The Department of Molecular, Cell and Cancer Biology (MCCB) at the University of Massachusetts Medical School was established in 2015, and is the product of a merger between the Program in Gene Function and Expression and the Department of Cancer Biology. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Molecular, Cell and Cancer Biology. See earlier collections for selected Gene Function and Expression and Cancer Biology publications published before the departmental merger.

Follow


Publications from 2018

PDF

The Role of RIPK1 Kinase Activity in Regulating Inflammation and Necroptotic Death, Matija Zelic

Publications from 2017

PDF

Understanding Multiple Independent Functions of the Tip60 Acetyltransferase in Embryonic Development, Diwash Acharya

PDF

The alpha6beta4 integrin promotes resistance to ferroptosis, , John J. Amante, Hira Lal Goel, and Arthur M. Mercurio

Link

Cleaning House: Selective Autophagy of Organelles, and Eric H. Baehrecke

Link

Molecular definitions of autophagy and related processes, , Eric H. Baehrecke, and Guido Kroemer

PDF

Development of Chimeric Cas9 Nucleases for Accurate and Flexible Genome Editing, Mehmet F. Bolukbasi

PDF

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging, , Renee M. Brielmann, Mario F. Neto, Yi-Fan Lin, Cole M. Haynes, and Richard I. Morimoto

Link

Molecular Basis and Targeted Inhibition of CBFbeta-SMMHC Acute Myeloid Leukemia, and John H. Bushweller

PDF

Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells, , Jennifer L. Clark, Andrew J. Piper, Jenny Janusis, and Leslie M. Shaw

PDF

A synthetic biology approach to probing nucleosome symmetry, , Caitlin M. Connolly, Hsin-Jung Chou, Yuanyuan Chen, Upasna Sharma, Hsuiyi V. Chen, Vineeta Bajaj, Daniel Na. Bolon, Oliver J. Rando, and Paul D. Kaufman

PDF

Regulation of Pluripotency and Differentiation by Chromatin Remodeling Factors, Ly-Sha Ee

PDF

Clinical application of a cancer genomic profiling assay to guide precision medicine decisions, Cheryl Eifert, Angeliki Pantazi, Ruobai Sun, Jia Xu, Pablo Cingolani, Joerg Heyer, Meaghan Russell, Maria Lvova, Jennifer Ring, Julie Y. Tse, Stephen Lyle, and Alexei Protopopov

PDF

Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease, Caitlin E. Fogarty and Andreas Bergmann

Link

Integrating the UPRmt into the mitochondrial maintenance network, and Cole M. Haynes

Link

Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR, and Cole M. Haynes

Link

Mitochondrial Sterol Oxidation Marks the Spot, and Cole M. Haynes

Link

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing, and Cole M. Haynes

PDF

The mitochondrial unfolded protein response: Signaling from the powerhouse, , Cole M. Haynes, and Mark W. Pellegrino

PDF

Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation, Lei Huang, Dongning Pan, Qingbo Chen, Lihua (Julie) Zhu, Jianhong Ou, Martin Wabitsch, and Yong-Xu Wang

PDF

Global increase in replication fork speed during a p57KIP2-regulated erythroid cell fate switch, Yung Hwang, Melinda Futran, Daniel Hidalgo, Ramona Pop, Divya Ramalingam Iyer, Ralph Scully, Nicholas R. Rhind, and Merav Socolovsky

Link

RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia, , Anuradha Illendula, John A. Pulikkan, Justine E. Roderick, Jessica M. Tesell, Jun Yu, Nicole M. Hermance, Lihua (Julie) Zhu, Lucio H. Castilla, John H. Bushweller, and Michelle A. Kelliher

PDF

Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1alpha, Hoe-Yune Jung, Namgyu Lee, and Kyong-Tai Kim

PDF

Regulation of the Drosophila Initiator Caspase Dronc through Ubiquitylation, Hatem E. Kamber Kaya

PDF

An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways, Hatem E. Kamber Kaya, Mark Ditzel, Pascal Meier, and Andreas Bergmann

Link

RIPK1 mediates a disease-associated microglial response in Alzheimer's disease, , Michelle A. Kelliher, and Junying Yuan

