Cardiometabolic disease in South Asians: A global health concern in an expanding population

UMMS Affiliation

Department of Medicine, Division of Cardiovascular Medicine; UMass Metabolic Network

Publication Date


Document Type



Biochemistry | Cardiology | Cardiovascular Diseases | Cell Biology | Cellular and Molecular Physiology | Molecular Biology


Cardiovascular disease (CVD) is one of the main causes of mortality and morbidity worldwide. As an emerging population, South Asians (SAs) bear a disproportionately high burden of CVD relative to underlying classical risk factors, partly attributable to a greater prevalence of insulin resistance and diabetes and distinct genetic and epigenetic influences. While the phenotypic distinctions between SAs and other ethnicities in CVD risk are becoming increasingly clear, the biology of these conditions remains an area of active investigation, with emerging studies involving metabolism, genetic variation and epigenetic modifiers (e.g., extracellular RNA). In this review, we describe the current literature on prevalence, prognosis and CVD risk in SAs, and provide a landscape of translational research in this field toward ameliorating CVD risk in SAs.

DOI of Published Version



Nutr Metab Cardiovasc Dis. 2017 Jan;27(1):32-40. doi: 10.1016/j.numecd.2016.08.001. Epub 2016 Aug 6. Link to article on publisher's site

Journal/Book/Conference Title

Nutrition, metabolism, and cardiovascular diseases : NMCD

Related Resources

Link to Article in PubMed

PubMed ID