The Department of Molecular, Cell and Cancer Biology (MCCB) at the University of Massachusetts Medical School was established in 2015, and is the product of a merger between the Program in Gene Function and Expression and the Department of Cancer Biology. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Molecular, Cell and Cancer Biology. See earlier collections for selected Gene Function and Expression and Cancer Biology publications published before the departmental merger.

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Publications from 2016

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NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-kappaB-Dependent and -Independent Functions, Katerina Vlantis, Andy Wullaert, Apostolos Polykratis, Vangelis Kondylis, Marius Dannappel, Robin Schwarzer, Patrick Welz, Teresa Corona, Henning Walczak, Falk Weih, Ulf Klein, Michelle Kelliher, and Manolis Pasparakis

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Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila, Y. Wu, Jillian L. Lindblad, J. Garnett, H. E. Kamber Kaya, D. Xu, Y. Zhao, E. R. Flores, J. Hardy, and Andreas Bergmann

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Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo, Hao Yin, Chun-Qing Song, Joseph R. Dorkin, Lihua Julie Zhu, Yingxiang Li, Qiongqiong Wu, Angela I. Park, Junghoon Yang, Sneha Suresh, Aizhan Bizhanova, Ankit Gupta, Mehmet Fatih Bolukbasi, Stephen Walsh, Roman L. Bogorad, Guangping Gao, Zhiping Weng, Yizhou Dong, Victor Koteliansky, Scot A. Wolfe, Robert Langer, Wen Xue, and Daniel G. Anderson

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Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine, Tatsuyuki Yoshii, Yingying Geng, Shelly Peyton, Arthur M. Mercurio, and Vincent M. Rotello

Publications from 2015

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The p53R172H Mutant Does Not Enhance Hepatocellular Carcinoma Development and Progression, Leanne G. Ahronian, David R. Driscoll, David S. Klimstra, and Brian C. Lewis

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Autophagy in Cell Life and Cell Death, Allyson L. Anding and Eric H. Baehrecke

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Hcm1 integrates signals from Cdk1 and calcineurin to control cell proliferation, Heather E. Arsenault, Jagoree Roy, Claudine E. Mapa, Martha S. Cyert, and Jennifer A. Benanti

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Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants, Ankita Bansal, Lihua Julie Zhu, Kelvin Yen, and Heidi A. Tissenbaum

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Create, activate, destroy, repeat: Cdk1 controls proliferation by limiting transcription factor activity, Jennifer A. Benanti

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TRIMming down tumor suppressors in breast cancer, Sanchita Bhatnagar and Michael R. Green

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Integrating motif, DNA accessibility and gene expression data to build regulatory maps in an organism, Charles Blatti, Majid Kazemian, Scot A. Wolfe, Michael H. Brodsky, and Saurabh Sinha

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DNA-binding-domain fusions enhance the targeting range and precision of Cas9, Mehmet Fatih Bolukbasi, Ankit Gupta, Sarah Oikemus, Alan G. Derr, Manuel Garber, Michael H. Brodsky, Lihua Julie Zhu, and Scot A. Wolfe

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Runx1 is associated with breast cancer progression in MMTV-PyMT transgenic mice and its depletion in vitro inhibits migration and invasion, Gillian Browne, Hanna Taipaleenmaki, Nicole M. Bishop, Sharath C. Madasu, Leslie M. Shaw, Andre J. van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian

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Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo, Emerald Butko, Martin Distel, Claire Pouget, Bart Weijts, Isao Kobayashi, Kevin Ng, Christian Mosimann, Fabienne E. Poulain, Adam McPherson, Chih-Wen Ni, David L. Stachura, Natasha Del Cid, Raquel Espin-Palazon, Nathan D. Lawson, Richard Dorsky, Wilson K. Clements, and David Traver

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Function and Regulation of the α6 Integrins in Mammary Epithelial Biology and Breast Cancer: A Dissertation, Cheng Chang

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A laminin 511 matrix is regulated by TAZ and functions as the ligand for the alpha6Bbeta1 integrin to sustain breast cancer stem cells, Cheng Chang, Hira Lal Goel, Huijie Gao, Bryan M. Pursell, Leonard D. Shultz, Dale L. Greiner, Sulev Ingerpuu, Manuel Patarroyo, Shiliang Cao, Elgene Lim, Junhao Mao, Karen Kulju. McKee, Peter D. Yurchenco, and Arthur M. Mercurio

