Title

Yeast as Models of Mitotic Fidelity

UMMS Affiliation

Department of Molecular, Cell and Cancer Biology

Publication Date

9-17-2015

Document Type

Book Chapter

Disciplines

Cell Biology | Cellular and Molecular Physiology | Genetics | Genomics | Molecular Genetics | Pathological Conditions, Signs and Symptoms

Abstract

Chromosome missegregation leads to aneuploidy which is defined as the cellular state of having a chromosome count that is not an exact multiple of the haploid number. Aneuploidy is associated with human diseases including mental retardation, neurodegenerative diseases and cancer. In addition, aneuploidy is the major cause of spontaneous abortions and its occurrence increases with aging. Therefore, it is important to understand the molecular mechanisms by which cells respond and adapt to aneuploidy. Saccharomyces cerevisiae has proven to be a good model to study the effects aneuploidy elicits on cellular homeostasis and physiology. This chapter focuses on the current understanding of how the yeast S. cerevisiae responds to the acquisition of extra chromosomes and highlights how studies in aneuploid yeasts provide insights onto the effects of aneuploidy in human cells.

Keywords

Aneuploidy, Genomic instability, Proteotoxic stress, Reactive oxygen species

DOI of Published Version

10.1007/978-3-319-20291-4_7

Source

Recent Results Cancer Res. 2015;200:143-64. doi: 10.1007/978-3-319-20291-4_7. Link to article on publisher's site

Journal/Book/Conference Title

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer

Related Resources

Link to Article in PubMed

PubMed ID

26376876

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