PDF

The Dkk3 gene encodes a vital intracellular regulator of cell proliferation, Jack L. Leonard, Deborah Marie Leonard, Scot A. Wolfe, Jilin Liu, Jaime A. Rivera-Perez, Michelle Yang, Ryan T. Leonard, Jacob P. S. Johnson, Prashant Kumar, Kate L. Liebmann, Amanda A. Tutto, Zhongming Mou, and Karl J. Simin

PDF

CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells, , Dun Li, Yun Zhou, Esther Landesman-Bollag, Guanglan Zhang, Nicole M. Anderson, Kevin Charles. Tang, Justine E. Roderick, Michelle A. Kelliher, David C. Seldin, Hui Fu, and Hui Feng

PDF

Complement-Related Regulates Autophagy in Neighboring Cells, Lin Lin

Link

CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy, Leyuan Ma, Jeffrey I. Boucher, Janet L. Paulsen, Sebastian Matuszewski, Christopher A. Eide, Jianhong Ou, Garrett Eickelberg, Richard D. Press, Lihua (Julie) Zhu, Brian J. Druker, Susan Branford, Scot A. Wolfe, Jeffrey D. Jensen, Celia A. Schiffer, Michael R. Green, and Daniel N. Bolon

PDF

CAF-1 p150 and Ki-67 Regulate Nuclear Structure Throughout the Human Cell Cycle, Timothy D. Matheson

PDF

The p150N domain of chromatin assembly factor-1 regulates Ki-67 accumulation on the mitotic perichromosomal layer, Timothy D. Matheson and Paul D. Kaufman

PDF

RUNX1 and breast cancer, , Asia N. Matthew-Onabanjo, and Leslie M. Shaw

PDF

Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia, Kate McArthur, Akshay A. D'Cruz, David Segal, Kurt Lackovic, Andrew F. Wilks, Joanne A. O'Donnell, Cameron J. Nowell, Motti Gerlic, David C. S. Huang, Christopher J. Burns, and Ben A. Croker

PDF

A Mechanistic Investigation of Insulin Receptor Substrate 2 Function in Breast Cancer Progression, Jose R. Mercado-Matos

PDF

JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias, , L. K. Meyer, B. J. Huang, M. S. Zinter, J. V. Nguyen, G. A. Smith, J. Taunton, S. S. Winter, Justine R. Roderick, Michelle A. Kelliher, T. M. Horton, B. L. Wood, D. T. Teachey, and M. L. Hermiston

PDF

Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis, Haiwei Mou, Jill Moore, Sunil K. Malonia, Yingxiang Li, Deniz M. Ozata, Soren Hough, Chun-Qing Song, Jordan L. Smith, Andrew H. Fischer, Zhiping Weng, Michael R. Green, and Wen Xue

PDF

CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion, Haiwei Mou, Jordan L. Smith, Lingtao Peng, Jill Moore, Xiao-Ou Zhang, Chun-Qing Song, Ankur Sheel, Deniz M. Ozata, Yingxiang Li, Charles P. Emerson Jr., Erik J. Sontheimer, Melissa J. Moore, Zhiping Weng, and Wen Xue

PDF

Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila, Ernesto Perez, Jillian L. Lindblad, and Andreas Bergmann

PDF

MicroRNAs of the mir-17~92 cluster regulate multiple aspects of pancreatic tumor development and progression, Brian J. Quattrochi, Anushree Gulvady, David R. Driscoll, Makoto Sano, David S. Klimstra, Christopher E. Turner, and Brian C. Lewis

Link

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment, , Justine E. Roderick, Michelle A. Kelliher, and James E. Bradner

Link

Complement-Related Regulates Autophagy in Neighboring Cells, , Frederico S. L. M. Rodrigues, Christina Kary, Alicia Contet, Mary Logan, Richard H. Baxter G, Will Wood, and Eric H. Baehrecke

PDF

Comprehensive genomic sequencing detects important genetic differences between right-sided and left-sided colorectal cancer, Yoshifumi Shimada, Stephen Lyle, Kazuaki Takabe, and Toshifumi Wakai

