The Department of Molecular, Cell and Cancer Biology (MCCB) at the University of Massachusetts Medical School was established in 2015, and is the product of a merger between the Program in Gene Function and Expression and the Department of Cancer Biology. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Molecular, Cell and Cancer Biology. See earlier collections for selected Gene Function and Expression and Cancer Biology publications published before the departmental merger.

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Publications from 2021

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Akt Is S-Palmitoylated: A New Layer of Regulation for Akt, Matias Blaustein, Estefania Piegari, Camila Martinez Calejman, Antonella Vila, Analia Amante, Maria Victoria. Manese, Ari Zeida, Laurence Abrami, Mariela Veggetti, David A. Guertin, F. Gisou van der Goot, Maria Martha Corvi, and Alejandro Colman-Lerner

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Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma, Phoebe Carter, Ulrike Schnell, Christopher Chaney, Betty Tong, Xinchao Pan, Jianhua Ye, Glenda Mernaugh, Jennifer L. Cotton, Vitaly Margulis, Junhao Mao, Roy Zent, Bret M. Evers, Payal Kapur, and Thomas J. Carroll

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Protocol for the separation of extracellular vesicles by ultracentrifugation from in vitro cell culture models, Peter Chhoy, Caitlin W. Brown, John J. Amante, and Arthur M. Mercurio

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Dissection of Zebrafish Adult Melanocyte Stem Cell Signaling During Regeneration, William Tyler Frantz

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Consequences of aneuploidy in human fibroblasts with trisomy 21, Sunyoung Hwang, Paola Cavaliere, Rui Li, Lihua (Julie) Zhu, Noah Dephoure, and Eduardo M. Torres

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Bacterial processing of glucose modulates C. elegans lifespan and healthspan, Samuel F. Kingsley, Yonghak Seo, Calista Allen, Krishna S. Ghanta, Steven Finkel, and Heidi A. Tissenbaum

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xCT-Driven Expression of GPX4 Determines Sensitivity of Breast Cancer Cells to Ferroptosis Inducers, Namgyu Lee, Anne E. Carlisle, Austin Peppers, Sung Jin Park, Mihir B. Doshi, Meghan E. Spears, and Dohoon Kim

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Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling, Wei Ting C. Lee, Yandong Yin, Michael J. Morten, Peter Tonzi, Pam Pam Gwo, Diana C. Odermatt, Mauro Modesti, Sharon B. Cantor, Kerstin Gari, Tony T. Huang, and Eli Rothenberg

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Non-apoptotic enteroblast-specific role of the initiator caspase Dronc for development and homeostasis of the Drosophila intestine, Jillian L. Lindblad, Meghana Tare, Alla Amcheslavsky, Alicia Shields, and Andreas Bergmann

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Allele-specific knockdown of mutant HTT protein via editing at coding region SNP heterozygosities, Sarah Oikemus, Edith L. Pfister, Ellen Sapp, Kathryn O. Chase, Lori A. Kennington, Edward Hudgens, Rachael Miller, Lihua Julie Zhu, Akanksh Chaudhary, Eric O. Mick, Miguel Sena-Esteves, Scot A. Wolfe, Marian DiFiglia, Neil Aronin, and Michael H. Brodsky

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The ssDNA Theory of BRCAness and Genotoxic Agents, Nicholas J. Panzarino

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Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice, Pengpeng Liu, Shun-Qing Liang, Chunwei Zheng, Esther Mintzer, Yan G. Zhao, Karthikeyan Ponnienselvan, Aamir Mir, Erik J. Sontheimer, Guangping Gao, Terence R. Flotte, Scot A. Wolfe, and Wen Xue

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HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation, Hye Guk Ryu, Youngseob Jung, Namgyu Lee, Ji-Young Seo, Sung Wook Kim, Kyung-Ha Lee, Do-Yeon Kim, and Kyong-Tai Kim

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The NIH Somatic Cell Genome Editing program, Krishanu Saha, Erik J. Sontheimer, Guangping Gao, Anastasia Khvorova, Jonathan K. Watts, and Scot A. Wolfe

