Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation
UMass Chan Affiliations
Department of Molecular, Cell and Cancer BiologyDocument Type
Journal ArticlePublication Date
2016-08-19Keywords
Apoptosis-induced proliferationAtg1
Autophagy
Jun-N-terminal kinase signaling
ULK1/2
Cancer Biology
Cell Biology
Developmental Biology
Molecular Biology
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BACKGROUND: ATG1 belongs to the Uncoordinated-51-like kinase protein family. Members of this family are best characterized for roles in macroautophagy and neuronal development. Apoptosis-induced proliferation (AiP) is a caspase-directed and JNK-dependent process which is involved in tissue repair and regeneration after massive stress-induced apoptotic cell loss. Under certain conditions, AiP can cause tissue overgrowth with implications for cancer. RESULTS: Here, we show that Atg1 in Drosophila (dAtg1) has a previously unrecognized function for both regenerative and overgrowth-promoting AiP in eye and wing imaginal discs. dAtg1 acts genetically downstream of and is transcriptionally induced by JNK activity, and it is required for JNK-dependent production of mitogens such as Wingless for AiP. Interestingly, this function of dAtg1 in AiP is independent of its roles in autophagy and in neuronal development. CONCLUSION: In addition to a role of dAtg1 in autophagy and neuronal development, we report a third function of dAtg1 for AiP.Source
BMC Biol. 2016 Aug 19;14:70. doi: 10.1186/s12915-016-0293-y. Link to article on publisher's siteDOI
10.1186/s12915-016-0293-yPermanent Link to this Item
http://hdl.handle.net/20.500.14038/36564PubMed ID
27542914Related Resources
Link to Article in PubMedDistribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.1186/s12915-016-0293-y
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/