UMMS Affiliation

Department of Molecular, Cell and Cancer Biology; Program in Molecular Medicine

Publication Date


Document Type



Breast Neoplasms; Extracellular Matrix; Female; Humans; Integrin alpha6beta1; Laminin; Ligands; Neoplastic Stem Cells; Transcription Factors


Cancer Biology | Cell Biology | Cells | Developmental Biology | Molecular Biology


Understanding how the extracellular matrix impacts the function of cancer stem cells (CSCs) is a significant but poorly understood problem. We report that breast CSCs produce a laminin (LM) 511 matrix that promotes self-renewal and tumor initiation by engaging the alpha6Bbeta1 integrin and activating the Hippo transducer TAZ. Although TAZ is important for the function of breast CSCs, the mechanism is unknown. We observed that TAZ regulates the transcription of the alpha5 subunit of LM511 and the formation of a LM511 matrix. These data establish a positive feedback loop involving TAZ and LM511 that contributes to stemness in breast cancer.

Rights and Permissions

© 2015 Chang et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at

DOI of Published Version



Genes Dev. 2015 Jan 1;29(1):1-6. doi: 10.1101/gad.253682.114. Link to article on publisher's site

Journal/Book/Conference Title

Genes and development

Related Resources

Link to Article in PubMed

PubMed ID