The Department of Molecular, Cell and Cancer Biology (MCCB) at the University of Massachusetts Medical School was established in 2015, and is the product of a merger between the Program in Gene Function and Expression and the Department of Cancer Biology. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Molecular, Cell and Cancer Biology. See earlier collections for selected Gene Function and Expression and Cancer Biology publications published before the departmental merger.

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Publications from 2015

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Autophagy regulates tissue overgrowth in a context-dependent manner, Ernesto Perez, Guatam Das, Andreas Bergmann, and Eric H. Baehrecke

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Effect of preeclampsia on umbilical cord blood stem cells in relation to breast cancer susceptibility in the offspring, Li Qiu, Sagano Onoyama, Hoi Pang Low, Chien-I Chang, William C. Strohsnitter, Errol R. Norwitz, Mary Lopresti, Kathryn Edmiston, Mats Lambe, Dimitrios Trichopoulos, Pagona Lagiou, and Chung-Cheng Hsieh

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Subtle Controllers: MicroRNAs Drive Pancreatic Tumorigenesis and Progression: A Dissertation, Brian J. Quattrochi

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Autophagy-Independent Role for Beclin 1 in the Regulation of Growth Factor Receptor Signaling: A Dissertation, Rasika Rohatgi

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IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG, Sanjoy Samanta, Huayan Sun, Hira Lal Goel, Bryan M. Pursell, C. Chang, A. Khan, Dale L. Greiner, S. Cao, E. Lim, Leonard D. Shultz, and Arthur M. Mercurio

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Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages, MacLean Sellars, Jun R. Huh, Kenneth Day, Priya D. Issuree, Carolina Galan, Stephane Gobeil, Devin Absher, Michael R. Green, and Dan R. Littman

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Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia, Boris E. Shmukler, Nicholas C. Huston, Jonathan N. Thon, Chih-Wen Ni, George Kourkoulis, Nathan D. Lawson, Barry H. Paw, and Seth L. Alper

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Using C. elegans for aging research, Heidi A. Tissenbaum

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Transcriptional Regulation of the Drosophila Peptidoglycan Sensor PGRP-LC by the Steroid Hormone Ecdysone: A Masters Thesis, Mei Tong

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Yeast as Models of Mitotic Fidelity, Eduardo M. Torres

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Ral GTPase and the exocyst regulate autophagy in a tissue-specific manner, Kirsten Tracy, Panagiotis D. Velentzas, and Eric H. Baehrecke

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SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef, Yoshiko Usami, Yuanfei Wu, and Heinrich G. Gottlinger

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Highlights from the latest articles in nanomaterial-based therapies for targeting cancer stem cells, Tatsuyuki Yoshii, Yingying Geng, Ngoc DB Le, Hira Lal Goel, Arthur M. Mercurio, and Vincent M. Rotello

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Eaten alive: novel insights into autophagy from multicellular model systems, Hong Zhang and Eric H. Baehrecke

Publications from 2014

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Identification and Characteristics of Factors Regulating Hepatocellular Carcinoma Progression and Metastasis: A Dissertation, Leanne G. Ahronian

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TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein, Sanchita Bhatnagar, Claude Gazin, Lynn Chamberlain, Jianhong Ou, Xiaochun Zhu, Jogender S. Tushir, Ching-Man A. Virbasius, Ling Lin, Lihua Julie Zhu, Narendra Wajapeyee, and Michael R. Green

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Multiple mechanisms modulate distinct cellular susceptibilities toward apoptosis in the developing Drosophila eye, Yun Fan and Andreas Bergmann

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Detecting caspase activity in Drosophila larval imaginal discs, Caitlin E. Fogarty and Andreas Bergmann

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Investigating Tumor Suppressors in the DNA Damage Response: Caretakers of the Genome and Biomarkers to Predict Therapeutic Response: A Dissertation, Shawna S. Guillemette

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Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila, Q. Huang, Andreas Bergmann, X. Lin, and J. Qu

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Mechanistic Analysis of Differential Signal Transduction Mediated by the Insulin Receptor Substrate Proteins IRS-1 and IRS-2: A Dissertation, Justine M. Landis

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Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin beta4, Gengming Niu, Taiyang Ye, Liuliang Qin, Pierre M. Bourbon, Cheng Chang, Shengqiang Zhao, Yan Li, Lei Zhou, Pengfei Cui, Isaac Rabinovitz, Arthur M. Mercurio, Dezheng Zhao, and Huiyan Zeng

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GLI-IKBKE Requirement In KRAS-Induced Pancreatic Tumorigenesis: A Dissertation, Mihir S. Rajurkar

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Oncogene Function in Pre-Leukemia Stage of INV(16) Acute Myeloid Leukemia: A Dissertation, Liting Xue

Publications from 2013

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A Novel Autophagy Regulatory Mechanism that Functions During Programmed Cell Death: A Dissertation, Tsun-Kai Chang

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Expanding the Known DNA-binding Specificity of Homeodomains for Utility in Customizable Sequence-specific Nucleases: A Dissertation, Stephanie W. Chu

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UTX coordinates steroid hormone-mediated autophagy and cell death, Donna Denton, May T. Aung-Htut, Nirmal Lorensuhewa, Shannon Nicolson, Wenying Zhu, Kathryn Mills, Dimitrios Cakouros, Andreas Bergmann, and Sharad Kumar

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The Role and Regulation of Etv2 in Zebrafish Vascular Development: A Dissertation, John C. Moore

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Application of a Naïve Bayes Classifier to Assign Polyadenylation Sites from 3' End Deep Sequencing Data: A Dissertation, Sarah E. Sheppard

