Department of Molecular, Cell and Cancer Biology
Cancer Biology | Cell Biology | Developmental Biology | Molecular Biology
BACKGROUND: ATG1 belongs to the Uncoordinated-51-like kinase protein family. Members of this family are best characterized for roles in macroautophagy and neuronal development. Apoptosis-induced proliferation (AiP) is a caspase-directed and JNK-dependent process which is involved in tissue repair and regeneration after massive stress-induced apoptotic cell loss. Under certain conditions, AiP can cause tissue overgrowth with implications for cancer.
RESULTS: Here, we show that Atg1 in Drosophila (dAtg1) has a previously unrecognized function for both regenerative and overgrowth-promoting AiP in eye and wing imaginal discs. dAtg1 acts genetically downstream of and is transcriptionally induced by JNK activity, and it is required for JNK-dependent production of mitogens such as Wingless for AiP. Interestingly, this function of dAtg1 in AiP is independent of its roles in autophagy and in neuronal development.
CONCLUSION: In addition to a role of dAtg1 in autophagy and neuronal development, we report a third function of dAtg1 for AiP.
Apoptosis-induced proliferation, Atg1, Autophagy, Jun-N-terminal kinase signaling, ULK1/2
DOI of Published Version
BMC Biol. 2016 Aug 19;14:70. doi: 10.1186/s12915-016-0293-y. Link to article on publisher's site
Li M, Lindblad JL, Perez E, Bergmann A, Fan Y. (2016). Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation. Molecular, Cell and Cancer Biology Publications. https://doi.org/10.1186/s12915-016-0293-y. Retrieved from https://escholarship.umassmed.edu/mccb_pubs/61
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