The Department of Molecular, Cell and Cancer Biology (MCCB) at the University of Massachusetts Medical School was established in 2015, and is the product of a merger between the Program in Gene Function and Expression and the Department of Cancer Biology. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Molecular, Cell and Cancer Biology. See earlier collections for selected Gene Function and Expression and Cancer Biology publications published before the departmental merger.

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Publications from 2020

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Tumor cell-organized fibronectin maintenance of a dormant breast cancer population, Lauren E. Barney, Christopher L. Hall, Alyssa D. Schwartz, Akia N. Parks, Christopher Sparages, Sualyneth Galarza, Manu O. Platt, Arthur M. Mercurio, and Shelly R. Peyton

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mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis, Camila Martinez Calejman, S. Trefely, S. W. Entwisle, Amelia K. Luciano, Su Myung. Jung, Wen-Yu Hsiao, A. Torres, C. M. Hung, H. Li, N. W. Snyder, J. Villen, K. E. Wellen, and David A. Guertin

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Innate Immunity in the C. elegans Intestine Is Programmed by a Neuronal Regulator of AWC Olfactory Neuron Development, Kyle J. Foster, Hilary K. Cheesman, Pengpeng Liu, Nicholas D. Peterson, Sarah M. Anderson, and Read Pukkila-Worley

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NCAPG Dynamically Coordinates the Myogenesis of Fetal Bovine Tissue by Adjusting Chromatin Accessibility, Xin Hu, Yishen Xing, Xing Fu, Qiyuan Yang, Ling Ren, Yahui Wang, Qian Li, Junya Li, and Lupei Zhang

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Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope, Tingting Jiang, Xiao-Ou Zhang, Yueying Cao, Zhiping Weng, and Wen Xue

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The coordinate actions of calcineurin and Hog1 mediate the stress response through multiple nodes of the cell cycle network, Cassandra M. Leech, Mackenzie J. Flynn, Heather E. Arsenault, Jianhong Ou, Haibo Liu, Lihua Julie Zhu, and Jennifer A. Benanti

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Beclin 1 Promotes Endosome Recruitment of Hepatocyte Growth Factor Tyrosine Kinase Substrate to Suppress Tumor Proliferation, Asia N. Matthew-Onabanjo, Jenny Janusis, Jose Mercado-Matos, Anne E. Carlisle, Dohoon Kim, Fayola Levine, Peter Cruz-Gordillo, Ryan Richards, Michael J. Lee, and Leslie M. Shaw (Cancer research, 2020-01-15)

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Adenine base editing in an adult mouse model of tyrosinaemia, Chun-Qing Song, Tingting Jiang, Michelle Richter, Luke H. Rhym, Luke W. Koblan, Maria Paz Zafra, Emma M. Schatoff, Jordan L. Doman, Yueying Cao, Lukas E. Dow, Lihua Julie Zhu, Daniel G. Anderson, David R. Liu, Hao Yin, and Wen Xue

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Gender Identity and Sexual Orientation Identity in Women and Men Prenatally Exposed to Diethylstilbestrol, Rebecca Troisi, Julie R. Palmer, Elizabeth E. Hatch, William C. Strohsnitter, Dezheng Huo, Marianne Hyer, Karen I. Fredriksen-Goldsen, Robert Hoover, and Linda Titus

Publications from 2019

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Benign ethnic neutropenia, Suheil Albert Atallah-Yunes, Audrey Ready, and Peter E. Newburger

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Tumor cell-organized fibronectin is required to maintain a dormant breast cancer population, Lauren E. Barney, Christopher L. Hall, Alyssa D. Schwartz, Akia N. Parks, Christopher Sparages, Sualyneth Galarza, Manu O. Platt, Arthur M. Mercurio, and Shelly R. Peyton

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BID-ding on necroptosis in MDS, Ben A. Croker and Michelle A. Kelliher

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Mitochondrial UPR repression during Pseudomonas aeruginosa infection requires the bZIP protein ZIP-3, Pan Deng, Nandhitha Uma Naresh, Yunguang Du, Lilian T. Lamech, Jun Yu, Lihua Julie Zhu, Read Pukkila-Worley, and Cole M. Haynes

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The Convergence of VEGF-Neuropilin and YAP/TAZ Signaling Promotes Stem-Like Traits and DNA Repair in Breast Cancer, Ameer L. Elaimy

