Integrating the UPRmt into the mitochondrial maintenance network
Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network
Biochemistry | Cell Biology | Cellular and Molecular Physiology | Molecular Biology
Mitochondrial function is central to many different processes in the cell, from oxidative phosphorylation to the synthesis of iron-sulfur clusters. Therefore, mitochondrial dysfunction underlies a diverse array of diseases, from neurodegenerative diseases to cancer. Stress can be communicated to the cytosol and nucleus from the mitochondria through many different signals, and in response the cell can effect everything from transcriptional to post-transcriptional responses to protect the mitochondrial network. How these responses are coordinated have only recently begun to be understood. In this review, we explore how the cell maintains mitochondrial function, focusing on the mitochondrial unfolded protein response (UPRmt), a transcriptional response that can activate a wide array of programs to repair and restore mitochondrial function.
Mitochondrial unfolded protein response, integrated stress response, mitochondria quality control, mitochondrial dysfunction, mitochondrial stress response
DOI of Published Version
Crit Rev Biochem Mol Biol. 2017 Jun;52(3):304-313. doi: 10.1080/10409238.2017.1291577. Epub 2017 Feb 22. Link to article on publisher's site
Critical reviews in biochemistry and molecular biology
Fiorese, Christopher J. and Haynes, Cole M., "Integrating the UPRmt into the mitochondrial maintenance network" (2017). UMass Metabolic Network Publications. 63.