The Department of Molecular, Cell and Cancer Biology (MCCB) at the University of Massachusetts Medical School was established in 2015, and is the product of a merger between the Program in Gene Function and Expression and the Department of Cancer Biology. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Molecular, Cell and Cancer Biology. See earlier collections for selected Gene Function and Expression and Cancer Biology publications published before the departmental merger.

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Publications from 2019

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BID-ding on necroptosis in MDS, Ben A. Croker and Michelle A. Kelliher

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The Convergence of VEGF-Neuropilin and YAP/TAZ Signaling Promotes Stem-Like Traits and DNA Repair in Breast Cancer, Ameer L. Elaimy

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Which Should Be Used First for ALK-Positive Non-Small-Cell Lung Cancer: Chemotherapy or Targeted Therapy? A Meta-Analysis of Five Randomized Trials, Yen-Chien Lee, Chung-Cheng Hsieh, Yen-Ling Lee, and Chung-Yi Li

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Viral Infection or IFN-alpha Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels, William M. McDougall, Jill Perreira, Hui-Fang Hung, Anastassiia Vertii, E. Xiaofei, Wendy Zimmerman, Timothy F. Kowalik, Stephen J. Doxsey, and Abraham L. Brass

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VEGF/Neuropilin Signaling in Cancer Stem Cells, Arthur M. Mercurio

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The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans, Nicholas D. Peterson, Hilary K. Cheesman, Pengpeng Liu, Sarah M. Anderson, Kyle J. Foster, Richa Chhaya, Paola N. Perrat, Jose Thekkiniath, Qiyuan Yang, Cole M. Haynes, and Read Pukkila-Worley

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Brown fat organogenesis and maintenance requires AKT1 and AKT2, Joan Sanchez-Gurmaches, Camila Martinez Calejman, Su Myung Jung, Huawei Li, and David A. Guertin

Publications from 2018

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NmeCas9 is an intrinsically high-fidelity genome editing platform, Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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NmeCas9 is an intrinsically high-fidelity genome-editing platform, Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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Are membranes non-apoptotic compartments for apoptotic caspases, Andreas Bergmann

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Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing, Mehmet F. Bolukbasi, Pengpeng Liu, Kevin Luk, Samantha F. Kwok, Ankit Gupta, Nadia Amrani, Erik J. Sontheimer, Lihua Julie Zhu, and Scot A. Wolfe

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Cell clustering mediated by the adhesion protein PVRL4 is necessary for alpha6beta4 integrin-promoted ferroptosis resistance in matrix-detached cells, Caitlin W. Brown, John J. Amante, and Arthur M. Mercurio

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Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis, Qingbo Chen, Lei Huang, Dongning Pan, Lihua (Julie) Zhu, and Yong-Xu Wang

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RUNX1 Is an Oncogenic Transcription Factor that Regulates MYB and MYC Enhancer Activity in T-ALL, AHyun Choi

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SERINC5: Its Sensitivity to Nef and Restriction of HIV-1, Weiwei Dai

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A Long Cytoplasmic Loop Governs the Sensitivity of the Anti-viral Host Protein SERINC5 to HIV-1 Nef, Weiwei Dai, Yoshiko Usami, Yuanfei Wu, and Heinrich G. Gottlinger

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VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP beta2-chimaerin, Ameer L. Elaimy, Santosh Guru, Cheng Chang, Jianhong Ou, John J. Amante, Lihua Julie Zhu, Hira Lal Goel, and Arthur M. Mercurio

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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018, Lorenzo Galluzzi, Eric H. Baehrecke, Francis Ka-Ming Chan, and Guido Kroemer

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C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2, Xin D. Gao, Li-Chun Tu, Aamir Mir, Tomas Rodriguez, Yue-He Ding, John D. Leszyk, Job Dekker, Scott A. Shaffer, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer (Nature methods, 2018-05-07)

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C-BERST: Defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2, Xin D. Gao, Li-Chun Tu, Aamir Mir, Tomas Rodriguez, Yue-He Ding, John D. Leszyk, Job Dekker, Scott A. Shaffer, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays, Yingying Geng, Hira Lal Goel, Ngoc B. Le, Tatsuyuki Yoshii, Rubul Mout, Gulen Y. Tonga, John J. Amante, Arthur M. Mercurio, and Vincent M. Rotello

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A large-scale RNA interference screen identifies genes that regulate autophagy at different stages, Sujuan Guo, Kevin J. Pridham, Ching-Man A. Virbasius, Bin He, Liqing Zhang, Hanne Varmark, Michael R. Green, and Zhi Sheng

