Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice
Authors
Suk, SujinKwon, Gyoo Taik
Lee, Eunjung
Jang, Woo Jung
Yang, Hee
Kim, Jong Hun
Thimmegowda, N. R.
Chung, Min-Yu
Kwon, Jung Yeon
Yang, Seunghee
Kim, Jason K.
Park, Jung Han Yoon
Lee, Ki Won
UMass Chan Affiliations
UMass Metabolic NetworkDepartment of Medicine, Division of Endocrinology, Metabolism and Diabetes
Program in Molecular Medicine
Document Type
Journal ArticlePublication Date
2017-05-28Keywords
AMP-activated protein kinaseAdipocyte
Adipose tissue inflammation
Gingerenone A
Obesity
Biochemistry
Cell Biology
Cellular and Molecular Physiology
Molecular Biology
Molecular, Genetic, and Biochemical Nutrition
Metadata
Show full item recordAbstract
SCOPE: Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti-obesity effect of gingerenone A (GA) in diet-induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI). METHODS AND RESULTS: Oil red O staining showed that GA had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components tested at a single concentration (40 muM). Consistent with in vitro data, GA attenuates DIO by reducing fat mass in mice. This was accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in vitro and in vivo. Additionally, GA suppressed ATI by inhibiting macrophage recruitment and downregulating pro-inflammatory cytokines. CONCLUSION: These results suggest that GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation.Source
Mol Nutr Food Res. 2017 May 28. doi: 10.1002/mnfr.201700139. Link to article on publisher's siteDOI
10.1002/mnfr.201700139Permanent Link to this Item
http://hdl.handle.net/20.500.14038/36590PubMed ID
28556482Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/mnfr.201700139