Cardiometabolic disease in South Asians: A global health concern in an expanding population
Department of Medicine, Division of Cardiovascular Medicine; UMass Metabolic Network
Biochemistry | Cardiology | Cardiovascular Diseases | Cell Biology | Cellular and Molecular Physiology | Molecular Biology
Cardiovascular disease (CVD) is one of the main causes of mortality and morbidity worldwide. As an emerging population, South Asians (SAs) bear a disproportionately high burden of CVD relative to underlying classical risk factors, partly attributable to a greater prevalence of insulin resistance and diabetes and distinct genetic and epigenetic influences. While the phenotypic distinctions between SAs and other ethnicities in CVD risk are becoming increasingly clear, the biology of these conditions remains an area of active investigation, with emerging studies involving metabolism, genetic variation and epigenetic modifiers (e.g., extracellular RNA). In this review, we describe the current literature on prevalence, prognosis and CVD risk in SAs, and provide a landscape of translational research in this field toward ameliorating CVD risk in SAs.
DOI of Published Version
Nutr Metab Cardiovasc Dis. 2017 Jan;27(1):32-40. doi: 10.1016/j.numecd.2016.08.001. Epub 2016 Aug 6. Link to article on publisher's site
Nutrition, metabolism, and cardiovascular diseases : NMCD
Das, A.; Ambale-Venkatesh, B.; Lima, J. A. C.; Freedman, Jane E.; Spahillari, A.; Das, R.; Das, S.; Shah, R. V.; and Murthy, V. L., "Cardiometabolic disease in South Asians: A global health concern in an expanding population" (2017). UMass Metabolic Network Publications. 5.