New discoveries in the pathogenesis and classification of vitiligo

UMMS Affiliation

Department of Dermatology; UMass Metabolic Network

Publication Date


Document Type



Cellular and Molecular Physiology | Dermatology | Skin and Connective Tissue Diseases


Vitiligo is a common autoimmune disease that progressively destroys melanocytes in the skin, resulting in the appearance of patchy depigmentation. This disfiguring condition frequently affects the face and other visible areas of the body, which can be psychologically devastating. The onset of vitiligo often occurs in younger individuals and progresses for life, resulting in a heavy burden of disease and decreased quality of life. Presentation patterns of vitiligo vary, and recognition of these patterns provides both diagnostic and prognostic clues. Recent insights into disease pathogenesis offer a better understanding of the natural history of the disease, its associations, and potential for future treatments. The first article in this continuing medical education series outlines typical and atypical presentations of vitiligo, how they reflect disease activity, prognosis, and response to treatment. Finally, we discuss disease associations, risk factors, and our current understanding of disease pathogenesis.


chemical leukoderma, confetti depigmentation, halo nevi, leukoderma, segmental vitiligo, vitiligo, vitiligo pathogenesis

DOI of Published Version



J Am Acad Dermatol. 2017 Jul;77(1):1-13. doi: 10.1016/j.jaad.2016.10.048. Link to article on publisher's site

Journal/Book/Conference Title

Journal of the American Academy of Dermatology

Related Resources

Link to Article in PubMed

PubMed ID