Title

Vms1 Relieves a Mitochondrial Import Chokehold

UMMS Affiliation

Department of Molecular, Cell, and Cancer Biology; UMass Metabolic Network

Publication Date

2017-11-06

Document Type

Article

Disciplines

Biochemistry | Cell Biology | Cellular and Molecular Physiology | Developmental Biology | Molecular Biology

Abstract

Ribosome stalling results in the production of truncated proteins that can cause proteotoxic stress if not efficiently degraded. A recent paper by Izawa et al. (2017) identifies Vms1 as a key player in the regulation of ribosome quality control specifically on mitochondria-localized ribosomes, ultimately preventing protein aggregate accumulation within mitochondria.

DOI of Published Version

10.1016/j.devcel.2017.10.022

Source

Dev Cell. 2017 Nov 6;43(3):259-260. doi: 10.1016/j.devcel.2017.10.022. Link to article on publisher's site

Journal/Book/Conference Title

Developmental cell

Related Resources

Link to Article in PubMed

PubMed ID

29112848

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