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Identification of Epigenetic Regulators of DUX4-fl for Targeted Therapy of Facioscapulohumeral Muscular Dystrophy, Charis L. Himeda, Takako I. Jones, Ching-Man A. Virbasius, Lihua Julie Zhu, Michael R. Green, and Peter L. Jones

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UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response, L. N. Huiting, Y. Samaha, G. L. Zhang, Justine E. Roderick, B. Li, N. M. Anderson, Y. W. Wang, L. Wang, F. Laroche, J. W. Choi, C. T. Liu, Michelle A. Kelliher, and H. Feng

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Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants, Govind Kunduri, Daniel Turner-Evans, Yutaka Konya, Yoshihiro Izumi, Kunio Nagashima, Stephen Lockett, Joost Holthuis, Takeshi Bamba, Usha Acharya, and Jairaj K. Acharya

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Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells, Benjamin D. Landry, Thomas Leete, Ryan Richards, Peter Cruz-Gordillo, Hannah R. Schwartz, Megan E. Honeywell, Gary Ren, Alyssa D. Schwartz, Shelly R. Peyton, and Michael J. Lee (Molecular systems biology, 2018-08-06)

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Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins, Jooyoung Lee, Aamir Mir, Alireza Edraki, Bianca Garcia, Nadia Amrani, Hannah E. Lou, Ildar Gainetdinov, April Pawluk, Raed Ibraheim, Xin D. Gao, Pengpeng Liu, Alan R. Davidson, Karen L. Maxwell, and Erik J. Sontheimer

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Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth, Qi Li, Niraj K. Nirala, Yingchao Nie, Hsi-Ju Chen, Gary R. Ostroff, Junhao Mao, Qi Wang, Lan Xu, and Y. Tony Ip

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Dynamic Balance Measurement and Quantitative Assessment Using Wearable Plantar-Pressure Insoles in a Pose-Sensed Virtual Environment, Cunguang Lou, Chenyao Pang, Congrui Jing, Shuo Wang, Xufeng He, Xiaoguang Liu, Lei Huang, Feng Lin, Xiuling Liu, and Hongrui Wang

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Identification of Deubiquitinating Enzymes that Control the Cell Cycle in Saccharomyces cerevisiae, Claudine E. Mapa

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Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2, Jose Mercado-Matos, Jenny Janusis, Sha Zhu, Samuel S. Chen, and Leslie M. Shaw

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Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing, Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts, and Erik J. Sontheimer

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Heavily and Fully Modified RNAs Guide Efficient SpyCas9-Mediated Genome Editing, Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts, and Erik J. Sontheimer

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The NF-kappaB Factor Relish Regulates Atg1 Expression and Controls Autophagy, Anubhab Nandy, Lin Lin, Panagiotis D. Velentzas, Louisa P. Wu, Eric H. Baehrecke, and Neal S. Silverman

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ATACseqQC: a Bioconductor package for post-alignment quality assessment of ATAC-seq data, Jianhong Ou, Haibo Liu, Jun Yu, Michelle A. Kelliher, Lucio H. Castilla, Nathan D. Lawson, and Lihua Julie Zhu

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Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress, Min Peng, Ke Cong, Nicholas J. Panzarino, Sumeet Nayak, Jennifer Calvo, Bin Deng, Lihua Julie Zhu, Monika Morocz, Lili Hegedus, Lajos Haracska, and Sharon B. Cantor

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Mitochondrial Biogenesis: MitoCPR Resuscitates Import-Defective Mitochondria, Jacqueline Pires and Cole M. Haynes

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Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia, John A. Pulikkan and Lucio H. Castilla

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CBFbeta-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia, John A. Pulikkan, Mahesh Hegde, Hafiz Mohd Ahmad, Houda Belaghzal, Anuradha Illendula, Jun Yu, Kelsey O'Hagan, Jianhong Ou, Carsten Muller-Tidow, Scot A. Wolfe, Lihua J. Zhu, Job Dekker, John Hackett Bushweller, and Lucio H. Castilla (Cell, 2018-06-28)

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IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer, Sanjoy Samanta, Santosh Guru, Ameer L. Elaimy, John J. Amante, Jianhong Ou, Jun Yu, Lihua Julie Zhu, and Arthur M. Mercurio

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IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer, Sanjoy Samanta, Santosh Guru, Ameer L. Elaimy, John J. Amante, Jianhong Ou, Jun Yu, Lihua Julie Zhu, and Arthur M. Mercurio

