Vms1 Relieves a Mitochondrial Import Chokehold
Department of Molecular, Cell, and Cancer Biology; UMass Metabolic Network
Biochemistry | Cell Biology | Cellular and Molecular Physiology | Developmental Biology | Molecular Biology
Ribosome stalling results in the production of truncated proteins that can cause proteotoxic stress if not efficiently degraded. A recent paper by Izawa et al. (2017) identifies Vms1 as a key player in the regulation of ribosome quality control specifically on mitochondria-localized ribosomes, ultimately preventing protein aggregate accumulation within mitochondria.
DOI of Published Version
Dev Cell. 2017 Nov 6;43(3):259-260. doi: 10.1016/j.devcel.2017.10.022. Link to article on publisher's site
Lamech L, Haynes CM. (2017). Vms1 Relieves a Mitochondrial Import Chokehold. UMass Metabolic Network Publications. https://doi.org/10.1016/j.devcel.2017.10.022. Retrieved from https://escholarship.umassmed.edu/metnet_pubs/148