UMMS Affiliation

Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network

Publication Date

2017-08-18

Document Type

Article

Disciplines

Biochemistry | Cell Biology | Cellular and Molecular Physiology | Molecular Biology

Abstract

Mitochondria are multifaceted and indispensable organelles required for cell performance. Accordingly, dysfunction to mitochondria can result in cellular decline and possibly the onset of disease. Cells use a variety of means to recover mitochondria and restore homeostasis, including the activation of retrograde pathways such as the mitochondrial unfolded protein response (UPRmt). In this Minireview, we will discuss how cells adapt to mitochondrial stress through UPRmt regulation. Furthermore, we will explore the current repertoire of biological functions that are associated with this essential stress-response pathway.

Keywords

Mitochondrial dysfunction, cell metabolism, cell signaling, cellular regulation, mitochondria, mitochondrial quality control, mitochondrial stress signaling, mitochondrial unfolded protein response, stress response

Rights and Permissions

© 2017 by The American Society for Biochemistry and Molecular Biology, Inc. Publisher PDF posted after 12 months as allowed by the publisher's author rights policy at http://www.jbc.org/site/misc/Copyright_Permission.xhtml.

DOI of Published Version

10.1074/jbc.R117.791061

Source

J Biol Chem. 2017 Aug 18;292(33):13500-13506. doi: 10.1074/jbc.R117.791061. Epub 2017 Jul 7. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of biological chemistry

Related Resources

Link to Article in PubMed

PubMed ID

28687630

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