The Department of Microbiology and Physiological Systems (MaPS) was founded in 2010, and is the product of a merger between two departments, one focused on microbiology, genetics, and immunology, and the other focused on physiology. Capitalizing on the strength of the respective scientific research programs, the resulting department has strong and synergistic expertise in bacterial and viral pathogenesis, immunology, signal transduction, and fundamental cellular physiology. Current departmental research targets include viral and bacterial pathogens affecting the nervous, respiratory, and digestive systems. The mission of the new department is to address important biological questions broadly relevant to infectious disease and encompassing multiple levels of biological organization, including an understanding of pathogen effects on their target organ systems. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Microbiology and Physiological Systems. See earlier collections for selected Physiology and Molecular Genetics and Microbiology publications published before the departmental merger.

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Publications from 2008

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Molecular Mechanisms of Neuropeptide Secretion from Neurohypophysial Terminals: a Dissertation, James M. McNally

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Modulation of Voltage-Gated N-Type Calcium Channels by G Protein-Coupled Receptors Involves Lipids and Proteins: A Dissertation, Tora Mitra Ganguli

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Modulation of Neuropeptide Release via Voltage-Dependent and -Independent Signaling in Isolated Neurohypophysial Terminals: a Dissertation, Cristina M. Velazquez-Marrero

Publications from 2007

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Collagen and Fibrin Bioplymer Microthreads for Bioengineered Ligament Generation: a Dissertation, Kevin Cornwell

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Transcript-Specific Cytoplasmic Degradation of YRA1 Pre-mRNA Mediated by the Yeast EDC3 Protein: A Dissertation, Shuyun Dong

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Data from: PTC124 Targets Genetic Disorders Caused by Nonsense Mutations, Allan Jacobson, Phyllis Spatrick, and Feng He

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Surface of Yersinia pestis: LCRV, F1 Production, Invasion and Oxygen: A Dissertation, Kimberly Lea Pouliot

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Modulation of Cav1.3 L-Type Calcium Channels by Arachidonic Acid and Muscarinic M1 Receptors: A Dissertation, Mandy L. Roberts-Crowley

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Interaction of a Mammalian Virus with Host RNA Silencing Pathways: A Dissertation, Bradford Michael Stadler

Publications from 2006

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Intracellular accumulation of a 46 kDa species of mouse prion protein as a result of loss of glycosylation in cultured mammalian cells, Subhabrata Biswas, Jan P.M. Langeveld, Donald J. Tipper, and Shan Lu

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Characterization of the Relationship Between Measles Virus Fusion, Receptor Binding, and the Virus-Specific Interaction Between the Hemagglutinin and Fusion Glycoproteins: a Dissertation, Elizabeth Ann Corey

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Requirements for Assembly and Release of Newcastle Disease Virus-Like Particles: A Dissertation, Homer Dadios Pantua

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Rb Inactivation Leads to E2F1-mediated DNA Double Strand Break Accumulation: A Dissertation, Mary Theresa Pickering

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Regulation of Contractility by Adenosine A1 and A2A Receptors in the Murine Heart: Role of Protein Phosphatase 2A: A Dissertation, Eugene I. Tikh

Publications from 2005

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Characterization of the Interaction Between the Attachment and Fusion Glycoproteins Required for Paramyxovirus Fusion: a Dissertation, Vanessa R. Melanson

Publications from 2004

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Prevention of Oxidative Damage by Yeast and Human OXR1: A Dissertation, Nathan Andrew Elliott

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Pathways Linking Deregulated Proliferation to Apoptosis: a Dissertation, Harry A. Rogoff

Publications from 2002

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A Characterization of Substrates and Factors Involved in Yeast Nonsense-Mediated mRNA Decay: A Dissertation, Jonathan Philip Belk

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Kre1p, the plasma membrane receptor for the yeast K1 viral toxin, Frank Breinig, Donald J. Tipper, and Manfred J. Schmitt

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The Role of Human Cytomegalovirus Immediate Early Proteins in Cell Growth Control: A Dissertation, Jonathan Patrick Castillo

Publications from 2001

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Modulation of N-type Calcium Channels in Rat Superior Cervical Ganglion Neurons: A Dissertation, Curtis F. Barrett

Publications from 2000

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CIS/SOCS Proteins in Growth Hormone Action: A Dissertation, Ling Du

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A Study on the Cellular Localization of Factors Involved in Yeast Nonsense-Mediated mRNA Decay and their Mechanisms of Control on Nonsense mRNA Translation: a Dissertation, Alan Baer Maderazo

Publications from 1999

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A novel membrane protein influencing cell shape and multicellular swarming of Proteus mirabilis, Nicole A. Hay, Donald J. Tipper, Daniel Gygi, and Colin Hughes

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mRNA Poly(A) tail: a 3' Enhancer of Translational Initiation: a Thesis, David Munroe

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Mechanisms of Newcastle Disease Virus-Mediated Membrane Fusion: A Dissertation, Judith Stone-Hulslander

