Intergenerational Transfer of Epigenetic Information in Sperm
Department of Biochemistry and Molecular Pharmacology; UMass Metabolic Network
Cell Biology | Cellular and Molecular Physiology | Genetics | Molecular Genetics
The inheritance of information beyond DNA sequence, known as epigenetic inheritance, has been implicated in a multitude of biological processes from control of plant flowering time to cancer in humans. In addition to epigenetic inheritance that occurs in dividing cells of a multicellular organism, it is also increasingly clear that at least some epigenetic information is transmitted via the gametes in a multitude of organisms, including mammals. Here, I review the evidence for epigenetic information carriers in mammalian sperm, and explore the emerging field of intergenerational transfer of environmental information.
DOI of Published Version
Cold Spring Harb Perspect Med. 2016 May 2;6(5). pii: a022988. 10.1101/cshperspect.a022988. Link to article on publisher's site
Cold Spring Harbor perspectives in medicine
Rando, Oliver J., "Intergenerational Transfer of Epigenetic Information in Sperm" (2016). UMass Metabolic Network Publications. 44.