Title
Vitiligo: Mechanistic Insights Lead to Novel Treatments
UMMS Affiliation
Department of Dermatology; Graduate School of Biomedical Sciences, Immunology and Microbiology Program; Graduate School of Biomedical Sciences, MD/PhD Program; UMass Metabolic Network
Publication Date
2017-08-01
Document Type
Article
Disciplines
Allergy and Immunology | Cellular and Molecular Physiology | Dermatology | Immune System Diseases | Skin and Connective Tissue Diseases
Abstract
Vitiligo is an autoimmune disease of the skin characterized by patchy depigmentation. Current treatments are moderately effective at reversing disease by suppressing autoimmune inflammation in the skin and promoting the regeneration of melanocytes. Recent basic and translational research studies have significantly improved our understanding of disease pathogenesis, which is now leading to emerging treatment strategies based on targeted therapy. Here we discuss important clinical characteristics of vitiligo, current therapies, their limitations, advances in understanding disease pathogenesis, emerging targeted treatments, and strategies to optimize clinical trials to efficiently and effectively test these new treatments.
DOI of Published Version
10.1016/j.jaci.2017.07.011
Source
J Allergy Clin Immunol. 2017 Sep;140(3):654-662. doi: 10.1016/j.jaci.2017.07.011. Epub 2017 Aug 1. Link to article on publisher's site
Journal/Book/Conference Title
The Journal of allergy and clinical immunology
Related Resources
PubMed ID
28778794
Repository Citation
Frisoli, Michael L. and Harris, John E., "Vitiligo: Mechanistic Insights Lead to Novel Treatments" (2017). UMass Metabolic Network Publications. 117.
https://escholarship.umassmed.edu/metnet_pubs/117