PDF

Utility of comprehensive genomic sequencing for detecting HER2-positive colorectal cancer, Yoshifumi Shimada, Stephen Lyle, and Toshifumi Wakai

Link

Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice, Chun-Qing Song, Yingxiang Li, Haiwei Mou, Jill Moore, Angela I. Park, Soren Hough, Zachary Kennedy, Andrew H. Fischer, Darryl Conte Jr., Zhiping Weng, and Wen Xue

PDF

Ki-67 Regulates Cell Cycle Progression and Heterochromatin Organization, Xiaoming Sun

PDF

Critical role for arginase 2 in obesity-associated pancreatic cancer, , Pei-Yun Tsai, Daniel S. Hitchcock, Cory D. DuBois, Elizaveta Freinkman, Lin Lin, Vicente Morales-Oyarvide, Patrick J. Lenehan, Brian M. Wolpin, Mari Mino-Kenudson, Eduardo M. Torres, Nicholas Stylopoulos, Clary B. Clish, and Nada Y. Kalaany

PDF

(CCUG)n RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis, Vildan Betul Yenigun, Mario Sirito, Alla Amcheslavsky, Tomek Czernuszewicz, Jordi Colonques-Bellmunt, Irma Garcia-Alcover, Marzena Wojciechowska, Clare Bolduc, Zhihong Chen, Arturo Lopez Castel, Ralf Krahe, and Andreas Bergmann

PDF

GUIDEseq: a bioconductor package to analyze GUIDE-Seq datasets for CRISPR-Cas nucleases, Lihua Julie Zhu, Michael Lawrence, Ankit Gupta, Herve Pages, Alper Kucukural, Manuel Garber, and Scot A. Wolfe

Publications from 2016

PDF

Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer, Marc A. Becker, Yasir H. Ibrahim, Annabell S. Oh, Dedra H. Fagan, Sara A. Byron, Aaron L. Sarver, Adrian V. Lee, Leslie M. Shaw, Cheng Fan, Charles M. Perou, and Douglas Yee

PDF

Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis, Michael I. Carr, Justine E. Roderick, Hugh S. Gannon, Michelle A. Kelliher, and Stephen N. Jones (Cell reports)

PDF

Requirement and Function of Hippo Pathway Signaling in the Mammalian Gastrointestinal Tract: A Dissertation, Jennifer L. Cotton

PDF

The beneficial role of extracellular reactive oxygen species in apoptosis-induced compensatory proliferation, Neha Diwanji and Andreas Bergmann

PDF

Levels of YCG1 Limit Condensin Function during the Cell Cycle: A Dissertation, Tyler W. Doughty

PDF

Levels of Ycg1 Limit Condensin Function during the Cell Cycle, Tyler W. Doughty, Heather E. Arsenault, and Jennifer A. Benanti

PDF

The Impact of mTORC2 Signaling on the Initiation and Progression of KRAS-Driven Pancreatic Neoplasias: A Dissertation, David R. Driscoll

PDF

Investigation of RNA Binding Protein Pumilio as a Genetic Modifier of Mutant CHMP2B in Frontotemporal Dementia (FTD): A Masters Thesis, Xing Du

Link

Extracellular Reactive Oxygen Species Drive Apoptosis-Induced Proliferation via Drosophila Macrophages, Caitlin E. Fogarty, Neha Diwanji, Jillian L. Lindblad, Meghana Tare, Alla Amcheslavsky, Kalpana Makhijani, Katja Bruckner, Yun Fan, and Andreas Bergmann

PDF

P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer, Hira Lal Goel, Bryan M. Pursell, Leonard D. Shultz, Dale L. Greiner, Rolf A. Brekken, Craig W. Vander Kooi, and Arthur M. Mercurio

PDF

RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes, , Esteban Nicolas Grasso, Pablo Christian Echeverria, Luciana Rocha-Viegas, Lucio H. Castilla, Carolina Schere-Levy, Johanna Melisa Tocci, Edith Claudia Kordon, and Natalia Rubinstein

PDF

Septate Junction Proteins Play Essential Roles in Morphogenesis Throughout Embryonic Development in Drosophila, Sonia Hall and Robert E. Ward 4th