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Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B, Xin Hu, Yishen Xing, Ling Ren, Yahui Wang, Qian Li, Xing Fu, Qiyuan Yang, Lingyang Xu, Luc Willems, Junya Li, and Lupei Zhang

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Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells, Sunyoung Hwang, Jessica F. Williams, Maja Kneissig, Maria Lioudyno, Isabel Rivera, Pablo Helguera, Jorge Busciglio, Zuzana Storchova, Megan C. King, and Eduardo M. Torres

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The Role of S-phase Speed During an Erythroid Transcriptional Switch, Yung Hwang

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Precise therapeutic gene correction by a simple nuclease-induced double-stranded break, Sukanya Iyer, Sneha Suresh, Dongsheng Guo, Katelyn Daman, Jennifer C. J. Chen, Pengpeng Liu, Marina Zieger, Kevin Luk, Benjamin P. Roscoe, Christian Mueller, Oliver D. King, Charles P. Emerson Jr., and Scot A. Wolfe

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Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity, Steven W. Jin, Nirmin Alsahafi, Xiaomei T. Kuang, Shayda A. Swann, Mako Toyoda, Heinrich G. Gottlinger, Bruce D. Walker, Takamasa Ueno, Andres Finzi, Zabrina L. Brumme, and Mark A. Brockman

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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1, Su Myung Jung, Chien-Min Hung, Samuel R. Hildebrand, Joan Sanchez-Gurmaches, Dimpi Mukhopadhyay, Camila Martinez Calejman, Amelia K. Luciano, Wen-Yu Hsiao, Yuefeng Tang, Huawei Li, and David A. Guertin

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Depletion of TRRAP induces p53-independent senescence in liver cancer by downregulating mitotic genes, Suet-Yan Kwan, Ankur Sheel, Chun-Qing Song, Xiao-Ou Zhang, Tingting Jiang, Hien Dang, Yueying Cao, Deniz M. Ozata, Haiwei Mou, Hao Yin, Zhiping Weng, Xin Wei Wang, and Wen Xue

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Tissue-restricted genome editing in vivo specified by microRNA-repressible anti-CRISPR proteins, Jooyoung Lee, Haiwei Mou, Raed Ibraheim, Shun-Qing Liang, Pengpeng Liu, Wen Xue, and Erik J. Sontheimer

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Which Should Be Used First for ALK-Positive Non-Small-Cell Lung Cancer: Chemotherapy or Targeted Therapy? A Meta-Analysis of Five Randomized Trials, Yen-Chien Lee, Chung-Cheng Hsieh, Yen-Ling Lee, and Chung-Yi Li

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Entosis Controls a Developmental Cell Clearance in C. elegans, Yongchan Lee, Jens C. Hamann, Mark Pellegrino, Joanne Durgan, Marie-Charlotte Domart, Lucy M. Collinson, Cole M. Haynes, Oliver Florey, and Michael Overholtzer

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The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation, Dongfang Li, Yan G. Zhao, Di Li, Hongyu Zhao, Jie Huang, Guangyan Miao, Du Feng, Pingsheng Liu, Dong Li, and Hong Zhang

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YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression, Huapeng Li, Qi Li, Kyvan Dang, Shan Ma, Jennifer L. Cotton, Sun Yang, Lihua Julie Zhu, April C. Deng, Y. Tony Ip, Randy L. Johnson, Xu Wu, Claudio Punzo, and Junhao Mao

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The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium, Qi Li, Niraj K. Nirala, Hsi-Ju Chen, Yingchao Nie, Wei Wang, Biliang Zhang, Michael P. Czech, Qi Wang, Lan Xu, Junhao Mao, and Y. Tony Ip

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Prosurvival kinase PIM2 is a therapeutic target for eradication of chronic myeloid leukemia stem cells, Leyuan Ma, Magnolia L. Pak, Jianhong Ou, Jun Yu, Pamela St Louis, Yi Shan, Lloyd Hutchinson, Shaoguang Li, Michael A. Brehm, Lihua Julie Zhu, and Michael R. Green

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An order-to-disorder structural switch activates the FoxM1 transcription factor, Aimee H. Marceau, Caileen M. Brison, Santrupti Nerli, Heather E. Arsenault, Andrew C. McShan, Eefei Chen, Hsiau-Wei Lee, Jennifer A. Benanti, Nikolaos G. Sgourakis, and Seth M. Rubin

