Title
Cleaning House: Selective Autophagy of Organelles
UMMS Affiliation
Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network
Publication Date
2017-04-10
Document Type
Article
Disciplines
Biochemistry | Cell Biology | Cellular and Molecular Physiology | Molecular Biology
Abstract
The selective clearance of organelles by autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. Removal of damaged organelles clears the cell of potentially toxic byproducts and enables reuse of organelle components for bioenergetics. Thus, defects in organelle clearance may be detrimental to the health of the cells, contributing to cancer, neurodegeneration, and inflammatory diseases. Organelle-specific autophagy can clear mitochondria, peroxisomes, lysosomes, ER, chloroplasts, and the nucleus. Here, we review our understanding of the mechanisms that regulate the clearance of organelles by autophagy and highlight gaps in our knowledge of these processes.
DOI of Published Version
10.1016/j.devcel.2017.02.016
Source
Dev Cell. 2017 Apr 10;41(1):10-22. doi: 10.1016/j.devcel.2017.02.016. Link to article on publisher's site
Journal/Book/Conference Title
Developmental cell
Related Resources
PubMed ID
28399394
Repository Citation
Anding, Allyson L. and Baehrecke, Eric H., "Cleaning House: Selective Autophagy of Organelles" (2017). UMass Metabolic Network Publications. 72.
https://escholarship.umassmed.edu/metnet_pubs/72