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UPR(mt) scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans, Tomer Shpilka, Yunguang Du, Qiyuan Yang, Andrew Melber, Nandhitha Uma Naresh, Joshua Lavelle, Sookyung Kim, Pengpeng Liu, Hilla Weidberg, Rui Li, Jun Yu, Lihua Julie Zhu, Lara Strittmatter, and Cole M. Haynes

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Cell-type specific circadian bioluminescence rhythms recorded from Dbp reporter mice reveal circadian oscillator misalignment [preprint], Ciearra B. Smith, Vincent van der Vinne, Eleanor McCartney, Adam C. Stowie, Tanya L. Leise, Blanca Martin-Burgos, Penny C. C. Molyneux, Lauren A. Garbutt, Michael H. Brodsky, Alec J. Davidson, Mary E. Harrington, Robert Dallmann, and David R. Weaver

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SARS-CoV-2 Reinfection in a Liver Transplant Recipient, Christopher H. Tomkins-Tinch, Jennifer S. Daly, Nicole M. Theodoropoulos, Michael P. Madaio, Neng Yu, Vijay K. Vanguri, Babak Movahedi, Adel Bozorgzadeh, Karl J. Simin, Jeremy Luban, Bronwyn L. MacInnis, Pardis C. Sabeti, and Stuart M. Levitz

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Histological assessment of developmental cell death in Drosophila pupae, Panagiotis D. Velentzas and Eric H. Baehrecke

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Leveraging the Cancer Stem Cell Glycome to Identify Aggressive Tumor Populations in Breast Cancer, Melanie R. Walker

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Deficient spermiogenesis in mice lacking Rlim, Feng Wang, Maria Gracia Gervasi, Ana Boskovic, Fengyun Sun, Vera D. Rinaldi, Jun Yu, Mary C. Wallingford, Darya A. Tourzani, Jesse Mager, Lihua Julie Zhu, Oliver J. Rando, Pablo E. Visconti, Lara Strittmatter, and Ingolf Bach

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Clarification of human blood ILC subtype interrelatedness and discovery of amphiregulin production by human NK cells shed light on HIV-1 pathogenesis [preprint], Yetao Wang, Lawrence M. Lifshitz, Noah J. Silverstein, Esther Mintzer, Kevin Luk, Pamela St. Louis, Michael A. Brehm, Scot A. Wolfe, Steven G. Deeks, and Jeremy Luban

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Characterization of R-Loop-Interacting Proteins in Embryonic Stem Cells, Tong Wu

Publications from 2020

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Transiently "Undead" Enterocytes Mediate Homeostatic Tissue Turnover in the Adult Drosophila Midgut, Alla Amcheslavsky, Jillian L. Lindblad, and Andreas Bergmann

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Tumor cell-organized fibronectin maintenance of a dormant breast cancer population, Lauren E. Barney, Christopher L. Hall, Alyssa D. Schwartz, Akia N. Parks, Christopher Sparages, Sualyneth Galarza, Manu O. Platt, Arthur M. Mercurio, and Shelly R. Peyton

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mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis, Camila Martinez Calejman, S. Trefely, S. W. Entwisle, Amelia K. Luciano, Su Myung. Jung, Wen-Yu Hsiao, A. Torres, C. M. Hung, H. Li, N. W. Snyder, J. Villen, K. E. Wellen, and David A. Guertin

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Exploring the Role of Selenocysteine Biosynthesis Enzyme SEPHS2 in Cancer, Anne E. Carlisle

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Unmasking Oncogene Addiction to the Epidermal Growth Factor Receptor in Triple Negative Breast Cancer: a Lesson in Intrinsic Resistance, Peter G. Cruz-Gordillo

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Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue, Neha Diwanji and Andreas Bergmann

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YAP1/TAZ drives ependymoma-like tumour formation in mice, Noreen Eder, Federico Roncaroli, Marie-Charlotte Dolmart, Stuart Horswell, Felipe Andreiuolo, Helen R. Flynn, Andre T. Lopes, Suzanne Claxton, John-Paul Kilday, Lucy Collinson, Junhao Mao, Torsten Pietsch, Barry Thompson, Ambrosius P. Snijders, and Sila K. Ultanir