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Novel Insight into the Autophagy-Independent Functions of Beclin 1 in Tumor Growth, Asia N. Matthew-Onabanjo

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Viral Infection or IFN-alpha Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels, William M. McDougall, Jill Perreira, Hui-Fang Hung, Anastassiia Vertii, E. Xiaofei, Wendy Zimmerman, Timothy F. Kowalik, Stephen J. Doxsey, and Abraham L. Brass

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VEGF/Neuropilin Signaling in Cancer Stem Cells, Arthur M. Mercurio

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Genome editing of HBG1 and HBG2 to induce fetal hemoglobin, Jean-Yves Metais, Kevin Luk, Scot A. Wolfe, Shengdar Q. Tsai, and Mitchell J. Weiss

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A critical role of VMP1 in lipoprotein secretion, Hideaki Morishita, Yan G. Zhao, Norito Tamura, Taki Nishimura, Yuki Kanda, Yuriko Sakamaki, Mitsuyo Okazaki, Dongfang Li, and Noboru Mizushima

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CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling, Haiwei Mou, Deniz M. Ozata, Jordan L. Smith, Ankur Sheel, Suet-Yan Kwan, Soren Hough, Alper Kucukural, Zachary Kennedy, Yueying Cao, and Wen Xue

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Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection, James D. Nhan, Christian D. Turner, Sarah M. Anderson, Chia-An Yen, Hans M. Dalton, Hilary K. Cheesman, Dana L. Ruter, Nandhitha Uma Naresh, Cole M. Haynes, Alexander A. Soukas, Read Pukkila-Worley, and Sean P. Curran

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Sptlc1 is essential for myeloid differentiation and hematopoietic homeostasis, Velayoudame Parthibane, Usha Acharya, and Jairaj K. Acharya

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F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear beta-catenin function, Debasish Paul, Sehbanul Islam, Rajesh Kumar. Manne, U. S. Dinesh, Sunil K. Malonia, Biswanath Maity, Ramanamurthy Boppana, Srikanth Rapole, Praveen Kumar Shetty, and Manas Kumar Santra

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Enhanced Cas12a editing in mammalian cells and zebrafish, Pengpeng Liu, Kevin Luk, Masahiro Shin, Feston Idrizi, Samantha F. Kwok, Benjamin P. Roscoe, Esther Mintzer, Sneha Suresh, Kyle Morrison, Josias B. Frazao, Mehmet Fatih Bolukbasi, Karthikeyan Ponnienselvan, Jeremy Luban, Lihua Julie Zhu, Nathan D. Lawson, and Scot A. Wolfe

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The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans, Nicholas D. Peterson, Hilary K. Cheesman, Pengpeng Liu, Sarah M. Anderson, Kyle J. Foster, Richa Chhaya, Paola N. Perrat, Jose Thekkiniath, Qiyuan Yang, Cole M. Haynes, and Read Pukkila-Worley

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Insulin Receptor Substrate-1 (IRS-1) and IRS-2 expression levels are associated with prognosis in non-small cell lung cancer (NSCLC), Andrew J. Piper, Jennifer L. Clark, Jose R. Mercado-Matos, Asia N. Matthew-Onabanjo, Chung-Cheng Hsieh, Ali Akalin, and Leslie M. Shaw

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Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia, Gayle P. Pouliot, Justine E. Roderick, and Alejandro Gutierrez

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Brown fat organogenesis and maintenance requires AKT1 and AKT2, Joan Sanchez-Gurmaches, Camila Martinez Calejman, Su Myung Jung, Huawei Li, and David A. Guertin

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MTF1, a classic metal sensing transcription factor, promotes myogenesis in response to copper, Cristina Tavera-Montañez, Sarah J. Hainer, Daniella Cangussu, Shellaina J. V. Gordon, Yao Xiao, Pablo Reyes-Gutierrez, Anthony N. Imbalzano, Juan G. Navea, Thomas G. Fazzio, and Teresita Padilla-Benavides

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Dietary alpha-ketoglutarate promotes beige adipogenesis and prevents obesity in middle-aged mice, Qiyu Tian, Junxing Zhao, Qiyuan Yang, Bo Wang, Jeanene M. Deavila, Mei-Jun Zhu, and Min Du