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The Notch1-c-Myc Pathway Mediates Leukemia-Initiating Cell Activity in Mouse T-ALL Models: A Dissertation, Jessica M. Tesell

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De-regulation of JNK and JAK/STAT signaling in ESCRT-II mutant tissues cooperatively contributes to neoplastic tumorigenesis, Sarah E. Woodfield, Hillary K. Graves, Jacob Hernandez, and Andreas Bergmann

Publications from 2012

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Mechanisms of KRAS-Mediated Pancreatic Tumor Formation and Progression: A Dissertation, Victoria A. Appleman

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Ligand-independent activation of the Hedgehog pathway displays non-cell autonomous proliferation during eye development in Drosophila, Audrey E. Christiansen, Tian Ding, and Andreas Bergmann

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Localization of Insulin Receptor Substrate-2 in Breast Cancer: A Dissertation, Jennifer L. Clark

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Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation, Hugh S. Gannon

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Analysis of Integrin α6β4 Function in Breast Carcinoma: A Dissertation, Kristin D. Gerson

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Notch signaling activates Yorkie non-cell autonomously in Drosophila, Hillary K. Graves, Sarah E. Woodfield, Chih-Chao Yang, Georg Halder, and Andreas Bergmann

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Getting a Tight Grip on DNA: Optimizing Zinc Fingers for Efficient ZFN-Mediated Gene Editing: A Dissertation, Ankit Gupta

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Genetic Approaches to Study Transcriptional Activation and Tumor Suppression: A Dissertation, Ling Lin

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Targeting the Histone Acetyl-Transferase, RTT109, for Novel Anti-Fungal Drug Development: A Dissertation, Jessica Lopes da Rosa-Spiegler

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Slow-Cycling Cancer Cells: A Dissertation, Nathan F. Moore

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Antagonistic Pleiotropy: The Role of Smurf2 in Cancer and Aging: A Dissertation, Charusheila Ramkumar

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The role of apoptosis-induced proliferation for regeneration and cancer, Hyung Don Ryoo and Andreas Bergmann

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Investigating the Roles of NEDD4.2s and Nef in the Release and Replication of HIV-1: A Dissertation, Eric R. Weiss

Publications from 2011

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Dynamics of Erythropoietic Survival Pathways In Vivo: A Dissertation, Miroslav Koulnis

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Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation, Tom V. Lee, Yun Fan, Shiuan Wang, Mayank Srivastava, Meike Broemer, Pascal Meier, and Andreas Bergmann

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Cooperating Events in Core Binding Factor Leukemia Development: A Dissertation, Dmitri Madera

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Insulin Receptor Substrate-2 (IRS-2): A Novel Hypoxia-Responsive Gene in Breast Cancer: A Dissertation, Katerina Mardilovich

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Digital and Analog STAT5 Signaling in Erythropoiesis: A Dissertation, Ermelinda Porpiglia

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Global DNA Demethylation During Erythropoiesis: A Dissertation, Jeffrey R. Shearstone

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Two Distinct Modes of Signaling by Vascular Endothelial Growth Factor C Guide Blood and Lymphatic Vessel Patterning in Zebrafish: A Dissertation, Jacques A. Villefranc

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Dissection of α6β4 Integrin-Dependent Signaling and Breast Carcinoma Invasion: A Dissertation, Xiaoqing Yang

Publications from 2010

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An Integral Role of ARRDC3 in Stem Cell Migration and Breast Cancer Progression: A Dissertation, Kyle M. Draheim

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Converging Pathways in the Regulation of Longevity and Metabolism in Caenorhabditis Elegans: A Dissertation, Sri Devi Narasimhan

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The Role of Rip2 Protein in the Nod Mediated Innate Immune Response: A Dissertation, Yibin Yang

Publications from 2009

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Mechanisms of NOTCH1 Mediated Leukemogenesis: A Dissertation, Kathleen J. Cullion

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Functional Analysis of MicroRNA-10b in Breast Carcinoma: A Dissertation, Charlotte M. Harwood Moriarty

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An Omega-Based Bacterial One-Hybrid System for the Determination of Transcription Factor Specificity, Marcus Blaine Noyes

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Worming to Complete the Insulin/IGF-1 Signaling Cascade: A Dissertation, Srivatsan Padmanabhan

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Regulation of BACH1/FANCJ Function in DNA Damage Repair: A Dissertation, Jenny X. Xie

Publications from 2008

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DNA Damage-Induced Apoptosis in the Presence and Absence of the Tumor Suppressor p53: A Dissertation, Laura Michelle McNamee

Publications from 2007

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A Genetic Analysis of Genomic Stability in Caenorhabditis Elegans: A Dissertation, Melissa M. Auclair

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Characterization of the BACH1 Helicase in the DNA Damage Response Pathway: a Dissertation, Rachel Litman

Publications from 2006

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Dissecting the Mechanism for the Selective Induction of Apoptosis in Transformed Cells by CAV Apoptin: a Dissertation, Destin W. Heilman

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Epigenetic Telomere Protection by Drosophila DNA Damage Response Pathways: A Dissertation, Sarah R. Oikemus

Publications from 2005

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The Identification of Cooperating Mutations in TAL1-Mediated Leukemia in the Mouse: A Dissertation, Jennifer Ann Calvo

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Regulation of Life Span by DAF-16/Forkhead Transcription Factor in Caenorhabditis elegans: A Dissertation, Seung Wook Oh

Publications from 2004

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Mechanisms of TAL1 Induced Leukemia in Mice: A Dissertation, Jennifer Elinor O'Neil

Publications from 1998

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Analysis of TAF II Function in the Yeast Saccharomyces Cerevisiae, Lynne Marie Apone