The Department of Molecular, Cell and Cancer Biology (MCCB) at the University of Massachusetts Medical School was established in 2015, and is the product of a merger between the Program in Gene Function and Expression and the Department of Cancer Biology. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Molecular, Cell and Cancer Biology. See earlier collections for selected Gene Function and Expression and Cancer Biology publications published before the departmental merger.

Follow


Publications from 2018

PDF

NmeCas9 is an intrinsically high-fidelity genome editing platform, Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

PDF

Are membranes non-apoptotic compartments for apoptotic caspases, Andreas Bergmann

PDF

Cell clustering mediated by the adhesion protein PVRL4 is necessary for alpha6beta4 integrin-promoted ferroptosis resistance in matrix-detached cells, Caitlin W. Brown, John J. Amante, and Arthur M. Mercurio

PDF

Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis, Qingbo Chen, Lei Huang, Dongning Pan, Lihua (Julie) Zhu, and Yong-Xu Wang

PDF

RUNX1 Is an Oncogenic Transcription Factor that Regulates MYB and MYC Enhancer Activity in T-ALL, AHyun Choi

PDF

SERINC5: Its Sensitivity to Nef and Restriction of HIV-1, Weiwei Dai

PDF

A Long Cytoplasmic Loop Governs the Sensitivity of the Anti-viral Host Protein SERINC5 to HIV-1 Nef, Weiwei Dai, Yoshiko Usami, Yuanfei Wu, and Heinrich G. Gottlinger

Link

VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP beta2-chimaerin, Ameer L. Elaimy, Santosh Guru, Cheng Chang, Jianhong Ou, John J. Amante, Lihua Julie Zhu, Hira Lal Goel, and Arthur M. Mercurio

PDF

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018, Lorenzo Galluzzi, Eric H. Baehrecke, Francis Ka-Ming Chan, and Guido Kroemer

PDF

C-BERST: Defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2, Xin D. Gao, Li-Chun Tu, Aamir Mir, Tomas Rodriguez, Yue-He Ding, John D. Leszyk, Job Dekker, Scott A. Shaffer, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

Link

C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2, Xin D. Gao, Li-Chun Tu, Aamir Mir, Tomas Rodriguez, Yue-He Ding, John D. Leszyk, Job Dekker, Scott A. Shaffer, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer (Nature methods, 2018-05-07)

Link

Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays, Yingying Geng, Hira Lal Goel, Ngoc B. Le, Tatsuyuki Yoshii, Rubul Mout, Gulen Y. Tonga, John J. Amante, Arthur M. Mercurio, and Vincent M. Rotello

PDF

A large-scale RNA interference screen identifies genes that regulate autophagy at different stages, Sujuan Guo, Kevin J. Pridham, Ching-Man A. Virbasius, Bin He, Liqing Zhang, Hanne Varmark, Michael R. Green, and Zhi Sheng

PDF

Identification of Epigenetic Regulators of DUX4-fl for Targeted Therapy of Facioscapulohumeral Muscular Dystrophy, Charis L. Himeda, Takako I. Jones, Ching-Man A. Virbasius, Lihua Julie Zhu, Michael R. Green, and Peter L. Jones

Link

UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response, L. N. Huiting, Y. Samaha, G. L. Zhang, Justine E. Roderick, B. Li, N. M. Anderson, Y. W. Wang, L. Wang, F. Laroche, J. W. Choi, C. T. Liu, Michelle A. Kelliher, and H. Feng

PDF

Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells, Benjamin D. Landry, Thomas Leete, Ryan Richards, Peter Cruz-Gordillo, Hannah R. Schwartz, Megan E. Honeywell, Gary Ren, Alyssa D. Schwartz, Shelly R. Peyton, and Michael J. Lee (Molecular systems biology, 2018-08-06)

Link

Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth, Qi Li, Niraj K. Nirala, Yingchao Nie, Hsi-Ju Chen, Gary R. Ostroff, Junhao Mao, Qi Wang, Lan Xu, and Y. Tony Ip

PDF

Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2, Jose Mercado-Matos, Jenny Janusis, Sha Zhu, Samuel S. Chen, and Leslie M. Shaw

PDF

Heavily and Fully Modified RNAs Guide Efficient SpyCas9-Mediated Genome Editing, Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts, and Erik J. Sontheimer

PDF

Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing, Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts, and Erik J. Sontheimer

PDF

ATACseqQC: a Bioconductor package for post-alignment quality assessment of ATAC-seq data, Jianhong Ou, Haibo Liu, Jun Yu, Michelle A. Kelliher, Lucio H. Castilla, Nathan D. Lawson, and Lihua Julie Zhu