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alphavbeta3 Integrin Mediates Radioresistance of Prostate Cancer Cells Through Regulation of Survivin, Tao Wang, Jiayi Huang, Mai Vue, Michael R. Alavian, Hira Lal Goel, Dario C. Altieri, Lucia R. Languino, and Thomas J. Fitzgerald

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Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis, Weicang Wang, Jun Yang, Matthew L. Edin, Yuxin Wang, Ying Luo, Debin Wan, Haixia Yang, Chun-Qing Song, Wen Xue, Katherine Z. Sanidad, Mingyue Song, Heather A. Bisbee, Jennifer A. Bradbury, Guanjun Nan, Jianan Zhang, Pei-An Betty Shih, Kin Sing Stephen Lee, Lisa M. Minter, Daeyoung Kim, Hang Xiao, Jun-Yan Liu, Bruce D. Hammock, Darryl C. Zeldin, and Guodong Zhang

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RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-kappaB Activation, Jerry Wong, Matija Zelic, John Bertin, Michelle A. Kelliher, and Monica Guma

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Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5, Yuanfei Wu, Balaji Olety, Eric R. Weiss, Elena Popova, Hikaru Yamanaka, and Heinrich G. Gottlinger

Publications from 2018

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NmeCas9 is an intrinsically high-fidelity genome editing platform, Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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NmeCas9 is an intrinsically high-fidelity genome-editing platform, Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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Are membranes non-apoptotic compartments for apoptotic caspases, Andreas Bergmann

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Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing, Mehmet F. Bolukbasi, Pengpeng Liu, Kevin Luk, Samantha F. Kwok, Ankit Gupta, Nadia Amrani, Erik J. Sontheimer, Lihua Julie Zhu, and Scot A. Wolfe

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Cell clustering mediated by the adhesion protein PVRL4 is necessary for alpha6beta4 integrin-promoted ferroptosis resistance in matrix-detached cells, Caitlin W. Brown, John J. Amante, and Arthur M. Mercurio

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Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis, Qingbo Chen, Lei Huang, Dongning Pan, Lihua (Julie) Zhu, and Yong-Xu Wang

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RUNX1 Is an Oncogenic Transcription Factor that Regulates MYB and MYC Enhancer Activity in T-ALL, AHyun Choi

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SERINC5: Its Sensitivity to Nef and Restriction of HIV-1, Weiwei Dai

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A Long Cytoplasmic Loop Governs the Sensitivity of the Anti-viral Host Protein SERINC5 to HIV-1 Nef, Weiwei Dai, Yoshiko Usami, Yuanfei Wu, and Heinrich G. Gottlinger

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VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP beta2-chimaerin, Ameer L. Elaimy, Santosh Guru, Cheng Chang, Jianhong Ou, John J. Amante, Lihua Julie Zhu, Hira Lal Goel, and Arthur M. Mercurio

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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018, Lorenzo Galluzzi, Eric H. Baehrecke, Francis Ka-Ming Chan, and Guido Kroemer

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C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2, Xin D. Gao, Li-Chun Tu, Aamir Mir, Tomas Rodriguez, Yue-He Ding, John D. Leszyk, Job Dekker, Scott A. Shaffer, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer (Nature methods, 2018-05-07)

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C-BERST: Defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2, Xin D. Gao, Li-Chun Tu, Aamir Mir, Tomas Rodriguez, Yue-He Ding, John D. Leszyk, Job Dekker, Scott A. Shaffer, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays, Yingying Geng, Hira Lal Goel, Ngoc B. Le, Tatsuyuki Yoshii, Rubul Mout, Gulen Y. Tonga, John J. Amante, Arthur M. Mercurio, and Vincent M. Rotello

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A large-scale RNA interference screen identifies genes that regulate autophagy at different stages, Sujuan Guo, Kevin J. Pridham, Ching-Man A. Virbasius, Bin He, Liqing Zhang, Hanne Varmark, Michael R. Green, and Zhi Sheng

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Identification of Epigenetic Regulators of DUX4-fl for Targeted Therapy of Facioscapulohumeral Muscular Dystrophy, Charis L. Himeda, Takako I. Jones, Ching-Man A. Virbasius, Lihua Julie Zhu, Michael R. Green, and Peter L. Jones