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Innate Immunity in the C. elegans Intestine Is Programmed by a Neuronal Regulator of AWC Olfactory Neuron Development, Kyle J. Foster, Hilary K. Cheesman, Pengpeng Liu, Nicholas D. Peterson, Sarah M. Anderson, and Read Pukkila-Worley

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ESRRB regulates glucocorticoid gene expression in mice and patients with acute lymphoblastic leukemia, Kayleigh M. Gallagher, Justine E. Roderick, Shi Hao. Tan, Tze King Tan, Leonard Murphy, Jun Yu, Rui Li, Kevin O'Connor, Lihua Julie Zhu, Michael R. Green, Takaomi Sanda, and Michelle A. Kelliher

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The chromatin-binding domain of Ki-67 together with p53 protects human chromosomes from mitotic damage [preprint], Osama Garwain, Xiaoming Sun, Divya Ramalingam Iyer, Rui Li, Lihua Julie Zhu, and Paul D. Kaufman

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The Erythropoietin Receptor Stimulates Rapid Cycling and Formation of Larger Red Cells During Mouse and Human Erythropoiesis [preprint], Daniel Hidalgo, Jacob Bejder, Ramona Pop, Kyle Gellatly, S. Maxwell Scalf, Anna E. Eastman, Jane-Jane Chen, Lihua Julie Zhu, Jules A.A.C. Heuberger, Shangqin Guo, Mark J. Koury, Nikolai Baastrup Nordsborg, and Merav Socolovsky

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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development, Wen-Yu Hsiao, Su Myung Jung, Yuefeng Tang, John A. Haley, Rui Li, Huawei Li, Camila Martinez Calejman, Joan Sanchez-Gurmaches, Chien-Min Hung, Amelia K. Luciano, Victoria DeMambro, Kathryn E. Wellen, Clifford J. Rosen, Lihua Julie Zhu, and David A. Guertin

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NCAPG Dynamically Coordinates the Myogenesis of Fetal Bovine Tissue by Adjusting Chromatin Accessibility, Xin Hu, Yishen Xing, Xing Fu, Qiyuan Yang, Ling Ren, Yahui Wang, Qian Li, Junya Li, and Lupei Zhang

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bta-miR-23a Regulates the Myogenic Differentiation of Fetal Bovine Skeletal Muscle-Derived Progenitor Cells by Targeting MDFIC Gene, Xin Hu, Yishen Xing, Ling Ren, Yahui Wang, Qian Li, Qiyuan Yang, Min Du, Lingyang Xu, Luc Willems, Junya Li, and Lupei Zhang

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Precision Cas9 Genome Editing in vivo with All-in-one, Self-targeting AAV Vectors [preprint], Raed Ibraheim, Phillip W. L. Tai, Aamir Mir, Nida Javeed, Jiaming Wang, Tomas Rodriguez, Samantha J. Nelson, Eraj Khokhar, Esther Mintzer, Stacy Maitland​, Yueying Cao, Guangping Gao, and Erik J. Sontheimer

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Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope, Tingting Jiang, Xiao-Ou Zhang, Yueying Cao, Zhiping Weng, and Wen Xue

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The coordinate actions of calcineurin and Hog1 mediate the stress response through multiple nodes of the cell cycle network, Cassandra M. Leech, Mackenzie J. Flynn, Heather E. Arsenault, Jianhong Ou, Haibo Liu, Lihua Julie Zhu, and Jennifer A. Benanti

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Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes [preprint], Zongtao Lin, Xie Wang, Katelyn A. Bustin, Lin He, Radu M. Suciu, Nancy Schek, Mina Ahmadi, Kai Hu, Erika J. Olson, William H. Parsons, Eric S. Witze, Paul D. Morton, Ann M. Gregus, Matthew W. Buczynski, and Megan L. Matthews

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OneStopRNAseq: A Web Application for Comprehensive and Efficient Analyses of RNA-Seq Data, Rui Li, Kai Hu, Haibo Liu, Michael R. Green, and Lihua Julie Zhu