Link

The mitokine quest(ion), and Cole M. Haynes

PDF

Small Molecule Inhibitor of CBFbeta-RUNX Binding for RUNX Transcription Factor Driven Cancers, Anuradha Illendula, John A. Pulikkan, Lucio H. Castilla, and John H. Bushweller

Link

The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis, , Michelle A. Kelliher, and H. Feng

Link

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice, , Michelle A. Kelliher, Justine E. Roderick, and David M. Weinstock

Link

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS, , Michelle A. Kelliher, and Junying Yuan

PDF

Cancer Metabolism: Fueling More than Just Growth, and Dohoon Kim

Link

The initiator caspase Dronc is subject of enhanced autophagy upon proteasome impairment in Drosophila, T. V. Lee, H. E. Kamber Kaya, Rachel T. Simin, Eric H. Baehrecke, and Andreas Bergmann

PDF

CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN, Diana Legarda, Scott J. Justus, Rosalind L. Ang, Nimisha Rikhi, Wenjing Li, Thomas M. Moran, Jianke Zhang, Emiko Mizoguchi, Matija Zelic, Michelle A. Kelliher, J. Magarian Blander, and Adrian T. Ting

PDF

Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation, Mingli Li, Jillian L. Lindblad, Ernesto Perez, Andreas Bergmann, and Yun Fan

PDF

Tead and AP1 Coordinate Transcription and Motility, Xiangfan Liu, Huapeng Li, Mihir S. Rajurkar, Qi Li, Jennifer L. Cotton, Jianhong Ou, Lihua J. Zhu, Hira L. Goel, Arthur M. Mercurio, Joo-Seop Park, Roger J. Davis, and Junhao Mao

PDF

Radial glia regulate vascular patterning around the developing spinal cord, Ryota L. Matsuoka, Michele Marass, Avdesh Avdesh, Christian S.M. Helker, Hans-Martin Maischein, Ann S. Grosse, Harmandeep Kaur, Nathan D. Lawson, Wiebke Herzog, and Didier Y.R. Stainier

PDF

Genomic landscape of colorectal cancer in Japan: clinical implications of comprehensive genomic sequencing for precision medicine, Masayuki Nagahashi, Toshifumi Wakai, and Stephen R. Lyle

PDF

Clinical expression of facioscapulohumeral muscular dystrophy in carriers of 1-3 D4Z4 reduced alleles: experience of the FSHD Italian National Registry, Ana Nikolic and Rossella Tupler

Link

Prenatal Maternal Physical Activity and Stem Cells in Umbilical Cord Blood, Sagano Onoyama, Linghua Qiu, Hoi Pang Low, Chien-I Chang, William C. Strohsnitter, Errol R. Norwitz, Mary Lopresti, Kathryn Edmiston, I-Min Lee, Dimitrios Trichopoulos, Pagona Lagiou, and Chung-Cheng Hsieh

PDF

The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles, Mariam H. Orme, Meghana Tare, Andreas Bergmann, and Pascal Meier

PDF

The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles, Mariam H. Orme, Meghana Tare, Andreas Bergmann, and Pascal Meier

PDF

The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L, Victoria E. Pedanou, Stephane Gobeil, Sebastien Tabaries, Tessa M. Simone, Lihua Julie Zhu, Peter M. Siegel, and Michael R. Green

PDF

A novel clinical tool to classify facioscapulohumeral muscular dystrophy phenotypes, Giulia Ricci and Rossella Ginevra Tupler

Link

High-Throughput Screening of Tyrosine Kinase Inhibitor Resistant Genes in CML, , Justine E. Roderick, Michelle A. Kelliher, and Michael R. Green

PDF

Activation of WNT/beta-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61, Makoto Sano, David R. Driscoll, Wilfredo E. De Jesus-Monge, Brian J. Quattrochi, Victoria A. Appleman, Jianhong Ou, Lihua (Julie) Zhu, and Brian C. Lewis

Link

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR, , Anna M. Schulz, Yi-Fan Lin, Nadine Rosin, Mark W. Pellegrino, and Cole M. Haynes

