Cardiometabolic disease in South Asians: A global health concern in an expanding population
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Authors
Das, A.Ambale-Venkatesh, B.
Lima, J. A. C.
Freedman, Jane E.
Spahillari, A.
Das, R.
Das, S.
Shah, R. V.
Murthy, V. L.
UMass Chan Affiliations
UMass Metabolic NetworkDepartment of Medicine, Division of Cardiovascular Medicine
Document Type
Journal ArticlePublication Date
2017-01-01Keywords
BiochemistryCardiology
Cardiovascular Diseases
Cell Biology
Cellular and Molecular Physiology
Molecular Biology
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Show full item recordAbstract
Cardiovascular disease (CVD) is one of the main causes of mortality and morbidity worldwide. As an emerging population, South Asians (SAs) bear a disproportionately high burden of CVD relative to underlying classical risk factors, partly attributable to a greater prevalence of insulin resistance and diabetes and distinct genetic and epigenetic influences. While the phenotypic distinctions between SAs and other ethnicities in CVD risk are becoming increasingly clear, the biology of these conditions remains an area of active investigation, with emerging studies involving metabolism, genetic variation and epigenetic modifiers (e.g., extracellular RNA). In this review, we describe the current literature on prevalence, prognosis and CVD risk in SAs, and provide a landscape of translational research in this field toward ameliorating CVD risk in SAs.Source
Nutr Metab Cardiovasc Dis. 2017 Jan;27(1):32-40. doi: 10.1016/j.numecd.2016.08.001. Epub 2016 Aug 6. Link to article on publisher's siteDOI
10.1016/j.numecd.2016.08.001Permanent Link to this Item
http://hdl.handle.net/20.500.14038/36681PubMed ID
27612985Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.numecd.2016.08.001