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Fucoxanthin attenuates LPS-induced acute lung injury via inhibition of the TLR4/MYD88 signaling axis, Xiaoling Li, Riming Huang, Kaifeng Liu, Mingyue Li, Hui Luo, Liao Cui, Lei Huang, and Lianxiang Luo

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Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis, Caterina Mancarella, Giulia Caldoni, Irene Ribolsi, Alessandro Parra, Maria Cristina Manara, Arthur M. Mercurio, Andrea Morrione, and Katia Scotlandi

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Beclin 1 Promotes Endosome Recruitment of Hepatocyte Growth Factor Tyrosine Kinase Substrate to Suppress Tumor Proliferation, Asia N. Matthew-Onabanjo, Jenny Janusis, Jose Mercado-Matos, Anne E. Carlisle, Dohoon Kim, Fayola Levine, Peter Cruz-Gordillo, Ryan Richards, Michael J. Lee, and Leslie M. Shaw (Cancer research, 2020-01-15)

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YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction, Masum M. Mia, Dasan Mary Cibi, Siti Aishah Abdul Ghani Binte, Weihua Song, Nicole Tee, Sujoy Ghosh, Junhao Mao, Eric N. Olson, and Manvendra K. Singh

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Translesion Synthesis Mediated Replication Gap Suppression, A Cancer Vulnerability, Sumeet Nayak

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Dynamics of the 4D genome during in vivo lineage specification and differentiation, A. Marieke Oudelaar, Daniel Hidalgo, Merav Socolovsky, Douglas R. Higgs, and Jim R. Hughes

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Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice [preprint], Pengpeng Liu, Shun-Qing Liang, Chunwei Zheng, Esther Mintzer, Yan G. Zhao, Karthikeyan Ponnienselvan, Aamir Mir, Erik J. Sontheimer, Guangping Gao, Terence R. Flotte, Scot A. Wolfe, and Wen Xue

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Drug antagonism and single-agent dominance result from differences in death kinetics, Ryan Richards, Hannah R. Schwartz, Megan E. Honeywell, Mariah S. Stewart, Peter Cruz-Gordillo, Anna J. Joyce, Benjamin D. Landry, and Michael J. Lee

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Evolved bacterial resistance against fluoropyrimidines can lower chemotherapy impact in the Caenorhabditis elegans host, Brittany Rosener, Serkan Sayin, Peter O. Oluoch, Aurian Garcia-Gonzalez, Hirotada Mori, Albertha J. M. Walhout, and Amir Mitchell

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Harnessing Cellular Senescence for Cancer Immunotherapy, Marcus Ruscetti

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UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import [preprint], Tomer Shpilka, Yunguang Du, Qiyuan Yang, Andrew Melber, Nandhitha Uma Naresh, Joshua Lavelle, Pengpeng Liu, Hilla Weidberg, Rui Li, Jun Yu, Lihua Julie Zhu, Lara Strittmatter, and Cole M. Haynes

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Genomic Characterization of Endothelial Enhancers Reveals a Multifunctional Role for NR2F2 in Regulation of Arteriovenous Gene Expression, Samir Sissaoui, Jun Yu, Aimin Yan, Rui Li, Onur Yukselen, Alper Kucukural, Lihua Julie Zhu, and Nathan D. Lawson

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YAP1 withdrawal in hepatoblastoma drives therapeutic differentiation of tumor cells to functional hepatocyte-like cells, Jordan L. Smith, Tomas Rodriguez, Haiwei Mou, Suet-Yan Kwan, Henry E. Pratt, Xiao-Ou Zhang, Yueying Cao, Shun-Qing Liang, Deniz M. Ozata, Tianxiong Yu, Qiangzong Yin, Max Hazeltine, Zhiping Weng, Erik J. Sontheimer, and Wen Xue

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Adenine base editing in an adult mouse model of tyrosinaemia, Chun-Qing Song, Tingting Jiang, Michelle Richter, Luke H. Rhym, Luke W. Koblan, Maria Paz Zafra, Emma M. Schatoff, Jordan L. Doman, Yueying Cao, Lukas E. Dow, Lihua Julie Zhu, Daniel G. Anderson, David R. Liu, Hao Yin, and Wen Xue