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UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response, L. N. Huiting, Y. Samaha, G. L. Zhang, Justine E. Roderick, B. Li, N. M. Anderson, Y. W. Wang, L. Wang, F. Laroche, J. W. Choi, C. T. Liu, Michelle A. Kelliher, and H. Feng

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Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants, Govind Kunduri, Daniel Turner-Evans, Yutaka Konya, Yoshihiro Izumi, Kunio Nagashima, Stephen Lockett, Joost Holthuis, Takeshi Bamba, Usha Acharya, and Jairaj K. Acharya

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Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells, Benjamin D. Landry, Thomas Leete, Ryan Richards, Peter Cruz-Gordillo, Hannah R. Schwartz, Megan E. Honeywell, Gary Ren, Alyssa D. Schwartz, Shelly R. Peyton, and Michael J. Lee (Molecular systems biology, 2018-08-06)

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Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins, Jooyoung Lee, Aamir Mir, Alireza Edraki, Bianca Garcia, Nadia Amrani, Hannah E. Lou, Ildar Gainetdinov, April Pawluk, Raed Ibraheim, Xin D. Gao, Pengpeng Liu, Alan R. Davidson, Karen L. Maxwell, and Erik J. Sontheimer

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Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth, Qi Li, Niraj K. Nirala, Yingchao Nie, Hsi-Ju Chen, Gary R. Ostroff, Junhao Mao, Qi Wang, Lan Xu, and Y. Tony Ip

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Dynamic Balance Measurement and Quantitative Assessment Using Wearable Plantar-Pressure Insoles in a Pose-Sensed Virtual Environment, Cunguang Lou, Chenyao Pang, Congrui Jing, Shuo Wang, Xufeng He, Xiaoguang Liu, Lei Huang, Feng Lin, Xiuling Liu, and Hongrui Wang

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Identification of Deubiquitinating Enzymes that Control the Cell Cycle in Saccharomyces cerevisiae, Claudine E. Mapa

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Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2, Jose Mercado-Matos, Jenny Janusis, Sha Zhu, Samuel S. Chen, and Leslie M. Shaw

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Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing, Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts, and Erik J. Sontheimer

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Heavily and Fully Modified RNAs Guide Efficient SpyCas9-Mediated Genome Editing, Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts, and Erik J. Sontheimer

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The NF-kappaB Factor Relish Regulates Atg1 Expression and Controls Autophagy, Anubhab Nandy, Lin Lin, Panagiotis D. Velentzas, Louisa P. Wu, Eric H. Baehrecke, and Neal S. Silverman

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ATACseqQC: a Bioconductor package for post-alignment quality assessment of ATAC-seq data, Jianhong Ou, Haibo Liu, Jun Yu, Michelle A. Kelliher, Lucio H. Castilla, Nathan D. Lawson, and Lihua Julie Zhu

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Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress, Min Peng, Ke Cong, Nicholas J. Panzarino, Sumeet Nayak, Jennifer Calvo, Bin Deng, Lihua Julie Zhu, Monika Morocz, Lili Hegedus, Lajos Haracska, and Sharon B. Cantor

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Mitochondrial Biogenesis: MitoCPR Resuscitates Import-Defective Mitochondria, Jacqueline Pires and Cole M. Haynes

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Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia, John A. Pulikkan and Lucio H. Castilla

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CBFbeta-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia, John A. Pulikkan, Mahesh Hegde, Hafiz Mohd Ahmad, Houda Belaghzal, Anuradha Illendula, Jun Yu, Kelsey O'Hagan, Jianhong Ou, Carsten Muller-Tidow, Scot A. Wolfe, Lihua J. Zhu, Job Dekker, John Hackett Bushweller, and Lucio H. Castilla (Cell, 2018-06-28)

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IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer, Sanjoy Samanta, Santosh Guru, Ameer L. Elaimy, John J. Amante, Jianhong Ou, Jun Yu, Lihua Julie Zhu, and Arthur M. Mercurio

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IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer, Sanjoy Samanta, Santosh Guru, Ameer L. Elaimy, John J. Amante, Jianhong Ou, Jun Yu, Lihua Julie Zhu, and Arthur M. Mercurio

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Impact of Concurrent Genomic Alterations Detected by Comprehensive Genomic Sequencing on Clinical Outcomes in East-Asian Patients with EGFR-Mutated Lung Adenocarcinoma, Seijiro Sato, Stephen Lyle, Toshifumi Wakai, and Masanori Tsuchida

