Complement-Related Regulates Autophagy in Neighboring Cells
Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network
Biochemistry | Cell Biology | Cellular and Molecular Physiology | Molecular Biology
Autophagy degrades cytoplasmic components and is important for development and human health. Although autophagy is known to be influenced by systemic intercellular signals, the proteins that control autophagy are largely thought to function within individual cells. Here, we report that Drosophila macroglobulin complement-related (Mcr), a complement ortholog, plays an essential role during developmental cell death and inflammation by influencing autophagy in neighboring cells. This function of Mcr involves the immune receptor Draper, suggesting a relationship between autophagy and the control of inflammation. Interestingly, Mcr function in epithelial cells is required for macrophage autophagy and migration to epithelial wounds, a Draper-dependent process. This study reveals, unexpectedly, that complement-related from one cell regulates autophagy in neighboring cells via an ancient immune signaling program.
autophagy, complement, immune-receptor signaling, programmed cell death
DOI of Published Version
Cell. 2017 Jun 29;170(1):158-171.e8. doi: 10.1016/j.cell.2017.06.018. Link to article on publisher's site
; Rodrigues, Frederico S. L. M.; Kary, Christina; Contet, Alicia; Logan, Mary; Baxter, Richard H. G; Wood, Will; and Baehrecke, Eric H., "Complement-Related Regulates Autophagy in Neighboring Cells" (2017). UMass Metabolic Network Publications. 99.