Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice
Program in Molecular Medicine; Department of Medicine, Division of Endocrinology, Metabolism and Diabetes; UMass Metabolic Network
Biochemistry | Cell Biology | Cellular and Molecular Physiology | Molecular Biology | Molecular, Genetic, and Biochemical Nutrition
SCOPE: Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti-obesity effect of gingerenone A (GA) in diet-induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI).
METHODS AND RESULTS: Oil red O staining showed that GA had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components tested at a single concentration (40 muM). Consistent with in vitro data, GA attenuates DIO by reducing fat mass in mice. This was accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in vitro and in vivo. Additionally, GA suppressed ATI by inhibiting macrophage recruitment and downregulating pro-inflammatory cytokines.
CONCLUSION: These results suggest that GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation.
AMP-activated protein kinase, Adipocyte, Adipose tissue inflammation, Gingerenone A, Obesity
DOI of Published Version
Mol Nutr Food Res. 2017 May 28. doi: 10.1002/mnfr.201700139. Link to article on publisher's site
Molecular nutrition and food research
Suk, Sujin; Kwon, Gyoo Taik; Lee, Eunjung; Jang, Woo Jung; Yang, Hee; Kim, Jong Hun; Thimmegowda, N. R.; Chung, Min-Yu; Kwon, Jung Yeon; Yang, Seunghee; Kim, Jason K.; Park, Jung Han Yoon; and Lee, Ki Won, "Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice" (2017). UMass Metabolic Network Publications. 110.