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Function and Regulation of the Tip60-p400 Complex in Embryonic Stem Cells: A Dissertation, Poshen B. Chen

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R loops regulate promoter-proximal chromatin architecture and cellular differentiation, Poshen B. Chen, Hsiuyi V. Chen, Diwash Acharya, Oliver J. Rando, and Thomas G. Fazzio

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Aldehyde Dehydrogenase Is Regulated by beta-Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells, Monica Cojoc, Claudia Peitzsch, Ina Kurth, Franziska Trautmann, Leoni A. Kunz-Schughart, Gennady D. Telegeev, Eduard A. Stakhovsky, John R. Walker, Karl Simin, Stephen Lyle, Susanne Fuessel, Kati Erdmann, Manfred P. Wirth, Mechthild Krause, Michael Baumann, and Anna Dubrovska

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Utilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis, Daniel M. Craig, Stephen P. Ashcroft, Micah Y. Belew, Ben Stocks, Kevin Currell, Keith Baar, and Andrew Philp

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Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice, Wissal El-Assaad, Karim El-Kouhen, Amro H. Mohammad, Jieyi Yang, Masahiro Morita, Isabelle Gamache, Orval Mamer, Daina Avizonis, Nicole M. Hermance, Sander Kersten, Michel L. Tremblay, Michelle A. Kelliher, and Jose G. Teodoro

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The CREB Coactivator CRTC2 Is a Lymphoma Tumor Suppressor that Preserves Genome Integrity through Transcription of DNA Mismatch Repair Genes, Minggang Fang, Magnolia L. Pak, Lynn Chamberlain, Wei Xing, Hongbo Yu, and Michael R. Green

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FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1), Sandra J. Feeney, Meagan J. McGrath, Absorn Sriratana, Stefan M. Gehrig, Gordon S. Lynch, Colleen E. D'Arcy, John T. Price, Catriona A. McLean, Rossella Ginevra Tupler, and Christina A. Mitchell

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The Sound of Silence: Signaling by Apoptotic Cells, Caitlin E. Fogarty and Andreas Bergmann

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Autophagy in malignant transformation and cancer progression, Lorenzo Galluzzi, Federico Pietrocola, Jose Manuel Bravo-San Pedro, Ravi K. Amaravadi, Eric H. Baehrecke, Francesco Cecconi, Patrice Codogno, Jayanta Debnath, David A. Gewirtz, Vassiliki Karantza, Alec Kimmelman, Sharad Kumar, Beth Levine, Maria Chiara Maiuri, Seamus J. Martin, Josef Penninger, Mauro Piacentini, David C. Rubinsztein, Hans-Uwe Simon, Anne Simonsen, Andrew M. Thorburn, Guillermo Velasco, Kevin M. Ryan, and Guido Kroemer

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Gene expression profiling for molecular staging of cutaneous melanoma in patients undergoing sentinel lymph node biopsy, Pedram Gerami, Robert W. Cook, Maria C. Russell, Jeff Wilkinson, Rodabe N. Amaria, Rene Gonzalez, Stephen Lyle, Gilchrist L. Jackson, Anthony J. Greisinger, Clare E. Johnson, Kristen M. Oelschlager, John F. Stone, Derek J. Maetzold, Laura K. Ferris, Jeffrey D. Wayne, Chelsea Cooper, Roxana Obregon, Keith A. Delman, and David Lawson

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Development of a prognostic genetic signature to predict the metastatic risk associated with cutaneous melanoma, Pedram Gerami, Robert W. Cook, Jeff Wilkinson, Maria C. Russell, Navneet Dhillon, Rodabe N. Amaria, Rene Gonzalez, Stephen Lyle, Clare E. Johnson, Kristen M. Oelschlager, Gilchrist L. Jackson, Anthony J. Greisinger, Derek Maetzold, Keith A. Delman, David H. Lawson, and John F. Stone

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Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4, Shawna S. Guillemette, Ryan W. Serra, Min Peng, Janelle A. Hayes, Panagiotis A. Konstantinopoulos, Michael R. Green, and Sharon B. Cantor

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Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF, Sarah J. Hainer, Weifeng Gu, Benjamin R. Carone, Benjamin D. Landry, Oliver J. Rando, Craig C. Mello, and Thomas G. Fazzio

