Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer
Authors
Zaidi, Sayyed K.Frietze, Seth E.
Gordon, Jonathan A.
Heath, Jessica L.
Messier, Terri
Hong, Deli
Boyd, Joseph R.
Kang, Mingu
Imbalzano, Anthony N.
Lian, Jane B.
Stein, Janet L.
Stein, Gary S.
UMass Chan Affiliations
UMass Metabolic NetworkImbalzano Lab
Department of Biochemistry and Molecular Pharmacology
Graduate School of Biomedical Sciences, Program in Cell Biology
Document Type
Journal ArticlePublication Date
2017-11-13Keywords
bivalencycancer
epigenetic control
nuclear structure
oncofetal gene expression
Biochemistry
Cancer Biology
Cell Biology
Cellular and Molecular Physiology
Molecular Biology
Metadata
Show full item recordAbstract
Multiple mechanisms of epigenetic control that include DNA methylation, histone modification, noncoding RNAs, and mitotic gene bookmarking play pivotal roles in stringent gene regulation during lineage commitment and maintenance. Experimental evidence indicates that bivalent chromatin domains, i.e., genome regions that are marked by both H3K4me3 (activating) and H3K27me3 (repressive) histone modifications, are a key property of pluripotent stem cells. Bivalency of developmental genes during the G1 phase of the pluripotent stem cell cycle contributes to cell fate decisions. Recently, some cancer types have been shown to exhibit partial recapitulation of bivalent chromatin modifications that are lost along with pluripotency, suggesting a mechanism by which cancer cells reacquire properties that are characteristic of undifferentiated, multipotent cells. This bivalent epigenetic control of oncofetal gene expression in cancer cells may offer novel insights into the onset and progression of cancer and may provide specific and selective options for diagnosis as well as for therapeutic intervention.Source
Mol Cell Biol. 2017 Nov 13;37(23). pii: e00352-17. doi: 10.1128/MCB.00352-17. Print 2017 Dec 1. Link to article on publisher's siteDOI
10.1128/MCB.00352-17Permanent Link to this Item
http://hdl.handle.net/20.500.14038/36625PubMed ID
28923849Related Resources
Link to Article in PubMedRights
Copyright © 2017 American Society for Microbiology. Publisher PDF posted as allowed by the publisher's author rights policy at http://journals.asm.org/site/misc/ASM_Author_Statement.xhtml.ae974a485f413a2113503eed53cd6c53
10.1128/MCB.00352-17