Title
Vitiligo Pathogenesis and Emerging Treatments
UMMS Affiliation
Department of Medicine, Division of Dermatology; UMass Metabolic Network
Publication Date
4-1-2017
Document Type
Article
Disciplines
Cellular and Molecular Physiology | Dermatology | Skin and Connective Tissue Diseases
Abstract
The pathogenesis of vitiligo involves interplay between intrinsic and extrinsic melanocyte defects, innate immune inflammation, and T-cell-mediated melanocyte destruction. The goal of treatment is to not only halt disease progression but also promote repigmentation through melanocyte regeneration, proliferation, and migration. Treatment strategies that address all aspects of disease pathogenesis and repigmentation are likely to have greatest efficacy, a strategy that may require combination therapies. Current treatments generally involve nontargeted suppression of autoimmunity, whereas emerging treatments are likely to use a more targeted approach based on in-depth understanding of disease pathogenesis, which may provide higher efficacy with a good safety profile.
Keywords
Autoimmunity, Cellular stress, Chemokines, Melanogenesis, Targeted therapy, Vitiligo
DOI of Published Version
10.1016/j.det.2016.11.014
Source
Dermatol Clin. 2017 Apr;35(2):257-265. doi: 10.1016/j.det.2016.11.014. Link to article on publisher's site
Journal/Book/Conference Title
Dermatologic clinics
Related Resources
PubMed ID
28317534
Repository Citation
Rashighi, Medhi and Harris, John E., "Vitiligo Pathogenesis and Emerging Treatments" (2017). UMass Metabolic Network Publications. 76.
https://escholarship.umassmed.edu/metnet_pubs/76