Title
The role of apoptosis-induced proliferation for regeneration and cancer
UMMS Affiliation
Department of Molecular, Cell and Cancer Biology
Publication Date
2012-08-01
Document Type
Article
Disciplines
Cancer Biology | Cell Biology | Genetics and Genomics | Molecular Biology
Abstract
Genes dedicated to killing cells must have evolved because of their positive effects on organismal survival. Positive functions of apoptotic genes have been well established in a large number of biological contexts, including their role in eliminating damaged and potentially cancerous cells. More recently, evidence has suggested that proapoptotic proteins-mostly caspases-can induce proliferation of neighboring surviving cells to replace dying cells. This process, that we will refer to as "apoptosis-induced proliferation," may be critical for stem cell activity and tissue regeneration. Depending on the caspases involved, at least two distinct types of apoptosis-induced proliferation can be distinguished. One of these types have been studied using a model in which cells have initiated cell death, but are prevented from executing it because of effector caspase inhibition, thereby generating "undead" cells that emit persistent mitogen signaling and overgrowth. Such conditions are likely to contribute to certain forms of cancer. In this review, we summarize the current knowledge of apoptosis-induced proliferation and discuss its relevance for tissue regeneration and cancer.
DOI of Published Version
10.1101/cshperspect.a008797
Source
Cold Spring Harb Perspect Biol. 2012 Aug 1;4(8):a008797. doi: 10.1101/cshperspect.a008797. Link to article on publisher's site
Journal/Book/Conference Title
Cold Spring Harbor perspectives in biology
Related Resources
PubMed ID
22855725
Repository Citation
Ryoo, Hyung Don and Bergmann, Andreas, "The role of apoptosis-induced proliferation for regeneration and cancer" (2012). Molecular, Cell and Cancer Biology Publications. 71.
https://escholarship.umassmed.edu/mccb_pubs/71