Eaten alive: novel insights into autophagy from multicellular model systems
Department of Molecular, Cell and Cancer Biology
Cell Biology | Cells | Cellular and Molecular Physiology
Autophagy delivers cytoplasmic material to lysosomes for degradation. First identified in yeast, the core genes that control this process are conserved in higher organisms. Studies of mammalian cell cultures have expanded our understanding of the core autophagy pathway, but cannot reveal the unique animal-specific mechanisms for the regulation and function of autophagy. Multicellular organisms have different types of cells that possess distinct composition, morphology, and organization of intracellular organelles. In addition, the autophagic machinery integrates signals from other cells and environmental conditions to maintain cell, tissue and organism homeostasis. Here, we highlight how studies of autophagy in flies and worms have identified novel core autophagy genes and mechanisms, and provided insight into the context-specific regulation and function of autophagy.
DOI of Published Version
Trends Cell Biol. 2015 Apr 7. pii: S0962-8924(15)00047-1. doi: 10.1016/j.tcb.2015.03.001. Link to article on publisher's site
Trends in cell biology
Zhang H, Baehrecke EH. (2015). Eaten alive: novel insights into autophagy from multicellular model systems. Molecular, Cell and Cancer Biology Publications. https://doi.org/10.1016/j.tcb.2015.03.001. Retrieved from https://escholarship.umassmed.edu/mccb_pubs/2