Link

Mitochondrial Biogenesis: MitoCPR Resuscitates Import-Defective Mitochondria, Jacqueline Pires and Cole M. Haynes

PDF

Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia, John A. Pulikkan and Lucio H. Castilla

Link

CBFbeta-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia, John A. Pulikkan, Mahesh Hegde, Hafiz Mohd Ahmad, Houda Belaghzal, Anuradha Illendula, Jun Yu, Kelsey O'Hagan, Jianhong Ou, Carsten Muller-Tidow, Scot A. Wolfe, Lihua J. Zhu, Job Dekker, John Hackett Bushweller, and Lucio H. Castilla (Cell, 2018-06-28)

PDF

IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer, Sanjoy Samanta, Santosh Guru, Ameer L. Elaimy, John J. Amante, Jianhong Ou, Jun Yu, Lihua Julie Zhu, and Arthur M. Mercurio

PDF

IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer, Sanjoy Samanta, Santosh Guru, Ameer L. Elaimy, John J. Amante, Jianhong Ou, Jun Yu, Lihua Julie Zhu, and Arthur M. Mercurio

PDF

Impact of Concurrent Genomic Alterations Detected by Comprehensive Genomic Sequencing on Clinical Outcomes in East-Asian Patients with EGFR-Mutated Lung Adenocarcinoma, Seijiro Sato, Stephen Lyle, Toshifumi Wakai, and Masanori Tsuchida

Link

Metabolic shift from glycogen to trehalose promotes lifespan and healthspan in Caenorhabditis elegans, Yonghak Seo, Samuel F. Kingsley, Griffin Walker, Michelle A. Mondoux, and Heidi A. Tissenbaum

Link

In vivo genome editing partially restores alpha1-antitrypsin in a murine model of AAT deficiency, Chun-Qing Song, Dan Wang, Tingting Jiang, Kevin O'Connor, Qiushi Tang, Lingling Cai, Xiangrui Li, Zhiping Weng, Hao Yin, Guangping Gao, Christian Mueller, Terence R. Flotte, and Wen Xue

PDF

Emergence of the erythroid lineage from multipotent hematopoiesis, Betsabeh K. Tusi, Samuel L. Wolock, Caleb Weinreb, Yung Hwang, Daniel Hidalgo, Rapolas Zilionis, Ari Waisman, Jun R. Huh, Allon M. Klein, and Merav Socolovsky

PDF

Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging, Chuangqi Wang, Hee June Choi, Sung-Jin Kim, Aesha Desai, Namgyu Lee, Dohoon Kim, Yongho Bae, and Kwonmoo Lee

PDF

Deconvolution Of Subcellular Protrusion Heterogeneity And The Underlying Actin Regulator Dynamics From Live Cell Imaging, Chuangqi Wang, Hee June Choi, Sung-Jin Kim, Aesha Desai, Namgyu Lee, Dohoon Kim, Yongho Bae, and Kwonmoo Lee

Link

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity, Hao Yin, Chun-Qing Song, Sneha Suresh, Suet-Yan Kwan, Qiongqiong Wu, Stephen Walsh, Junmei Ding, Roman L. Bogorad, Lihua Julie Zhu, Scot A. Wolfe, Victor Koteliansky, Wen Xue, Robert Langer, and Daniel G. Anderson

PDF

The Role of RIPK1 Kinase Activity in Regulating Inflammation and Necroptotic Death, Matija Zelic

PDF

RIP kinase 1-dependent endothelial necroptosis underlies systemic inflammatory response syndrome, Matija Zelic, Justine E. Roderick, Joanne A. O'Donnell, Jesse Lehman, Sung Eun Lim, Harish P. Janardhan, Chinmay M. Trivedi, Manolis Pasparakis, and Michelle A. Kelliher

PDF

The temporal landscape of recursive splicing during Pol II transcription elongation in human cells, Xiao-Ou Zhang, Yu Fu, Haiwei Mou, Wen Xue, and Zhiping Weng

PDF

IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma, Sha Zhu, B. Marie Ward, Jun Yu, Asia N. Matthew-Onabanjo, Jenny Janusis, Chung-Cheng Hsieh, Keith Tomaszewicz, Lloyd Hutchinson, Lihua Julie Zhu, Dina Kandil, and Leslie M. Shaw

Publications from 2017

PDF

Understanding Multiple Independent Functions of the Tip60 Acetyltransferase in Embryonic Development, Diwash Acharya

Link

Cleaning House: Selective Autophagy of Organelles, Allyson L. Anding and Eric H. Baehrecke