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Impact of Concurrent Genomic Alterations Detected by Comprehensive Genomic Sequencing on Clinical Outcomes in East-Asian Patients with EGFR-Mutated Lung Adenocarcinoma, Seijiro Sato, Stephen Lyle, Toshifumi Wakai, and Masanori Tsuchida

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Metabolic shift from glycogen to trehalose promotes lifespan and healthspan in Caenorhabditis elegans, Yonghak Seo, Samuel F. Kingsley, Griffin Walker, Michelle A. Mondoux, and Heidi A. Tissenbaum

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Understanding and repurposing CRISPR-mediated alternative splicing, Jordan L. Smith, Haiwei Mou, and Wen Xue

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In vivo genome editing partially restores alpha1-antitrypsin in a murine model of AAT deficiency, Chun-Qing Song, Dan Wang, Tingting Jiang, Kevin O'Connor, Qiushi Tang, Lingling Cai, Xiangrui Li, Zhiping Weng, Hao Yin, Guangping Gao, Christian Mueller, Terence R. Flotte, and Wen Xue

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Emergence of the erythroid lineage from multipotent hematopoiesis, Betsabeh K. Tusi, Samuel L. Wolock, Caleb Weinreb, Yung Hwang, Daniel Hidalgo, Rapolas Zilionis, Ari Waisman, Jun R. Huh, Allon M. Klein, and Merav Socolovsky

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YAP drives cutaneous squamous cell carcinoma formation and progression, Zoe Vincent-Mistiaen, Ahmed Elbediwy, Hannah Vanyai, Jennifer L. Cotton, Gordon Stamp, Emma Nye, Bradley Spencer-Dene, Gareth J. Thomas, Junhao Mao, and Barry Thompson

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Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging, Chuangqi Wang, Hee June Choi, Sung-Jin Kim, Aesha Desai, Namgyu Lee, Dohoon Kim, Yongho Bae, and Kwonmoo Lee

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Deconvolution Of Subcellular Protrusion Heterogeneity And The Underlying Actin Regulator Dynamics From Live Cell Imaging, Chuangqi Wang, Hee June Choi, Sung-Jin Kim, Aesha Desai, Namgyu Lee, Dohoon Kim, Yongho Bae, and Kwonmoo Lee

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The Dynamic Roles of Mesenchymal Stem Cells in Colon Cancer, Shan Wang, Zhiguo Miao, Qiyuan Yang, Yimin Wang, and Jinzhou Zhang

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Partial DNA-guided Cas9 enables genome editing with reduced off-target activity, Hao Yin, Chun-Qing Song, Sneha Suresh, Suet-Yan Kwan, Qiongqiong Wu, Stephen Walsh, Junmei Ding, Roman L. Bogorad, Lihua Julie Zhu, Scot A. Wolfe, Victor Koteliansky, Wen Xue, Robert Langer, and Daniel G. Anderson

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The Role of RIPK1 Kinase Activity in Regulating Inflammation and Necroptotic Death, Matija Zelic

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RIP kinase 1-dependent endothelial necroptosis underlies systemic inflammatory response syndrome, Matija Zelic, Justine E. Roderick, Joanne A. O'Donnell, Jesse Lehman, Sung Eun Lim, Harish P. Janardhan, Chinmay M. Trivedi, Manolis Pasparakis, and Michelle A. Kelliher

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The temporal landscape of recursive splicing during Pol II transcription elongation in human cells, Xiao-Ou Zhang, Yu Fu, Haiwei Mou, Wen Xue, and Zhiping Weng

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IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma, Sha Zhu, B. Marie Ward, Jun Yu, Asia N. Matthew-Onabanjo, Jenny Janusis, Chung-Cheng Hsieh, Keith Tomaszewicz, Lloyd Hutchinson, Lihua Julie Zhu, Dina Kandil, and Leslie M. Shaw

Publications from 2017

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Understanding Multiple Independent Functions of the Tip60 Acetyltransferase in Embryonic Development, Diwash Acharya

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Cleaning House: Selective Autophagy of Organelles, Allyson L. Anding and Eric H. Baehrecke

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Development of Chimeric Cas9 Nucleases for Accurate and Flexible Genome Editing, Mehmet F. Bolukbasi

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A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival, Elias Bou Samra, Geraldine Buhagiar-Labarchede, Christelle Machon, Jerome Guitton, Rosine Onclercq-Delic, Michael R. Green, Olivier Alibert, Claude Gazin, Xavier Veaute, and Mounira Amor-Gueret