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Venous-derived angioblasts generate organ-specific vessels during embryonic development, Gideon Hen, Julian Nicenboim, Oded Mayseless, Lihee Asaf, Masahiro Shin, Giorgia Busolin, Roy Hofi, Gabriella Almog, Natascia Tiso, Nathan D. Lawson, and Karina Yaniv

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Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity, Simone Hettmer, Michael M. Lin, Daria Tchessalova, Sara J. Tortorici, Alessandra Castiglioni, Tushar Desai, Junhao Mao, Andrew P. McMahon, and Amy J. Wagers

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Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFbeta-SMMHC delays leukemia in mice, Anuradha Illendula, John A. Pulikkan, Hongliang Zong, Jolanta Grembecka, Liting Xue, Siddhartha Sen, Yunpeng Zhou, Adam Boulton, Aravinda Kuntimaddi, Yan Gao, Roger A. Rajewski, Monica L. Guzman, Lucio H. Castilla, and John H. Bushweller

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Poised Regeneration of Zebrafish Melanocytes Involves Direct Differentiation and Concurrent Replenishment of Tissue-Resident Progenitor Cells, Sharanya Iyengar, Melissa Kasheta, and Craig J. Ceol

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Family history and risk of pregnancy-associated breast cancer (PABC), Anna L. Johansson V, Therese M-L. Andersson, Chung-Cheng Hsieh, Sven Cnattingius, Paul W. Dickman, and Mats Lambe

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IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions, Kohsuke Kanekura, Xiucui Ma, John T. Murphy, Lihua Julie Zhu, Abhinav Diwan, and Fumihiko Urano

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Research resource: Monitoring endoplasmic reticulum membrane integrity in beta-cells at the single-cell level, Kohsuke Kanekura, Jianhong Ou, Takashi Hara, Lihua (Julie) Zhu, and Fumihiko Urano

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Want reprogramming? Cut back on the chromatin assembly!, Paul D. Kaufman

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A platform for reverse genetics in endothelial cells, Fatma O. Kok and Nathan D. Lawson

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Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish, Fatma O. Kok, Masahiro Shin, Chih-Wen Ni, Ankit Gupta, Ann S. Grosse, Andreas van Impel, Bettina C. Kirchmaier, Josi Peterson-Maduro, George Kourkoulis, Ira Male, Dana F. DeSantis, Sarah Sheppard, Lwaki Ebarasi, Christer Betsholtz, Stefan Schulte-Merker, Scot A. Wolfe, and Nathan D. Lawson

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NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis, Vangelis Kondylis, Apostolos Polykratis, Hanno Ehlken, Laura Ochoa-Callejero, Beate Katharina Straub, Santosh Krishna-Subramanian, Trieu-My Van, Harald-Morten Curth, Nicole Heise, Falk Weih, Ulf Klein, Peter Schirmacher, Michelle A. Kelliher, and Manolis Pasparakis

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Integrin beta4 regulation of PTHrP underlies its contribution to mammary gland development, Jiarong Li, Huayan Sun, M. Laura Feltri, and Arthur M. Mercurio

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Current questions and possible controversies in autophagy, L M. Lindqvist, A K. Simon, and Eric H. Baehrecke

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Multicolor CRISPR labeling of chromosomal loci in human cells, Hanhui Ma, Ardalan Naseri, Pablo Reyes-Gutierrez, Scot A. Wolfe, Shaojie Zhang, and Thoru Pederson

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Prostate Tumorigenesis Induced by PTEN Deletion Involves Estrogen Receptor beta Repression, Paul Mak, Jianrong Li, Sanjoy Samanta, Cheng Chang, D. Joseph Jerry, Roger J. Davis, Irwin Leav, and Arthur M. Mercurio

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ERbeta regulation of NF-kB activation in prostate cancer is mediated by HIF-1, Paul Mak, Jiarong Li, Sanjoy Samanta, and Arthur M. Mercurio

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F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress, Sunil K. Malonia, Parul Dutta, Manas Kumar Santra, and Michael R. Green

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Grabbing the genome by the NADs, Timothy D. Matheson and Paul D. Kaufman

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Global Promotion of Alternative Internal Exon Usage by mRNA 3' End Formation Factors, Ashish Misra, Jianhong Ou, Lihua Julie Zhu, and Michael R. Green

