UMMS Affiliation
Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network; School of Medicine; Senior Scholars Program
Publication Date
2017-01-01
Document Type
Letter to the Editor
Disciplines
Biochemistry | Cancer Biology | Cell Biology | Cellular and Molecular Physiology | Molecular Biology
Abstract
Here we show that CK2 inhibition by CX-4945 destabilizes NOTCH1 and synergizes with JQ1 to induce apoptosis in human T-ALL cells, implicating an alternative strategy to target NOTCH1 signaling in refractory/relapsed T-ALL.
Rights and Permissions
Copyright © Ferrata Storti Foundation. Haematologica is an open access journal. Publisher pdf posted as allowed by author guidelines at http://www.haematologica.org/information-for-authors.
DOI of Published Version
10.3324/haematol.2016.154013
Source
Haematologica. 2017 Jan;102(1):e17-e21. doi: 10.3324/haematol.2016.154013. Epub 2016 Oct 6. Link to article on publisher's site
Journal/Book/Conference Title
Haematologica
Related Resources
PubMed ID
27758824
Repository Citation
Lian, Haiwei; Li, Dun; Zhou, Yun; Landesman-Bollag, Esther; Zhang, Guanglan; Anderson, Nicole M.; Tang, Kevin Charles; Roderick, Justine E.; Kelliher, Michelle A.; Seldin, David C.; Fu, Hui; and Feng, Hui, "CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells" (2017). UMass Metabolic Network Publications. 3.
https://escholarship.umassmed.edu/metnet_pubs/3
Included in
Biochemistry Commons, Cancer Biology Commons, Cell Biology Commons, Cellular and Molecular Physiology Commons, Molecular Biology Commons
Comments
Kevin Charles Tang participated in this study as a medical student as part of the Senior Scholars research program at the University of Massachusetts Medical School.