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Metabolic shift from glycogen to trehalose promotes lifespan and healthspan in Caenorhabditis elegans, Yonghak Seo, Samuel F. Kingsley, Griffin Walker, Michelle A. Mondoux, and Heidi A. Tissenbaum

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Understanding and repurposing CRISPR-mediated alternative splicing, Jordan L. Smith, Haiwei Mou, and Wen Xue

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In vivo genome editing partially restores alpha1-antitrypsin in a murine model of AAT deficiency, Chun-Qing Song, Dan Wang, Tingting Jiang, Kevin O'Connor, Qiushi Tang, Lingling Cai, Xiangrui Li, Zhiping Weng, Hao Yin, Guangping Gao, Christian Mueller, Terence R. Flotte, and Wen Xue

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Emergence of the erythroid lineage from multipotent hematopoiesis, Betsabeh K. Tusi, Samuel L. Wolock, Caleb Weinreb, Yung Hwang, Daniel Hidalgo, Rapolas Zilionis, Ari Waisman, Jun R. Huh, Allon M. Klein, and Merav Socolovsky

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YAP drives cutaneous squamous cell carcinoma formation and progression, Zoe Vincent-Mistiaen, Ahmed Elbediwy, Hannah Vanyai, Jennifer L. Cotton, Gordon Stamp, Emma Nye, Bradley Spencer-Dene, Gareth J. Thomas, Junhao Mao, and Barry Thompson

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Deconvolution Of Subcellular Protrusion Heterogeneity And The Underlying Actin Regulator Dynamics From Live Cell Imaging, Chuangqi Wang, Hee June Choi, Sung-Jin Kim, Aesha Desai, Namgyu Lee, Dohoon Kim, Yongho Bae, and Kwonmoo Lee

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Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging, Chuangqi Wang, Hee June Choi, Sung-Jin Kim, Aesha Desai, Namgyu Lee, Dohoon Kim, Yongho Bae, and Kwonmoo Lee

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Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice, Dan Wang, Jia Li, Chun-Qing Song, Karen Tran, Haiwei Mou, Pei-Hsuan Wu, Phillip W. L. Tai L, Craig A. Mendonca, Lingzhi Ren, Blake Y. Wang, Qin Su, Dominic J. Gessler, Phillip D. Zamore, Wen Xue, and Guangping Gao

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The Dynamic Roles of Mesenchymal Stem Cells in Colon Cancer, Shan Wang, Zhiguo Miao, Qiyuan Yang, Yimin Wang, and Jinzhou Zhang

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Partial DNA-guided Cas9 enables genome editing with reduced off-target activity, Hao Yin, Chun-Qing Song, Sneha Suresh, Suet-Yan Kwan, Qiongqiong Wu, Stephen Walsh, Junmei Ding, Roman L. Bogorad, Lihua Julie Zhu, Scot A. Wolfe, Victor Koteliansky, Wen Xue, Robert Langer, and Daniel G. Anderson

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The Role of RIPK1 Kinase Activity in Regulating Inflammation and Necroptotic Death, Matija Zelic

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RIP kinase 1-dependent endothelial necroptosis underlies systemic inflammatory response syndrome, Matija Zelic, Justine E. Roderick, Joanne A. O'Donnell, Jesse Lehman, Sung Eun Lim, Harish P. Janardhan, Chinmay M. Trivedi, Manolis Pasparakis, and Michelle A. Kelliher

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The temporal landscape of recursive splicing during Pol II transcription elongation in human cells, Xiao-Ou Zhang, Yu Fu, Haiwei Mou, Wen Xue, and Zhiping Weng

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IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma, Sha Zhu, B. Marie Ward, Jun Yu, Asia N. Matthew-Onabanjo, Jenny Janusis, Chung-Cheng Hsieh, Keith Tomaszewicz, Lloyd Hutchinson, Lihua Julie Zhu, Dina Kandil, and Leslie M. Shaw

Publications from 2017

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Understanding Multiple Independent Functions of the Tip60 Acetyltransferase in Embryonic Development, Diwash Acharya

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Cleaning House: Selective Autophagy of Organelles, Allyson L. Anding and Eric H. Baehrecke