Title

Autophagy in Cell Life and Cell Death

UMMS Affiliation

Department of Molecular, Cell, and Cancer Biology

Publication Date

2015-09-09

Document Type

Book Chapter

Disciplines

Cell Biology | Cellular and Molecular Physiology | Developmental Biology

Abstract

Macroautophagy (hereafter referred to as autophagy) is a process used by the cell to deliver cytoplasmic components to the lysosome for degradation. Autophagy is most often associated with cell survival, as it provides cells with molecular building blocks during periods of nutrient deprivation and also aids in the elimination of damaged organelles and protein aggregates. However, autophagy has also been implicated in cell death. Here, we review what is known about autophagy, its regulation, its role both in cell life and cell death, and what is known about autophagic cell death in vivo.

Keywords

Apoptosis, Atg genes, Autophagy, Caspase, Necrosis, Programmed cell death

DOI of Published Version

10.1016/bs.ctdb.2015.07.012

Source

Curr Top Dev Biol. 2015;114:67-91. doi: 10.1016/bs.ctdb.2015.07.012. Epub 2015 Sep 9. Link to article on publisher's site

Journal/Book/Conference Title

Current topics in developmental biology

Related Resources

Link to Article in PubMed

PubMed ID

26431564

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