Link

Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity, , Yonghak Seo, Daniel W. Bak, Samuel F. Kingsley, Heidi A. Tissenbaum, and Eranthie Weerapana

Link

An autophagy-independent function for Beclin 1 in cancer, and Leslie M. Shaw

PDF

No current evidence for widespread dosage compensation in S. cerevisiae, , Michael Springer, and Angelika Amon

PDF

Function of the β4 Integrin in Cancer Stem Cells and Tumor Formation in Breast Cancer: A Masters Thesis, Huayan Sun

PDF

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-kappaB-Dependent and -Independent Functions, Katerina Vlantis, Andy Wullaert, Apostolos Polykratis, Vangelis Kondylis, Marius Dannappel, Robin Schwarzer, Patrick Welz, Teresa Corona, Henning Walczak, Falk Weih, Ulf Klein, Michelle Kelliher, and Manolis Pasparakis

Link

Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila, Y. Wu, Jillian L. Lindblad, J. Garnett, H. E. Kamber Kaya, D. Xu, Y. Zhao, E. R. Flores, J. Hardy, and Andreas Bergmann

Link

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo, Hao Yin, Chun-Qing Song, Joseph R. Dorkin, Lihua Julie Zhu, Yingxiang Li, Qiongqiong Wu, Angela I. Park, Junghoon Yang, Sneha Suresh, Aizhan Bizhanova, Ankit Gupta, Mehmet Fatih Bolukbasi, Stephen Walsh, Roman L. Bogorad, Guangping Gao, Zhiping Weng, Yizhou Dong, Victor Koteliansky, Scot A. Wolfe, Robert Langer, Wen Xue, and Daniel G. Anderson

Link

Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine, Tatsuyuki Yoshii, Yingying Geng, Shelly Peyton, Arthur M. Mercurio, and Vincent M. Rotello

Publications from 2015

PDF

The p53R172H Mutant Does Not Enhance Hepatocellular Carcinoma Development and Progression, Leanne G. Ahronian, David R. Driscoll, David S. Klimstra, and Brian C. Lewis

Link

Autophagy in Cell Life and Cell Death, Allyson L. Anding and Eric H. Baehrecke

PDF

Hcm1 integrates signals from Cdk1 and calcineurin to control cell proliferation, Heather E. Arsenault, Jagoree Roy, Claudine E. Mapa, Martha S. Cyert, and Jennifer A. Benanti

PDF

Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants, Ankita Bansal, Lihua Julie Zhu, Kelvin Yen, and Heidi A. Tissenbaum

Link

Create, activate, destroy, repeat: Cdk1 controls proliferation by limiting transcription factor activity, Jennifer A. Benanti

Link

TRIMming down tumor suppressors in breast cancer, Sanchita Bhatnagar and Michael R. Green

PDF

Integrating motif, DNA accessibility and gene expression data to build regulatory maps in an organism, Charles Blatti, Majid Kazemian, Scot A. Wolfe, Michael H. Brodsky, and Saurabh Sinha

Link

DNA-binding-domain fusions enhance the targeting range and precision of Cas9, Mehmet Fatih Bolukbasi, Ankit Gupta, Sarah Oikemus, Alan G. Derr, Manuel Garber, Michael H. Brodsky, Lihua Julie Zhu, and Scot A. Wolfe

Link

Runx1 is associated with breast cancer progression in MMTV-PyMT transgenic mice and its depletion in vitro inhibits migration and invasion, Gillian Browne, Hanna Taipaleenmaki, Nicole M. Bishop, Sharath C. Madasu, Leslie M. Shaw, Andre J. van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian

Link

Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo, Emerald Butko, Martin Distel, Claire Pouget, Bart Weijts, Isao Kobayashi, Kevin Ng, Christian Mosimann, Fabienne E. Poulain, Adam McPherson, Chih-Wen Ni, David L. Stachura, Natasha Del Cid, Raquel Espin-Palazon, Nathan D. Lawson, Richard Dorsky, Wilson K. Clements, and David Traver

PDF

Function and Regulation of the α6 Integrins in Mammary Epithelial Biology and Breast Cancer: A Dissertation, Cheng Chang