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The alpha6beta4 integrin promotes resistance to ferroptosis, Caitlin W. Brown, John J. Amante, Hira Lal Goel, and Arthur M. Mercurio

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Molecular Basis and Targeted Inhibition of CBFbeta-SMMHC Acute Myeloid Leukemia, Lucio H. Castilla and John H. Bushweller

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RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia, AHyun Choi, Anuradha Illendula, John A. Pulikkan, Justine E. Roderick, Jessica M. Tesell, Jun Yu, Nicole M. Hermance, Lihua (Julie) Zhu, Lucio H. Castilla, John H. Bushweller, and Michelle A. Kelliher

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JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias, C. Delgado-Martin, L. K. Meyer, B. J. Huang, M. S. Zinter, J. V. Nguyen, G. A. Smith, J. Taunton, S. S. Winter, Justine R. Roderick, Michelle A. Kelliher, T. M. Horton, B. L. Wood, D. T. Teachey, and M. L. Hermiston

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Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR, Pan Deng and Cole M. Haynes

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Regulation of Pluripotency and Differentiation by Chromatin Remodeling Factors, Ly-Sha Ee

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Clinical application of a cancer genomic profiling assay to guide precision medicine decisions, Cheryl Eifert, Angeliki Pantazi, Ruobai Sun, Jia Xu, Pablo Cingolani, Joerg Heyer, Meaghan Russell, Maria Lvova, Jennifer Ring, Julie Y. Tse, Stephen Lyle, and Alexei Protopopov

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Integrating the UPRmt into the mitochondrial maintenance network, Christopher J. Fiorese and Cole M. Haynes

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Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease, Caitlin E. Fogarty and Andreas Bergmann

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Molecular definitions of autophagy and related processes, Lorenzo Galluzzi, Eric H. Baehrecke, and Guido Kroemer

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Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation, Lei Huang, Dongning Pan, Qingbo Chen, Lihua (Julie) Zhu, Jianhong Ou, Martin Wabitsch, and Yong-Xu Wang

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Serine-Dependent Sphingolipid Synthesis Is a Metabolic Liability of Aneuploid Cells, Sunyoung Hwang, H. Tobias Gustafsson, Ciara O'Sullivan, Gianna Bisceglia, Xinhe Huang, Christian Klose, Andrej Schevchenko, Robert C. Dickson, Paola Cavaliere, Noah Dephoure, and Eduardo M. Torres

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Global increase in replication fork speed during a p57KIP2-regulated erythroid cell fate switch, Yung Hwang, Melinda Futran, Daniel Hidalgo, Ramona Pop, Divya Ramalingam Iyer, Ralph Scully, Nicholas R. Rhind, and Merav Socolovsky

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Actionable gene-based classification toward precision medicine in gastric cancer, Hiroshi Ichikawa, Stephen Lyle, and Toshifumi Wakai

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A synthetic biology approach to probing nucleosome symmetry, Yuichi Ichikawa, Caitlin M. Connolly, Hsin-Jung Chou, Yuanyuan Chen, Upasna Sharma, Hsuiyi V. Chen, Vineeta Bajaj, Daniel Na. Bolon, Oliver J. Rando, and Paul D. Kaufman

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MELK Promotes Melanoma Growth by Stimulating the NF-kappaB Pathway, Radoslav Janostiak, Navin Rauniyar, TuKiet T. Lam, Jianhong Ou, Lihua Julie Zhu, Michael R. Green, and Narendra Wajapeyee

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Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1alpha, Hoe-Yune Jung, Namgyu Lee, and Kyong-Tai Kim

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Regulation of the Drosophila Initiator Caspase Dronc through Ubiquitylation, Hatem E. Kamber Kaya

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An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways, Hatem E. Kamber Kaya, Mark Ditzel, Pascal Meier, and Andreas Bergmann

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Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging, Johnathan Labbadia, Renee M. Brielmann, Mario F. Neto, Yi-Fan Lin, Cole M. Haynes, and Richard I. Morimoto

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Mitochondrial Sterol Oxidation Marks the Spot, Lilian Lamech and Cole M. Haynes

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The Dkk3 gene encodes a vital intracellular regulator of cell proliferation, Jack L. Leonard, Deborah Marie Leonard, Scot A. Wolfe, Jilin Liu, Jaime A. Rivera-Perez, Michelle Yang, Ryan T. Leonard, Jacob P. S. Johnson, Prashant Kumar, Kate L. Liebmann, Amanda A. Tutto, Zhongming Mou, and Karl J. Simin

