Title
Complement-Related Regulates Autophagy in Neighboring Cells
UMMS Affiliation
Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network
Publication Date
6-29-2017
Document Type
Article
Disciplines
Biochemistry | Cell Biology | Cellular and Molecular Physiology | Molecular Biology
Abstract
Autophagy degrades cytoplasmic components and is important for development and human health. Although autophagy is known to be influenced by systemic intercellular signals, the proteins that control autophagy are largely thought to function within individual cells. Here, we report that Drosophila macroglobulin complement-related (Mcr), a complement ortholog, plays an essential role during developmental cell death and inflammation by influencing autophagy in neighboring cells. This function of Mcr involves the immune receptor Draper, suggesting a relationship between autophagy and the control of inflammation. Interestingly, Mcr function in epithelial cells is required for macrophage autophagy and migration to epithelial wounds, a Draper-dependent process. This study reveals, unexpectedly, that complement-related from one cell regulates autophagy in neighboring cells via an ancient immune signaling program.
Keywords
autophagy, complement, immune-receptor signaling, programmed cell death
DOI of Published Version
10.1016/j.cell.2017.06.018
Source
Cell. 2017 Jun 29;170(1):158-171.e8. doi: 10.1016/j.cell.2017.06.018. Link to article on publisher's site
Journal/Book/Conference Title
Cell
Related Resources
PubMed ID
28666117
Repository Citation
Li, Lin; Rodrigues, Frederico S. L. M.; Kary, Christina; Contet, Alicia; Logan, Mary; Baxter, Richard H. G; Wood, Will; and Baehrecke, Eric H., "Complement-Related Regulates Autophagy in Neighboring Cells" (2017). UMass Metabolic Network Publications. 99.
https://escholarship.umassmed.edu/metnet_pubs/99