Authors
Torres, Eduardo M.UMass Chan Affiliations
Department of Molecular, Cell and Cancer BiologyDocument Type
Book ChapterPublication Date
2015-09-17Keywords
AneuploidyGenomic instability
Proteotoxic stress
Reactive oxygen species
Cell Biology
Cellular and Molecular Physiology
Genetics
Genomics
Molecular Genetics
Pathological Conditions, Signs and Symptoms
Metadata
Show full item recordAbstract
Chromosome missegregation leads to aneuploidy which is defined as the cellular state of having a chromosome count that is not an exact multiple of the haploid number. Aneuploidy is associated with human diseases including mental retardation, neurodegenerative diseases and cancer. In addition, aneuploidy is the major cause of spontaneous abortions and its occurrence increases with aging. Therefore, it is important to understand the molecular mechanisms by which cells respond and adapt to aneuploidy. Saccharomyces cerevisiae has proven to be a good model to study the effects aneuploidy elicits on cellular homeostasis and physiology. This chapter focuses on the current understanding of how the yeast S. cerevisiae responds to the acquisition of extra chromosomes and highlights how studies in aneuploid yeasts provide insights onto the effects of aneuploidy in human cells.Source
Recent Results Cancer Res. 2015;200:143-64. doi: 10.1007/978-3-319-20291-4_7. Link to article on publisher's siteDOI
10.1007/978-3-319-20291-4_7Permanent Link to this Item
http://hdl.handle.net/20.500.14038/36551PubMed ID
26376876Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1007/978-3-319-20291-4_7