Title
Family history and risk of pregnancy-associated breast cancer (PABC)
UMMS Affiliation
Department of Molecular, Cell and Cancer Biology
Publication Date
2015-05-01
Document Type
Article
Disciplines
Clinical Epidemiology | Epidemiology | Female Urogenital Diseases and Pregnancy Complications | Maternal and Child Health | Neoplasms | Obstetrics and Gynecology | Oncology | Women's Health
Abstract
The risk of breast cancer is at least two-fold increased in young women with a family history of breast cancer. Pregnancy has a dual effect on breast cancer risk; a short-term increase followed by a long-term protection. We investigated if the risk of breast cancer during and within 10 years following pregnancy is affected by a family history of breast cancer. We followed a cohort of women aged 15-44 years between 1963 and 2009 identified in Swedish population-based registers. Family history was defined as having a mother or sister with breast cancer. We estimated incidence rate ratios of breast cancer during pregnancy and time intervals up to 10 years post-delivery, with a focus on pregnancy-associated breast cancer (PABC), defined as breast cancer during pregnancy or within 2 years post-delivery. In 3,452,506 women, there were 15,548 cases of breast cancer (1208 were PABC). Compared to nulliparous women, the risk of breast cancer was decreased during pregnancy, similar during first year and increased during second year post-delivery. The pattern was similar in women with or without family history of breast cancer. A peak in risk was observed 5-6 years following the first birth regardless of family history. After a second birth, this peak was only present in women with a family history. Our results indicate that women with a family history of breast cancer do not have a different breast cancer risk during and within 10 years following pregnancy compared to women without a family history.
DOI of Published Version
10.1007/s10549-015-3369-4
Source
Breast Cancer Res Treat. 2015 May;151(1):209-17. doi: 10.1007/s10549-015-3369-4. Epub 2015 Apr 19.Link to article on publisher's site
Journal/Book/Conference Title
Breast cancer research and treatment
Related Resources
PubMed ID
25893584
Repository Citation
Johansson, Anna L. V; Andersson, Therese M-L.; Hsieh, Chung-Cheng; Cnattingius, Sven; Dickman, Paul W.; and Lambe, Mats, "Family history and risk of pregnancy-associated breast cancer (PABC)" (2015). Molecular, Cell and Cancer Biology Publications. 38.
https://escholarship.umassmed.edu/mccb_pubs/38