plans: the ethics of cluster randomized trials" (2008). Meyers Primary Care Institute Publications and Presentations. 441.