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ATF-4 and hydrogen sulfide signalling mediate longevity from inhibition of translation or mTORC1 [preprint], Cyril Statzer, Pengpeng Liu, Cole M. Haynes, T. Keith Blackwell, and Collin Y. Ewald

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Gender Identity and Sexual Orientation Identity in Women and Men Prenatally Exposed to Diethylstilbestrol, Rebecca Troisi, Julie R. Palmer, Elizabeth E. Hatch, William C. Strohsnitter, Dezheng Huo, Marianne Hyer, Karen I. Fredriksen-Goldsen, Robert Hoover, and Linda Titus

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Core binding factor leukemia hijacks T-cell prone PU.1 antisense promoter [preprint], E. van der Kouwe, Lucio H. Castilla, D. G. Tenen, and P. B. Staber

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ZNF410 represses fetal globin by devoted control of CHD4/NuRD [preprint], Divya S. Vinjamur, Qiuming Yao, Mitchel A. Cole, Connor McGuckin, Chunyan Ren, Jing Zeng, Mir Hossain, Kevin Luk, Scot A. Wolfe, Luca Pinello, and Daniel E. Bauer

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DGAT1 is a lipid metabolism oncoprotein that enables cancer cells to accumulate fatty acid while avoiding lipotoxicity [preprint], Daniel J. Wilcock, Melissa Kasheta, and Craig J. Ceol

Publications from 2019

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Benign ethnic neutropenia, Suheil Albert Atallah-Yunes, Audrey Ready, and Peter E. Newburger

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Tumor cell-organized fibronectin is required to maintain a dormant breast cancer population [preprint], Lauren E. Barney, Christopher L. Hall, Alyssa D. Schwartz, Akia N. Parks, Christopher Sparages, Sualyneth Galarza, Manu O. Platt, Arthur M. Mercurio, and Shelly R. Peyton

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BID-ding on necroptosis in MDS, Ben A. Croker and Michelle A. Kelliher

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Mitochondrial UPR repression during Pseudomonas aeruginosa infection requires the bZIP protein ZIP-3, Pan Deng, Nandhitha Uma Naresh, Yunguang Du, Lilian T. Lamech, Jun Yu, Lihua Julie Zhu, Read Pukkila-Worley, and Cole M. Haynes

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Two sides of the same coin – compensatory proliferation in regeneration and cancer, Neha Diwanji and Andreas Bergmann

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The Convergence of VEGF-Neuropilin and YAP/TAZ Signaling Promotes Stem-Like Traits and DNA Repair in Breast Cancer, Ameer L. Elaimy

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The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression, Ameer L. Elaimy, John J. Amante, Lihua Julie Zhu, Mengdie Wang, Charlotte Walmsley, Thomas J. Fitzgerald, Hira Lal Goel, and Arthur M. Mercurio

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Characterization and comparisons of microbiota in different intestinal segments between adult Chinese Shanxi Black Pigs and Large White Pigs, Pengfei Gao; Yulong Guo; Ningfang Zhang; Wanfeng Zhang; Hejie Wang; Xiaohong Guo; Zhibian Duan; Min Du; Qiyuan Yang; Bugao Li; Guangzhou Genedenovo Biotechnology Co., Ltd.; and Shanxi Agricultural University

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Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B, Xin Hu, Yishen Xing, Ling Ren, Yahui Wang, Qian Li, Xing Fu, Qiyuan Yang, Lingyang Xu, Luc Willems, Junya Li, and Lupei Zhang

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Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells, Sunyoung Hwang, Jessica F. Williams, Maja Kneissig, Maria Lioudyno, Isabel Rivera, Pablo Helguera, Jorge Busciglio, Zuzana Storchova, Megan C. King, and Eduardo M. Torres

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The Role of S-phase Speed During an Erythroid Transcriptional Switch, Yung Hwang

