Vitamin E and vitamin C supplement use and risk of incident Alzheimer disease.

UMMS Affiliation

Meyers Primary Care Institute

Publication Date


Document Type



Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Ascorbic Acid; Boston; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Incidence; Male; Urban Population; Vitamin E


Geriatrics | Health Services Research | Primary Care


Oxidative stress may play a role in neurologic disease. The present study examined the relation between use of vitamin E and vitamin C and incident Alzheimer disease in a prospective study of 633 persons 65 years and older. A stratified random sample was selected from a disease-free population. At baseline, all vitamin supplements taken in the previous 2 weeks were identified by direct inspection. After an average follow-up period of 4.3 years, 91 of the sample participants with vitamin information met accepted criteria for the clinical diagnosis of Alzheimer disease. None of the 27 vitamin E supplement users had Alzheimer disease compared with 3.9 predicted based on the crude observed incidence among nonusers (p = 0.04) and 2.5 predicted based on age, sex, years of education, and length of follow-up interval (p = 0.23). None of the 23 vitamin C supplement users had Alzheimer disease compared with 3.3 predicted based on the crude observed incidence among nonusers (p = 0.10) and 3.2 predicted adjusted for age, sex, education, and follow-up interval (p = 0.04). There was no relation between Alzheimer disease and use of multivitamins. These data suggest that use of the higher-dose vitamin E and vitamin C supplements may lower the risk of Alzheimer disease.


Alzheimer Dis Assoc Disord. 1998 Sep;12(3):121-6.

Journal/Book/Conference Title

Alzheimer disease and associated disorders

Related Resources

Link to article in PubMed

PubMed ID