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CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells, Haiwei Lian, Dun Li, Yun Zhou, Esther Landesman-Bollag, Guanglan Zhang, Nicole M. Anderson, Kevin Charles. Tang, Justine E. Roderick, Michelle A. Kelliher, David C. Seldin, Hui Fu, and Hui Feng

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Complement-Related Regulates Autophagy in Neighboring Cells, Lin Li, Frederico S. L. M. Rodrigues, Christina Kary, Alicia Contet, Mary Logan, Richard H. Baxter G, Will Wood, and Eric H. Baehrecke

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Complement-Related Regulates Autophagy in Neighboring Cells, Lin Lin

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A Graphene-Based Flexible Pressure Sensor with Applications to Plantar Pressure Measurement and Gait Analysis, Cunguang Lou, Shuo Wang, Tie Liang, Chenyao Pang, Lei Huang, Mingtao Run, and Xiuling Liu

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CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy, Leyuan Ma, Jeffrey I. Boucher, Janet L. Paulsen, Sebastian Matuszewski, Christopher A. Eide, Jianhong Ou, Garrett Eickelberg, Richard D. Press, Lihua (Julie) Zhu, Brian J. Druker, Susan Branford, Scot A. Wolfe, Jeffrey D. Jensen, Celia A. Schiffer, Michael R. Green, and Daniel N. Bolon

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CAF-1 p150 and Ki-67 Regulate Nuclear Structure Throughout the Human Cell Cycle, Timothy D. Matheson

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The p150N domain of chromatin assembly factor-1 regulates Ki-67 accumulation on the mitotic perichromosomal layer, Timothy D. Matheson and Paul D. Kaufman

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Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia, Kate McArthur, Akshay A. D'Cruz, David Segal, Kurt Lackovic, Andrew F. Wilks, Joanne A. O'Donnell, Cameron J. Nowell, Motti Gerlic, David C. S. Huang, Christopher J. Burns, and Ben A. Croker

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Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells, Jose Mercado-Matos, Jennifer L. Clark, Andrew J. Piper, Jenny Janusis, and Leslie M. Shaw

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RUNX1 and breast cancer, Jose Mercado-Matos, Asia N. Matthew-Onabanjo, and Leslie M. Shaw

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A Mechanistic Investigation of Insulin Receptor Substrate 2 Function in Breast Cancer Progression, Jose R. Mercado-Matos

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Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis, Haiwei Mou, Jill Moore, Sunil K. Malonia, Yingxiang Li, Deniz M. Ozata, Soren Hough, Chun-Qing Song, Jordan L. Smith, Andrew H. Fischer, Zhiping Weng, Michael R. Green, and Wen Xue

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CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion, Haiwei Mou, Jordan L. Smith, Lingtao Peng, Jill Moore, Xiao-Ou Zhang, Chun-Qing Song, Ankur Sheel, Deniz M. Ozata, Yingxiang Li, Charles P. Emerson Jr., Erik J. Sontheimer, Melissa J. Moore, Zhiping Weng, and Wen Xue

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RIPK1 mediates a disease-associated microglial response in Alzheimer's disease, Dimitry Ofengeim, Michelle A. Kelliher, and Junying Yuan

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DISC1 Modulates Neuronal Stress Responses by Gate-Keeping ER-Mitochondria Ca(2+) Transfer through the MAM, Sung Jin Park, Su Been Lee, Yeongjun Suh, Su-Jeong Kim, Namgyu Lee, Ji-Ho Hong, Cana Park, Youngsik Woo, Koko Ishizuka, Joung-Hun Kim, Per-Olof Berggren, Akira Sawa, and Sang Ki Park

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Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila, Ernesto Perez, Jillian L. Lindblad, and Andreas Bergmann

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MicroRNAs of the mir-17~92 cluster regulate multiple aspects of pancreatic tumor development and progression, Brian J. Quattrochi, Anushree Gulvady, David R. Driscoll, Makoto Sano, David S. Klimstra, Christopher E. Turner, and Brian C. Lewis

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The mitochondrial unfolded protein response: Signaling from the powerhouse, Mohammed A. Qureshi, Cole M. Haynes, and Mark W. Pellegrino

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Comprehensive genomic sequencing detects important genetic differences between right-sided and left-sided colorectal cancer, Yoshifumi Shimada, Stephen Lyle, Kazuaki Takabe, and Toshifumi Wakai