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Precise therapeutic gene correction by a simple nuclease-induced double-stranded break, Sukanya Iyer, Sneha Suresh, Dongsheng Guo, Katelyn Daman, Jennifer C. J. Chen, Pengpeng Liu, Marina Zieger, Kevin Luk, Benjamin P. Roscoe, Christian Mueller, Oliver D. King, Charles P. Emerson Jr., and Scot A. Wolfe

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Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity, Steven W. Jin, Nirmin Alsahafi, Xiaomei T. Kuang, Shayda A. Swann, Mako Toyoda, Heinrich G. Gottlinger, Bruce D. Walker, Takamasa Ueno, Andres Finzi, Zabrina L. Brumme, and Mark A. Brockman

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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1, Su Myung Jung, Chien-Min Hung, Samuel R. Hildebrand, Joan Sanchez-Gurmaches, Dimpi Mukhopadhyay, Camila Martinez Calejman, Amelia K. Luciano, Wen-Yu Hsiao, Yuefeng Tang, Huawei Li, and David A. Guertin

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Depletion of TRRAP induces p53-independent senescence in liver cancer by downregulating mitotic genes, Suet-Yan Kwan, Ankur Sheel, Chun-Qing Song, Xiao-Ou Zhang, Tingting Jiang, Hien Dang, Yueying Cao, Deniz M. Ozata, Haiwei Mou, Hao Yin, Zhiping Weng, Xin Wei Wang, and Wen Xue

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Tissue-restricted genome editing in vivo specified by microRNA-repressible anti-CRISPR proteins, Jooyoung Lee, Haiwei Mou, Raed Ibraheim, Shun-Qing Liang, Pengpeng Liu, Wen Xue, and Erik J. Sontheimer

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Which Should Be Used First for ALK-Positive Non-Small-Cell Lung Cancer: Chemotherapy or Targeted Therapy? A Meta-Analysis of Five Randomized Trials, Yen-Chien Lee, Chung-Cheng Hsieh, Yen-Ling Lee, and Chung-Yi Li

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Entosis Controls a Developmental Cell Clearance in C. elegans, Yongchan Lee, Jens C. Hamann, Mark Pellegrino, Joanne Durgan, Marie-Charlotte Domart, Lucy M. Collinson, Cole M. Haynes, Oliver Florey, and Michael Overholtzer

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The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation, Dongfang Li, Yan G. Zhao, Di Li, Hongyu Zhao, Jie Huang, Guangyan Miao, Du Feng, Pingsheng Liu, Dong Li, and Hong Zhang

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YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression, Huapeng Li, Qi Li, Kyvan Dang, Shan Ma, Jennifer L. Cotton, Sun Yang, Lihua Julie Zhu, April C. Deng, Y. Tony Ip, Randy L. Johnson, Xu Wu, Claudio Punzo, and Junhao Mao

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The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium, Qi Li, Niraj K. Nirala, Hsi-Ju Chen, Yingchao Nie, Wei Wang, Biliang Zhang, Michael P. Czech, Qi Wang, Lan Xu, Junhao Mao, and Y. Tony Ip

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Prosurvival kinase PIM2 is a therapeutic target for eradication of chronic myeloid leukemia stem cells, Leyuan Ma, Magnolia L. Pak, Jianhong Ou, Jun Yu, Pamela St Louis, Yi Shan, Lloyd Hutchinson, Shaoguang Li, Michael A. Brehm, Lihua Julie Zhu, and Michael R. Green

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An order-to-disorder structural switch activates the FoxM1 transcription factor, Aimee H. Marceau, Caileen M. Brison, Santrupti Nerli, Heather E. Arsenault, Andrew C. McShan, Eefei Chen, Hsiau-Wei Lee, Jennifer A. Benanti, Nikolaos G. Sgourakis, and Seth M. Rubin

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Novel Insight into the Autophagy-Independent Functions of Beclin 1 in Tumor Growth, Asia N. Matthew-Onabanjo

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Viral Infection or IFN-alpha Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels, William M. McDougall, Jill Perreira, Hui-Fang Hung, Anastassiia Vertii, E. Xiaofei, Wendy Zimmerman, Timothy F. Kowalik, Stephen J. Doxsey, and Abraham L. Brass