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Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form, Matthew W. Parker, Andrew D. Linkugel, Hira Lal Goel, Tingting Wu, Arthur M. Mercurio, and Craig W. Vander Kooi

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Autophagy regulates tissue overgrowth in a context-dependent manner, Ernesto Perez, Guatam Das, Andreas Bergmann, and Eric H. Baehrecke

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Effect of preeclampsia on umbilical cord blood stem cells in relation to breast cancer susceptibility in the offspring, Li Qiu, Sagano Onoyama, Hoi Pang Low, Chien-I Chang, William C. Strohsnitter, Errol R. Norwitz, Mary Lopresti, Kathryn Edmiston, Mats Lambe, Dimitrios Trichopoulos, Pagona Lagiou, and Chung-Cheng Hsieh

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Subtle Controllers: MicroRNAs Drive Pancreatic Tumorigenesis and Progression: A Dissertation, Brian J. Quattrochi

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Autophagy-Independent Role for Beclin 1 in the Regulation of Growth Factor Receptor Signaling: A Dissertation, Rasika Rohatgi

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IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG, Sanjoy Samanta, Huayan Sun, Hira Lal Goel, Bryan M. Pursell, C. Chang, A. Khan, Dale L. Greiner, S. Cao, E. Lim, Leonard D. Shultz, and Arthur M. Mercurio

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Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages, MacLean Sellars, Jun R. Huh, Kenneth Day, Priya D. Issuree, Carolina Galan, Stephane Gobeil, Devin Absher, Michael R. Green, and Dan R. Littman

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Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia, Boris E. Shmukler, Nicholas C. Huston, Jonathan N. Thon, Chih-Wen Ni, George Kourkoulis, Nathan D. Lawson, Barry H. Paw, and Seth L. Alper

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Using C. elegans for aging research, Heidi A. Tissenbaum

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Transcriptional Regulation of the Drosophila Peptidoglycan Sensor PGRP-LC by the Steroid Hormone Ecdysone: A Masters Thesis, Mei Tong

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Yeast as Models of Mitotic Fidelity, Eduardo M. Torres

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Ral GTPase and the exocyst regulate autophagy in a tissue-specific manner, Kirsten Tracy, Panagiotis D. Velentzas, and Eric H. Baehrecke

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SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef, Yoshiko Usami, Yuanfei Wu, and Heinrich G. Gottlinger

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Highlights from the latest articles in nanomaterial-based therapies for targeting cancer stem cells, Tatsuyuki Yoshii, Yingying Geng, Ngoc DB Le, Hira Lal Goel, Arthur M. Mercurio, and Vincent M. Rotello

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Eaten alive: novel insights into autophagy from multicellular model systems, Hong Zhang and Eric H. Baehrecke

Publications from 2014

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Identification and Characteristics of Factors Regulating Hepatocellular Carcinoma Progression and Metastasis: A Dissertation, Leanne G. Ahronian

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TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein, Sanchita Bhatnagar, Claude Gazin, Lynn Chamberlain, Jianhong Ou, Xiaochun Zhu, Jogender S. Tushir, Ching-Man A. Virbasius, Ling Lin, Lihua Julie Zhu, Narendra Wajapeyee, and Michael R. Green

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Multiple mechanisms modulate distinct cellular susceptibilities toward apoptosis in the developing Drosophila eye, Yun Fan and Andreas Bergmann

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Detecting caspase activity in Drosophila larval imaginal discs, Caitlin E. Fogarty and Andreas Bergmann

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Investigating Tumor Suppressors in the DNA Damage Response: Caretakers of the Genome and Biomarkers to Predict Therapeutic Response: A Dissertation, Shawna S. Guillemette

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Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila, Q. Huang, Andreas Bergmann, X. Lin, and J. Qu

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Mechanistic Analysis of Differential Signal Transduction Mediated by the Insulin Receptor Substrate Proteins IRS-1 and IRS-2: A Dissertation, Justine M. Landis

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Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin beta4, Gengming Niu, Taiyang Ye, Liuliang Qin, Pierre M. Bourbon, Cheng Chang, Shengqiang Zhao, Yan Li, Lei Zhou, Pengfei Cui, Isaac Rabinovitz, Arthur M. Mercurio, Dezheng Zhao, and Huiyan Zeng

