UMMS Affiliation

Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network; School of Medicine; Senior Scholars Program

Publication Date

2017-01-01

Document Type

Letter to the Editor

Disciplines

Biochemistry | Cancer Biology | Cell Biology | Cellular and Molecular Physiology | Molecular Biology

Abstract

Here we show that CK2 inhibition by CX-4945 destabilizes NOTCH1 and synergizes with JQ1 to induce apoptosis in human T-ALL cells, implicating an alternative strategy to target NOTCH1 signaling in refractory/relapsed T-ALL.

Rights and Permissions

Copyright © Ferrata Storti Foundation. Haematologica is an open access journal. Publisher pdf posted as allowed by author guidelines at http://www.haematologica.org/information-for-authors.

DOI of Published Version

10.3324/haematol.2016.154013

Source

Haematologica. 2017 Jan;102(1):e17-e21. doi: 10.3324/haematol.2016.154013. Epub 2016 Oct 6. Link to article on publisher's site

Journal/Book/Conference Title

Haematologica

Comments

Kevin Charles Tang participated in this study as a medical student as part of the Senior Scholars research program at the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

27758824

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