PDF

Development of Chimeric Cas9 Nucleases for Accurate and Flexible Genome Editing, Mehmet F. Bolukbasi

PDF

A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival, Elias Bou Samra, Geraldine Buhagiar-Labarchede, Christelle Machon, Jerome Guitton, Rosine Onclercq-Delic, Michael R. Green, Olivier Alibert, Claude Gazin, Xavier Veaute, and Mounira Amor-Gueret

PDF

The alpha6beta4 integrin promotes resistance to ferroptosis, Caitlin W. Brown, John J. Amante, Hira Lal Goel, and Arthur M. Mercurio

Link

Molecular Basis and Targeted Inhibition of CBFbeta-SMMHC Acute Myeloid Leukemia, Lucio H. Castilla and John H. Bushweller

Link

RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia, AHyun Choi, Anuradha Illendula, John A. Pulikkan, Justine E. Roderick, Jessica M. Tesell, Jun Yu, Nicole M. Hermance, Lihua (Julie) Zhu, Lucio H. Castilla, John H. Bushweller, and Michelle A. Kelliher

PDF

JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias, C. Delgado-Martin, L. K. Meyer, B. J. Huang, M. S. Zinter, J. V. Nguyen, G. A. Smith, J. Taunton, S. S. Winter, Justine R. Roderick, Michelle A. Kelliher, T. M. Horton, B. L. Wood, D. T. Teachey, and M. L. Hermiston

Link

Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR, Pan Deng and Cole M. Haynes

PDF

Regulation of Pluripotency and Differentiation by Chromatin Remodeling Factors, Ly-Sha Ee

PDF

Clinical application of a cancer genomic profiling assay to guide precision medicine decisions, Cheryl Eifert, Angeliki Pantazi, Ruobai Sun, Jia Xu, Pablo Cingolani, Joerg Heyer, Meaghan Russell, Maria Lvova, Jennifer Ring, Julie Y. Tse, Stephen Lyle, and Alexei Protopopov

Link

Integrating the UPRmt into the mitochondrial maintenance network, Christopher J. Fiorese and Cole M. Haynes

PDF

Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease, Caitlin E. Fogarty and Andreas Bergmann

Link

Molecular definitions of autophagy and related processes, Lorenzo Galluzzi, Eric H. Baehrecke, and Guido Kroemer

PDF

Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation, Lei Huang, Dongning Pan, Qingbo Chen, Lihua (Julie) Zhu, Jianhong Ou, Martin Wabitsch, and Yong-Xu Wang

PDF

Serine-Dependent Sphingolipid Synthesis Is a Metabolic Liability of Aneuploid Cells, Sunyoung Hwang, H. Tobias Gustafsson, Ciara O'Sullivan, Gianna Bisceglia, Xinhe Huang, Christian Klose, Andrej Schevchenko, Robert C. Dickson, Paola Cavaliere, Noah Dephoure, and Eduardo M. Torres

PDF

Global increase in replication fork speed during a p57KIP2-regulated erythroid cell fate switch, Yung Hwang, Melinda Futran, Daniel Hidalgo, Ramona Pop, Divya Ramalingam Iyer, Ralph Scully, Nicholas R. Rhind, and Merav Socolovsky

PDF

Actionable gene-based classification toward precision medicine in gastric cancer, Hiroshi Ichikawa, Stephen Lyle, and Toshifumi Wakai

PDF

A synthetic biology approach to probing nucleosome symmetry, Yuichi Ichikawa, Caitlin M. Connolly, Hsin-Jung Chou, Yuanyuan Chen, Upasna Sharma, Hsuiyi V. Chen, Vineeta Bajaj, Daniel Na. Bolon, Oliver J. Rando, and Paul D. Kaufman

PDF

MELK Promotes Melanoma Growth by Stimulating the NF-kappaB Pathway, Radoslav Janostiak, Navin Rauniyar, TuKiet T. Lam, Jianhong Ou, Lihua Julie Zhu, Michael R. Green, and Narendra Wajapeyee

PDF

Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1alpha, Hoe-Yune Jung, Namgyu Lee, and Kyong-Tai Kim

PDF

Regulation of the Drosophila Initiator Caspase Dronc through Ubiquitylation, Hatem E. Kamber Kaya

PDF

An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways, Hatem E. Kamber Kaya, Mark Ditzel, Pascal Meier, and Andreas Bergmann

PDF

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging, Johnathan Labbadia, Renee M. Brielmann, Mario F. Neto, Yi-Fan Lin, Cole M. Haynes, and Richard I. Morimoto

