Hormone therapy initiation after the Women's Health Initiative
Meyers Primary Care Institute
Adult; Aged; Cohort Studies; Drug Administration Routes; Drug Administration Schedule; Estrogen Replacement Therapy; Estrogens; Female; Health Maintenance Organizations; Humans; Middle Aged; *Patient Acceptance of Health Care; Progestins; Women's Health
Health Services Research | Primary Care
OBJECTIVES: To describe hormone therapy (HT) initiation after the 2002 publication of the Women's Health Initiative.
DESIGN: Observational cohort (1999-2003) of women ages 40 to 79 years, five health plans, used HT in July 2002 and subsequently discontinued or never used before August 2002.
RESULTS: Of discontinuers, 15.8% (3,203 of 20,205) reinitiated HT. Reinitiation was higher among estrogen users (23.8%) versus estrogen with progestin users (11.3%), and lower among those with diabetes (relative risk [RR]=0.68, 95% CI: 0.61-0.76), cardiovascular disease (RR=0.87, 95% CI: 0.83-0.92), and hyperlipidemia (RR=0.83, 95% CI: 0.79-0.88). Only 2.3% (2,072 of 90,261) of never users initiated (August 2002 to December 2003). First-time initiation was associated with cardiovascular disease (RR=1.17, 95% CI: 1.10-1.25) and hyperlipidemia (RR=1.24, 95% CI: 1.17-1.33) and was less common among those with diabetes (RR=0.70, 95% CI: 0.63-0.79).
CONCLUSIONS: After the Women's Health Initiative, a minority of women reinitiated or became first-time initiators of HT. Women with cardiovascular disease, diabetes, and hyperlipidemia were less likely to reinitiate; women with cardiovascular disease and hyperlipidemia were more likely to be first-time initiators.
DOI of Published Version
Menopause. 2008 May-Jun;15(3):487-93. Link to article on publisher's site
Menopause (New York, N.Y.)
Newton KM, Buist DS, Yu O, Hartsfield CL, Andrade SE, Wei F, Connelly MT, Chan KA. (2008). Hormone therapy initiation after the Women's Health Initiative. Meyers Primary Care Institute Publications. https://doi.org/10.1097/gme.0b013e318154b9a5. Retrieved from https://escholarship.umassmed.edu/meyers_pp/423