Program in Molecular Medicine; UMass Metabolic Network
Biochemistry | Cell Biology | Cellular and Molecular Physiology | Developmental Biology | Molecular Biology
Despite progress in our comprehension of the mechanisms regulating adipose tissue development, the nature of the factors that functionally characterize adipose precursors is still elusive. Defining the early steps regulating adipocyte development is needed for the generation of tools to control adipose tissue size and function. Here, we report the discovery of V-set and transmembrane domain containing 2A (VSTM2A) as a protein expressed and secreted by committed preadipocytes. VSTM2A expression is elevated in the early phases of adipogenesis in vitro and adipose tissue development in vivo. We show that VSTM2A-producing cells associate with the vasculature and express the common surface markers of adipocyte progenitors. Overexpression of VSTM2A induces adipogenesis, whereas its depletion impairs this process. VSTM2A controls preadipocyte determination at least in part by modulating BMP signaling and PPARgamma2 activation. We propose a model in which VSTM2A is produced to preserve and amplify the adipogenic capability of adipose precursors.
3T3-L1, adipogenesis, adipogenic commitment, adipose tissue, cell differentiation, cell signaling, obesity, preadipocyte
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Copyright 2017 The Author(s).
DOI of Published Version
Cell Rep. 2017 Jan 3;18(1):93-106. doi: 10.1016/j.celrep.2016.12.015. Link to article on publisher's site
Secco, Blandine; Lee, Peter L.; Guertin, David A.; and Laplante, Mathieu, "Amplification of Adipogenic Commitment by VSTM2A" (2017). UMass Metabolic Network Publications. 93.
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