Link

Mitochondrial Sterol Oxidation Marks the Spot, Lilian Lamech and Cole M. Haynes

PDF

The Dkk3 gene encodes a vital intracellular regulator of cell proliferation, Jack L. Leonard, Deborah Marie Leonard, Scot A. Wolfe, Jilin Liu, Jaime A. Rivera-Perez, Michelle Yang, Ryan T. Leonard, Jacob P. S. Johnson, Prashant Kumar, Kate L. Liebmann, Amanda A. Tutto, Zhongming Mou, and Karl J. Simin

PDF

CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells, Haiwei Lian, Dun Li, Yun Zhou, Esther Landesman-Bollag, Guanglan Zhang, Nicole M. Anderson, Kevin Charles. Tang, Justine E. Roderick, Michelle A. Kelliher, David C. Seldin, Hui Fu, and Hui Feng

Link

Complement-Related Regulates Autophagy in Neighboring Cells, Lin Li, Frederico S. L. M. Rodrigues, Christina Kary, Alicia Contet, Mary Logan, Richard H. Baxter G, Will Wood, and Eric H. Baehrecke

PDF

Complement-Related Regulates Autophagy in Neighboring Cells, Lin Lin

PDF

A Graphene-Based Flexible Pressure Sensor with Applications to Plantar Pressure Measurement and Gait Analysis, Cunguang Lou, Shuo Wang, Tie Liang, Chenyao Pang, Lei Huang, Mingtao Run, and Xiuling Liu

Link

CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy, Leyuan Ma, Jeffrey I. Boucher, Janet L. Paulsen, Sebastian Matuszewski, Christopher A. Eide, Jianhong Ou, Garrett Eickelberg, Richard D. Press, Lihua (Julie) Zhu, Brian J. Druker, Susan Branford, Scot A. Wolfe, Jeffrey D. Jensen, Celia A. Schiffer, Michael R. Green, and Daniel N. Bolon

PDF

CAF-1 p150 and Ki-67 Regulate Nuclear Structure Throughout the Human Cell Cycle, Timothy D. Matheson

PDF

The p150N domain of chromatin assembly factor-1 regulates Ki-67 accumulation on the mitotic perichromosomal layer, Timothy D. Matheson and Paul D. Kaufman

PDF

Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia, Kate McArthur, Akshay A. D'Cruz, David Segal, Kurt Lackovic, Andrew F. Wilks, Joanne A. O'Donnell, Cameron J. Nowell, Motti Gerlic, David C. S. Huang, Christopher J. Burns, and Ben A. Croker

PDF

Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells, Jose Mercado-Matos, Jennifer L. Clark, Andrew J. Piper, Jenny Janusis, and Leslie M. Shaw

PDF

RUNX1 and breast cancer, Jose Mercado-Matos, Asia N. Matthew-Onabanjo, and Leslie M. Shaw

PDF

A Mechanistic Investigation of Insulin Receptor Substrate 2 Function in Breast Cancer Progression, Jose R. Mercado-Matos

PDF

Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis, Haiwei Mou, Jill Moore, Sunil K. Malonia, Yingxiang Li, Deniz M. Ozata, Soren Hough, Chun-Qing Song, Jordan L. Smith, Andrew H. Fischer, Zhiping Weng, Michael R. Green, and Wen Xue

PDF

CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion, Haiwei Mou, Jordan L. Smith, Lingtao Peng, Jill Moore, Xiao-Ou Zhang, Chun-Qing Song, Ankur Sheel, Deniz M. Ozata, Yingxiang Li, Charles P. Emerson Jr., Erik J. Sontheimer, Melissa J. Moore, Zhiping Weng, and Wen Xue

Link

RIPK1 mediates a disease-associated microglial response in Alzheimer's disease, Dimitry Ofengeim, Michelle A. Kelliher, and Junying Yuan

PDF

DISC1 Modulates Neuronal Stress Responses by Gate-Keeping ER-Mitochondria Ca(2+) Transfer through the MAM, Sung Jin Park, Su Been Lee, Yeongjun Suh, Su-Jeong Kim, Namgyu Lee, Ji-Ho Hong, Cana Park, Youngsik Woo, Koko Ishizuka, Joung-Hun Kim, Per-Olof Berggren, Akira Sawa, and Sang Ki Park

PDF

Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila, Ernesto Perez, Jillian L. Lindblad, and Andreas Bergmann

PDF

MicroRNAs of the mir-17~92 cluster regulate multiple aspects of pancreatic tumor development and progression, Brian J. Quattrochi, Anushree Gulvady, David R. Driscoll, Makoto Sano, David S. Klimstra, Christopher E. Turner, and Brian C. Lewis

