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Document Type
Journal ArticlePublication Date
2017-01-03Keywords
3T3-L1adipogenesis
adipogenic commitment
adipose tissue
cell differentiation
cell signaling
obesity
preadipocyte
Biochemistry
Cell Biology
Cellular and Molecular Physiology
Developmental Biology
Molecular Biology
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Show full item recordAbstract
Despite progress in our comprehension of the mechanisms regulating adipose tissue development, the nature of the factors that functionally characterize adipose precursors is still elusive. Defining the early steps regulating adipocyte development is needed for the generation of tools to control adipose tissue size and function. Here, we report the discovery of V-set and transmembrane domain containing 2A (VSTM2A) as a protein expressed and secreted by committed preadipocytes. VSTM2A expression is elevated in the early phases of adipogenesis in vitro and adipose tissue development in vivo. We show that VSTM2A-producing cells associate with the vasculature and express the common surface markers of adipocyte progenitors. Overexpression of VSTM2A induces adipogenesis, whereas its depletion impairs this process. VSTM2A controls preadipocyte determination at least in part by modulating BMP signaling and PPARgamma2 activation. We propose a model in which VSTM2A is produced to preserve and amplify the adipogenic capability of adipose precursors.Source
Cell Rep. 2017 Jan 3;18(1):93-106. doi: 10.1016/j.celrep.2016.12.015. Link to article on publisher's siteDOI
10.1016/j.celrep.2016.12.015Permanent Link to this Item
http://hdl.handle.net/20.500.14038/36726PubMed ID
28052263Notes
Full author list omitted for brevity. For the full list of authors, see article.
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Copyright 2017 The Author(s).Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1016/j.celrep.2016.12.015