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VEGF/Neuropilin Signaling in Cancer Stem Cells, Arthur M. Mercurio

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Genome editing of HBG1 and HBG2 to induce fetal hemoglobin, Jean-Yves Metais, Kevin Luk, Scot A. Wolfe, Shengdar Q. Tsai, and Mitchell J. Weiss

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A critical role of VMP1 in lipoprotein secretion, Hideaki Morishita, Yan G. Zhao, Norito Tamura, Taki Nishimura, Yuki Kanda, Yuriko Sakamaki, Mitsuyo Okazaki, Dongfang Li, and Noboru Mizushima

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CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling, Haiwei Mou, Deniz M. Ozata, Jordan L. Smith, Ankur Sheel, Suet-Yan Kwan, Soren Hough, Alper Kucukural, Zachary Kennedy, Yueying Cao, and Wen Xue

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Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection, James D. Nhan, Christian D. Turner, Sarah M. Anderson, Chia-An Yen, Hans M. Dalton, Hilary K. Cheesman, Dana L. Ruter, Nandhitha Uma Naresh, Cole M. Haynes, Alexander A. Soukas, Read Pukkila-Worley, and Sean P. Curran

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Sptlc1 is essential for myeloid differentiation and hematopoietic homeostasis, Velayoudame Parthibane, Usha Acharya, and Jairaj K. Acharya

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F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear beta-catenin function, Debasish Paul, Sehbanul Islam, Rajesh Kumar. Manne, U. S. Dinesh, Sunil K. Malonia, Biswanath Maity, Ramanamurthy Boppana, Srikanth Rapole, Praveen Kumar Shetty, and Manas Kumar Santra

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Enhanced Cas12a editing in mammalian cells and zebrafish, Pengpeng Liu, Kevin Luk, Masahiro Shin, Feston Idrizi, Samantha F. Kwok, Benjamin P. Roscoe, Esther Mintzer, Sneha Suresh, Kyle Morrison, Josias B. Frazao, Mehmet Fatih Bolukbasi, Karthikeyan Ponnienselvan, Jeremy Luban, Lihua Julie Zhu, Nathan D. Lawson, and Scot A. Wolfe

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The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans, Nicholas D. Peterson, Hilary K. Cheesman, Pengpeng Liu, Sarah M. Anderson, Kyle J. Foster, Richa Chhaya, Paola N. Perrat, Jose Thekkiniath, Qiyuan Yang, Cole M. Haynes, and Read Pukkila-Worley

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Insulin Receptor Substrate-1 (IRS-1) and IRS-2 expression levels are associated with prognosis in non-small cell lung cancer (NSCLC), Andrew J. Piper, Jennifer L. Clark, Jose R. Mercado-Matos, Asia N. Matthew-Onabanjo, Chung-Cheng Hsieh, Ali Akalin, and Leslie M. Shaw

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Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia, Gayle P. Pouliot, Justine E. Roderick, and Alejandro Gutierrez

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Brown fat organogenesis and maintenance requires AKT1 and AKT2, Joan Sanchez-Gurmaches, Camila Martinez Calejman, Su Myung Jung, Huawei Li, and David A. Guertin

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MTF1, a classic metal sensing transcription factor, promotes myogenesis in response to copper [preprint], Cristina Tavera-Montañez, Sarah J. Hainer, Daniella Cangussu, Shellaina J. V. Gordon, Yao Xiao, Pablo Reyes-Gutierrez, Anthony N. Imbalzano, Juan G. Navea, Thomas G. Fazzio, and Teresita Padilla-Benavides

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Dietary alpha-ketoglutarate promotes beige adipogenesis and prevents obesity in middle-aged mice, Qiyu Tian, Junxing Zhao, Qiyuan Yang, Bo Wang, Jeanene M. Deavila, Mei-Jun Zhu, and Min Du

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alphavbeta3 Integrin Mediates Radioresistance of Prostate Cancer Cells Through Regulation of Survivin, Tao Wang, Jiayi Huang, Mai Vue, Michael R. Alavian, Hira Lal Goel, Dario C. Altieri, Lucia R. Languino, and Thomas J. Fitzgerald