Title
Want reprogramming? Cut back on the chromatin assembly!
UMMS Affiliation
Department of Molecular, Cell and Cancer Biology
Publication Date
9-1-2015
Document Type
Article
Disciplines
Biochemistry | Cell Biology | Developmental Biology | Molecular Biology | Structural Biology
Abstract
Totipotency, the ability of early embryonic cells to generate a complete adult organism as well as extraembryonic tissue, is a fleeting property found only in very early embryonic cells. A breakthrough study now shows that inhibition of DNA replication–linked nucleosome assembly causes embryonic stem cells to resemble totipotent cells. Notably, inhibition of chromatin assembly stimulates reprogramming during somatic-cell nuclear transfer experiments.
DOI of Published Version
10.1038/nsmb.3081
Source
Nat Struct Mol Biol. 2015 Sep;22(9):648-50. doi: 10.1038/nsmb.3081. Link to article on publisher's site
Journal/Book/Conference Title
Nature structural and molecular biology
Related Resources
PubMed ID
26333710
Repository Citation
Kaufman, Paul D., "Want reprogramming? Cut back on the chromatin assembly!" (2015). Molecular, Cell and Cancer Biology Publications. 46.
https://escholarship.umassmed.edu/mccb_pubs/46