Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice
Program in Molecular Medicine; Department of Medicine, Division of Endocrinology, Metabolism and Diabetes; UMass Metabolic Network
Biochemistry | Cell Biology | Cellular and Molecular Physiology | Molecular Biology | Molecular, Genetic, and Biochemical Nutrition
SCOPE: Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti-obesity effect of gingerenone A (GA) in diet-induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI).
METHODS AND RESULTS: Oil red O staining showed that GA had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components tested at a single concentration (40 muM). Consistent with in vitro data, GA attenuates DIO by reducing fat mass in mice. This was accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in vitro and in vivo. Additionally, GA suppressed ATI by inhibiting macrophage recruitment and downregulating pro-inflammatory cytokines.
CONCLUSION: These results suggest that GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation.
AMP-activated protein kinase, Adipocyte, Adipose tissue inflammation, Gingerenone A, Obesity
DOI of Published Version
Mol Nutr Food Res. 2017 May 28. doi: 10.1002/mnfr.201700139. Link to article on publisher's site
Molecular nutrition and food research
Suk S, Kwon GT, Lee E, Jang WJ, Yang H, Kim JH, Thimmegowda NR, Chung M, Kwon JY, Yang S, Kim JK, Park JH, Lee KW. (2017). Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice. UMass Metabolic Network Publications. https://doi.org/10.1002/mnfr.201700139. Retrieved from https://escholarship.umassmed.edu/metnet_pubs/110