Publications from 1998

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Transmembrane protein insertion orientation in yeast depends on the charge difference across transmembrane segments, their total hydrophobicity, and its distribution, Carol A. Harley, Jonathan A. Holt, Rhiannon Turner, and Donald J. Tipper

Publications from 1997

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A nonswarming mutant of Proteus mirabilis lacks the Lrp global transcriptional regulator, Nicole A. Hay, Donald J. Tipper, Daniel Gygi, and Colin Hughes

Publications from 1996

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Cell cycle studies on the mode of action of yeast K28 killer toxin, Manfred J. Schmitt, Petra Klavehn, Jing Wang, Inge Schonig, and Donald J. Tipper

Publications from 1995

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Sequence of the M28 dsRNA: preprotoxin is processed to an alpha/beta heterodimeric protein toxin, Manfred J. Schmitt and Donald J. Tipper

Publications from 1994

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Use of beta-lactamase as a secreted reporter of promoter function in yeast, Charles P. Cartwright, Yu Li, Yun Song Zhu, Yoon Se Kang, and Donald J. Tipper

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Analysis of Temperature Sensing in Yersinia pestis: A Dissertation, Nancy Palme Hoe

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Transcriptional Regulation by the SACCHAROMYCES CEREVISIAE Centromere-Binding Protein CP1: a Dissertation, Kevin F. O'Connell

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A Mutational Analysis of Structural Determinants Within the Newcastle Disease Virus Fusion Protein: a Dissertation, Julie N. Reitter

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Signal Transduction Mechanisms for the Stimulation of Lipolysis by Growth Hormone: A Dissertation, Rupert G. Yip

Publications from 1993

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Genetic Analysis of the Saccharomyces Cerevisiae Centromere-Binding Protein CP1: a Thesis, Daniel C. Masison

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Regulation of IgA Class Switch Recombination in the I.29μ B Cell Lymphoma by Cytokines and Inhibitors of Poly(ADP-ribose) Polymerase: A Thesis, Penny E. Shockett

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Suppression of a dominant G-protein beta-subunit mutation in yeast by G alpha protein expression, Meng Zhang and Donald J. Tipper

Publications from 1992

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Kex2-dependent processing of yeast K1 killer preprotoxin includes cleavage at ProArg-44, Yun Song Zhu, Xia Ying Zhang, Charles P. Cartwright, and Donald J. Tipper

Publications from 1991

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Virus-Lymphocyte Interactions: Virus Expression Is Differentially Modulated by B Cell Activation Signals: A Dissertation, Madelyn R. Schmidt

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Yeast dsRNA viruses: replication and killer phenotypes, Donald J. Tipper and Manfred J. Schmitt

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Regulation of Transcription of Mouse Immunoglobulin Germ-Line γ1 RNA: Structural Characterization of Germ-Line γ1 RNA and Molecular Analysis of the Promoter: A Dissertation, Minzhen Xu

Publications from 1990

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Regulation of β-Adrenergic-Induced Protein Phosphorylation in the Myocardium: A Dissertation, Edward E. George

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The Stimulation of Luteinizing Hormone Secretion from Anterior Pituitary Cells in Culture by Substance P: A Dissertation, Maureen Shamgochian

Publications from 1989

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Structural Determinants of mRNA Turnover in Yeast: a Thesis, David Herrick

Publications from 1987

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The major acid-soluble proteins of Bacillus subtilis spores: partial amino acid sequence and forespore location of their mRNAs, Hans Blom, Robert Morse, J. Mandelkorn, M. Arnaud, R. Warburg, and Donald J. Tipper

Publications from 1986

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Expression of a cDNA derived from the yeast killer preprotoxin gene: implications for processing and immunity, Steven D. Hanes, Virginia E. Burn, Stephen L. Sturley, Donald J. Tipper, and Kieth A. Bostian

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Mapping of functional domains within the Saccharomyces cerevisiae type 1 killer preprotoxin, Stephen L. Sturley, Quentin Elliot, JoAnn LeVitre, Donald J. Tipper, and Keith A. Bostian

Publications from 1985

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Transcriptional control of synthesis of acid-soluble proteins in sporulating Bacillus subtilis, W. Charles Johnson, Inga Mahler, Kent Phillips, and Donald J. Tipper

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Mode of action of beta-lactam antibiotics, Donald J. Tipper

Publications from 1984

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Sequence of the preprotoxin dsRNA gene of type I killer yeast: multiple processing events produce a two-component toxin, Keith A. Bostian, Quentin Elliott, Howard Bussey, Virginia Burn, Al Smith, and Donald J. Tipper

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Virus-like particle capsid proteins encoded by different L double-stranded RNAs of Saccharomyces cerevisiae: their roles in maintenance of M double-stranded killer plasmids, Mohamed El-Sherbeini, Donald J. Tipper, Diane J. Mitchell, and Keith A. Bostian

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Cloning of an unstable spoIIA-tyrA fragment from Bacillus subtilis, Inga Mahler, R. Warburg, Donald J. Tipper, and H. O. Halvorson

