Title

Reversing behavioural abnormalities in mice exposed to maternal inflammation

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology; Program in Innate Immunity; UMass Metabolic Network

Publication Date

2017-09-28

Document Type

Article

Disciplines

Biochemistry | Cell Biology | Cellular and Molecular Physiology | Immunology and Infectious Disease | Molecular Biology

Abstract

Viral infection during pregnancy is correlated with increased frequency of neurodevelopmental disorders, and this is studied in mice prenatally subjected to maternal immune activation (MIA). We previously showed that maternal T helper 17 cells promote the development of cortical and behavioural abnormalities in MIA-affected offspring. Here we show that cortical abnormalities are preferentially localized to a region encompassing the dysgranular zone of the primary somatosensory cortex (S1DZ). Moreover, activation of pyramidal neurons in this cortical region was sufficient to induce MIA-associated behavioural phenotypes in wild-type animals, whereas reduction in neural activity rescued the behavioural abnormalities in MIA-affected offspring. Sociability and repetitive behavioural phenotypes could be selectively modulated according to the efferent targets of S1DZ. Our work identifies a cortical region primarily, if not exclusively, centred on the S1DZ as the major node of a neural network that mediates behavioural abnormalities observed in offspring exposed to maternal inflammation.

DOI of Published Version

10.1038/nature23909

Source

Nature. 2017 Sep 28;549(7673):482-487. doi: 10.1038/nature23909. Epub 2017 Sep 13. Link to article on publisher's site

Journal/Book/Conference Title

Nature

Comments

Full list of authors omitted for brevity. For full list see article.

Related Resources

Link to Article in PubMed

PubMed ID

28902835

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