Want reprogramming? Cut back on the chromatin assembly!
Department of Molecular, Cell and Cancer Biology
Biochemistry | Cell Biology | Developmental Biology | Molecular Biology | Structural Biology
Totipotency, the ability of early embryonic cells to generate a complete adult organism as well as extraembryonic tissue, is a fleeting property found only in very early embryonic cells. A breakthrough study now shows that inhibition of DNA replication–linked nucleosome assembly causes embryonic stem cells to resemble totipotent cells. Notably, inhibition of chromatin assembly stimulates reprogramming during somatic-cell nuclear transfer experiments.
DOI of Published Version
Nat Struct Mol Biol. 2015 Sep;22(9):648-50. doi: 10.1038/nsmb.3081. Link to article on publisher's site
Nature structural and molecular biology
Kaufman, Paul D., "Want reprogramming? Cut back on the chromatin assembly!" (2015). Molecular, Cell and Cancer Biology Publications. 46.