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Double-stranded ribonucleic acid killer systems in yeasts, Donald J. Tipper and Kieth A. Bostian

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Cloning the Bacillus subtilis 168 aroC gene encoding dehydroquinase, R. J. Warburg, Inga Mahler, Donald J. Tipper, and H. O. Halvorson

Publications from 1983

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Yeast killer dsRNA plasmids are transcribed in vivo to produce full and partial-length plus-stranded RNAs, Keith A. Bostian, Virginia E. Burn, S. Jayachandran, and Donald J. Tipper

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A glycosylated protoxin in killer yeast: models for its structure and maturation, Keith A. Bostian, S. Jayachandran, and Donald J. Tipper

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Secretion of Saccharomyces cerevisiae killer toxin: processing of the glycosylated precursor, H. Bussey, D. Saville, D. Greene, Donald J. Tipper, and Keith A. Bostian

Publications from 1981

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Coat protein synthesis during sporulation of Bacillus subtilis: immunological detection of soluble precursors to the 12,200-dalton spore coat protein, Robert C. Goldman and Donald J. Tipper

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Acid-soluble spore proteins of Bacillus subtilis, W. C. Johnson and Donald J. Tipper

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Comparison of various properties of low-molecular-weight proteins from dormant spores of several Bacillus species, Katherine Yuan, W. Charles Johnson, Donald J. Tipper, and Peter Setlow

Publications from 1980

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Translational analysis of the killer-associated virus-like particle dsRNA genome of S. cerevisiae: M dsRNA encodes toxin, Keith A. Bostian, James E. Hopper, Davis T. Rogers, and Donald J. Tipper

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Encapsidation of yeast killer double-stranded ribonucleic acids: dependence of M on L, Keith A. Bostian, Joyce A. Sturgeon, and Donald J. Tipper

Publications from 1979

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Morphology and patterns of protein synthesis during sporulation of Bacillus subtilis Eryr spo(Ts) mutants, Robert C. Goldman and Donald J. Tipper

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Location of peptidoglycan lytic enzymes in Bacillus sphaericus, M. Guinand, M. J. Vacheron, G. Michel, and Donald J. Tipper

Publications from 1978

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Bacillus subtilis spore coats: complexity and purification of a unique polypeptide component, Robert C. Goldman and Donald J. Tipper

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Morphology of an Escherichia coli mutant with a temperature-dependent round cell shape, Makoto Iwaya, Robert Goldman, Donald J. Tipper, B. Feingold, and Jack L. Strominger

Publications from 1977

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Translation of the L-species dsRNA genome of the killer-associated virus-like particles of Saccharomyces cerevisiae, James E. Hopper, Keith A. Bostian, Lucy B. Rowe, and Donald J. Tipper

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Erythromycin resistant mutations in Bacillus subtilis cause temperature sensitive sporulation, Donald J. Tipper, C. W. Johnson, C. L. Ginther, T. Leighton, and H. G. Wittmann

Publications from 1976

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Transcriptional control of peptidoglycan precursor synthesis during sporulation in Bacillus sphaericus, Paul E. Linnett and Donald J. Tipper

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Distribution of peptidoglycan synthetase activities between sporangia and forespores in sporulating cells of Bacillus sphaericus, Donald J. Tipper and Paul E. Linnett

Publications from 1975

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Ultrastructural studies of sporulation in Bacillus sphaericus, Stanley C. Holt, J. J. Gauther, and Donald J. Tipper

Publications from 1974

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Appearance of gamma-D-glutamyl-(L) meso-diaminopimealate peptidoglycan hydrolase during sporulation in Bacillus sphaericus, M. Guinand, G. Michel, and Donald J. Tipper

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Inhibition of messenger ribonucleic acid synthesis in Escherichia coli by thiolutin, G. G. Khachatourians and Donald J. Tipper

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In vivo effect of thiolutin on cell growth and macromolecular synthesis in Escherichia coli, G. G. Khachatourians and Donald J. Tipper

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Cell wall polymers of Bacillus sphaericus: activities of enzymes involved in peptidoglycan precursor synthesis during sporulation, Paul E. Linnett and Donald J. Tipper

Publications from 1973

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A polypeptide bacteriophage receptor: modified cell wall protein subunits in bacteriophage-resistant mutants of Bacillus sphaericus strain P-1, Lawrence Howard and Donald J. Tipper

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Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae, A. Jimenez, Donald J. Tipper, and J. Davies

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Inhibition of yeast ribonucleic acid polymerases by thiolutin, Donald J. Tipper

Publications from 1972

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Conditional mutants of Staphylococcus aureus defective in cell wall precursor synthesis, C. M. Good and Donald J. Tipper

Publications from 1971

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Isolation and characterization of -1,4-N-acetylmuramyl-N-acetylglucosamine and its O-acetyl derivative, Donald J. Tipper, M. Tomoeda, and Jack L. Strominger