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GLI-IKBKE Requirement In KRAS-Induced Pancreatic Tumorigenesis: A Dissertation, Mihir S. Rajurkar

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Oncogene Function in Pre-Leukemia Stage of INV(16) Acute Myeloid Leukemia: A Dissertation, Liting Xue

Publications from 2013

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A Novel Autophagy Regulatory Mechanism that Functions During Programmed Cell Death: A Dissertation, Tsun-Kai Chang

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Expanding the Known DNA-binding Specificity of Homeodomains for Utility in Customizable Sequence-specific Nucleases: A Dissertation, Stephanie W. Chu

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UTX coordinates steroid hormone-mediated autophagy and cell death, Donna Denton, May T. Aung-Htut, Nirmal Lorensuhewa, Shannon Nicolson, Wenying Zhu, Kathryn Mills, Dimitrios Cakouros, Andreas Bergmann, and Sharad Kumar

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The Role and Regulation of Etv2 in Zebrafish Vascular Development: A Dissertation, John C. Moore

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Application of a Naïve Bayes Classifier to Assign Polyadenylation Sites from 3' End Deep Sequencing Data: A Dissertation, Sarah E. Sheppard

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The Notch1-c-Myc Pathway Mediates Leukemia-Initiating Cell Activity in Mouse T-ALL Models: A Dissertation, Jessica M. Tesell

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De-regulation of JNK and JAK/STAT signaling in ESCRT-II mutant tissues cooperatively contributes to neoplastic tumorigenesis, Sarah E. Woodfield, Hillary K. Graves, Jacob Hernandez, and Andreas Bergmann

Publications from 2012

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Mechanisms of KRAS-Mediated Pancreatic Tumor Formation and Progression: A Dissertation, Victoria A. Appleman

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Ligand-independent activation of the Hedgehog pathway displays non-cell autonomous proliferation during eye development in Drosophila, Audrey E. Christiansen, Tian Ding, and Andreas Bergmann

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Localization of Insulin Receptor Substrate-2 in Breast Cancer: A Dissertation, Jennifer L. Clark

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Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation, Hugh S. Gannon

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Analysis of Integrin α6β4 Function in Breast Carcinoma: A Dissertation, Kristin D. Gerson

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Notch signaling activates Yorkie non-cell autonomously in Drosophila, Hillary K. Graves, Sarah E. Woodfield, Chih-Chao Yang, Georg Halder, and Andreas Bergmann

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Getting a Tight Grip on DNA: Optimizing Zinc Fingers for Efficient ZFN-Mediated Gene Editing: A Dissertation, Ankit Gupta

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Genetic Approaches to Study Transcriptional Activation and Tumor Suppression: A Dissertation, Ling Lin

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Targeting the Histone Acetyl-Transferase, RTT109, for Novel Anti-Fungal Drug Development: A Dissertation, Jessica Lopes da Rosa-Spiegler

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Slow-Cycling Cancer Cells: A Dissertation, Nathan F. Moore

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Antagonistic Pleiotropy: The Role of Smurf2 in Cancer and Aging: A Dissertation, Charusheila Ramkumar

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The role of apoptosis-induced proliferation for regeneration and cancer, Hyung Don Ryoo and Andreas Bergmann

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Investigating the Roles of NEDD4.2s and Nef in the Release and Replication of HIV-1: A Dissertation, Eric R. Weiss

Publications from 2011

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Dynamics of Erythropoietic Survival Pathways In Vivo: A Dissertation, Miroslav Koulnis

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Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation, Tom V. Lee, Yun Fan, Shiuan Wang, Mayank Srivastava, Meike Broemer, Pascal Meier, and Andreas Bergmann

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Cooperating Events in Core Binding Factor Leukemia Development: A Dissertation, Dmitri Madera

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Insulin Receptor Substrate-2 (IRS-2): A Novel Hypoxia-Responsive Gene in Breast Cancer: A Dissertation, Katerina Mardilovich

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Digital and Analog STAT5 Signaling in Erythropoiesis: A Dissertation, Ermelinda Porpiglia

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Global DNA Demethylation During Erythropoiesis: A Dissertation, Jeffrey R. Shearstone

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Two Distinct Modes of Signaling by Vascular Endothelial Growth Factor C Guide Blood and Lymphatic Vessel Patterning in Zebrafish: A Dissertation, Jacques A. Villefranc