PDF

The mitochondrial unfolded protein response: Signaling from the powerhouse, Mohammed A. Qureshi, Cole M. Haynes, and Mark W. Pellegrino

PDF

Comprehensive genomic sequencing detects important genetic differences between right-sided and left-sided colorectal cancer, Yoshifumi Shimada, Stephen Lyle, Kazuaki Takabe, and Toshifumi Wakai

PDF

Utility of comprehensive genomic sequencing for detecting HER2-positive colorectal cancer, Yoshifumi Shimada, Stephen Lyle, and Toshifumi Wakai

Link

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing, Tomer Shpilka and Cole M. Haynes

Link

Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice, Chun-Qing Song, Yingxiang Li, Haiwei Mou, Jill Moore, Angela I. Park, Soren Hough, Zachary Kennedy, Andrew H. Fischer, Darryl Conte Jr., Zhiping Weng, and Wen Xue

PDF

Ki-67 Regulates Cell Cycle Progression and Heterochromatin Organization, Xiaoming Sun

PDF

Ki-67 Contributes To Normal Cell Cycle Progression And Inactive X Heterochromatin In p21 Checkpoint-Proficient Human Cells, Xiaoming Sun, Aizhan Bizhanova, Timothy D. Matheson, Jun Yu, Lihua Julie Zhu, and Paul D. Kaufman

Link

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma, Tuomas Tammela, Wen Xue, and Tyler Jacks

PDF

Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs, Feng Wang, Kurtis N. McCannell, Ana Boskovic, Xiaochun Zhu, JongDae Shin, Jun Yu, Judith Gallant, Meg Byron, Jeanne B. Lawrence, Lihua Julie Zhu, Stephen N. Jones, Oliver J. Rando, Thomas G. Fazzio, and Ingolf Bach

PDF

Computational Investigation of Homologous Recombination DNA Repair Deficiency in Sporadic Breast Cancer, Yue Wang, Matthew H. Ung, Sharon B. Cantor, and Chao Cheng

PDF

Fundamental limits on dynamic inference from single cell snapshots, Caleb Weinreb, Samuel Wolock, Betsabeh K. Tusi, Merav Socolovsky, and Allon M. Klein

Link

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment, Georg E. Winter, Justine E. Roderick, Michelle A. Kelliher, and James E. Bradner

PDF

(CCUG)n RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis, Vildan Betul Yenigun, Mario Sirito, Alla Amcheslavsky, Tomek Czernuszewicz, Jordi Colonques-Bellmunt, Irma Garcia-Alcover, Marzena Wojciechowska, Clare Bolduc, Zhihong Chen, Arturo Lopez Castel, Ralf Krahe, and Andreas Bergmann

Link

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing, Hao Yin, Chun-Qing Song, Esther Mintzer, Mehmet F. Bolukbasi, Lihua Julie Zhu, Haiwei Mou, Suet-Yan Kwan, Scot A. Wolfe, Wen Xue, and Daniel G. Anderson

PDF

Critical role for arginase 2 in obesity-associated pancreatic cancer, Tamara Zaytouni, Pei-Yun Tsai, Daniel S. Hitchcock, Cory D. DuBois, Elizaveta Freinkman, Lin Lin, Vicente Morales-Oyarvide, Patrick J. Lenehan, Brian M. Wolpin, Mari Mino-Kenudson, Eduardo M. Torres, Nicholas Stylopoulos, Clary B. Clish, and Nada Y. Kalaany

PDF

GUIDEseq: a bioconductor package to analyze GUIDE-Seq datasets for CRISPR-Cas nucleases, Lihua Julie Zhu, Michael Lawrence, Ankit Gupta, Herve Pages, Alper Kucukural, Manuel Garber, and Scot A. Wolfe

Publications from 2016

Link

The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis, N. M. Anderson, Michelle A. Kelliher, and H. Feng

PDF

Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer, Marc A. Becker, Yasir H. Ibrahim, Annabell S. Oh, Dedra H. Fagan, Sara A. Byron, Aaron L. Sarver, Adrian V. Lee, Leslie M. Shaw, Cheng Fan, Charles M. Perou, and Douglas Yee

PDF

Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis, Michael I. Carr, Justine E. Roderick, Hugh S. Gannon, Michelle A. Kelliher, and Stephen N. Jones (Cell reports)

PDF

Requirement and Function of Hippo Pathway Signaling in the Mammalian Gastrointestinal Tract: A Dissertation, Jennifer L. Cotton