The Department of Microbiology and Physiological Systems (MaPS) was founded in 2010, and is the product of a merger between two departments, one focused on microbiology, genetics, and immunology, and the other focused on physiology. Capitalizing on the strength of the respective scientific research programs, the resulting department has strong and synergistic expertise in bacterial and viral pathogenesis, immunology, signal transduction, and fundamental cellular physiology. Current departmental research targets include viral and bacterial pathogens affecting the nervous, respiratory, and digestive systems. The mission of the new department is to address important biological questions broadly relevant to infectious disease and encompassing multiple levels of biological organization, including an understanding of pathogen effects on their target organ systems. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Microbiology and Physiological Systems. See earlier collections for selected Physiology and Molecular Genetics and Microbiology publications published before the departmental merger.

Follow


Publications from 2012

Link

Disruption of IFT Complex A Causes Cystic Kidneys without Mitotic Spindle Misorientation, Julie A. Jonassen, Jovenal T. San Agustin, Stephen P. Baker, and Gregory J. Pazour

PDF

Allele- and tir-independent functions of intimin in diverse animal infection models, Emily M. Mallick, Michael J. Brady, Steven A. Luperchio, Vijay K. Vanguri, Loranne Magoun, Hui Liu, Barbara J. Sheppard, Jean Mukherjee, Arthur Donohue-Rolfe, Saul Tzipori, John M. Leong, and David B. Schauer

PDF

A novel murine infection model for Shiga toxin-producing Escherichia coli, Emily M. Mallick, Megan E. McBee, Vijay K. Vanguri, Angela R. Melton-Celsa, Katherine Schlieper, Brad J. Karalius, Alison D. O’Brien, Joan R. Butterton, John M. Leong, and David B. Schauer

Link

Production and discovery of novel recombinant adeno-associated viral vectors, Christian Mueller, Li Zhong, Dmitry Ratner, Miguel Sena-Esteves, and Guangping Gao

PDF

Structural/functional analysis of the human OXR1 protein: identification of exon 8 as the anti-oxidant encoding function, Kenan C. Murphy and Michael R. Volkert

Link

Rabenosyn-5 Defines the Fate of the Transferrin Receptor Following Clathrin-mediated Endocytosis, Deanna M. Navaroli, Karl D. Bellve, Clive Standley, Lawrence M. Lifshitz, James Cardia, David Lambright, Deborah Leonard, Kevin E. Fogarty, and Silvia Corvera

Link

Smurf2 regulates the senescence response and suppresses tumorigenesis in mice, Charusheila Ramkumar, Yahui Kong, Hang Cui, Suyang Hao, Stephen N. Jones, Rachel M. Gerstein, and Hong Zhang (Cancer research)

PDF

The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells, Anna J. Ucher, Erin K. Linehan, George W. Teebor, Carol E. Schrader, and Janet Stavnezer

Link

Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility, Margaretha Van der Deen, Jacqueline Akech, David S. Lapointe, Sneha Gupta, Daniel W. Young, Martin A. Montecino, Mario Galindo, Jane B. Lian, Janet L. Stein, Gary S. Stein, and Andre J. Van Wijnen (The Journal of biological chemistry)

PDF

Host-pathogen interactions of retroviruses, Abdul A. Waheed, Abraham L. Brass, Suryaram Gummuluru, and Gilda Tachedjian

Link

Long-term, efficient inhibition of microRNA function in mice using rAAV vectors, Jun Xie, Stefan L. Ameres, Randall H. Friedline, Jui-Hung Hung, Yu Zhang, Qing Xie, Li Zhong, Qin Su, Ran He, Mengxin Li, Huapeng Li, Xin Mu, Hongwei Zhang, Jennifer A. Broderick, Jason K. Kim, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao

Publications from 2011

PDF

Metabolic regulation of mycobacterial growth and antibiotic sensitivity, Seung-Hun Baek, Alice H. Li, and Christopher M. Sassetti

Link

Cyclin-specific docking motifs promote phosphorylation of yeast signaling proteins by G1/S Cdk complexes., Samyabrata Bhaduri and Peter M. Pryciak

PDF

An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus, Xiaofei E., Mary Theresa Pickering, Michelle E. Debatis, Jonathan Patrick Castillo, Alexander Lagadinos, Shixia Wang, Shan Lu, and Timothy F. Kowalik

PDF

A Global Analysis of the Adaptations Required for Sterol Catabolism in Mycobacterium Tuberculosis: A Dissertation, Jennifer E. Griffin

PDF

High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism, Jennifer E. Griffin, Jeffrey D. Gawronski, Michael A. Dejesus, Thomas R. Ioerger, Brian J. Akerley, and Christopher M. Sassetti

PDF

Crosstalk between NDR kinase pathways coordinates cell cycle dependent actin rearrangements, Sneha Gupta and Dannel McCollum

PDF

Calpain mediates epithelial cell microvillar effacement by enterohemorrhagic Escherichia coli, YuShuan (Cindy) Lai, Kathleen Riley, Andrew Cai, John M. Leong, and Ira M. Herman

PDF

Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages, Jinhee Lee, Teresa Repasy, Kadamba Papavinasasundaram, Christopher M. Sassetti, and Hardy Kornfeld

Link

Editorial overview, Frances Lund and Janet Stavnezer

PDF

Recombination Phenotypes of Escherichia Coli greA Mutants, Anthony R. Poteete

Link

AID binds cooperatively with UNG and Msh2-Msh6 to Ig switch regions dependent upon the AID C terminus, Sanjay Ranjit, Lyne Khair, Erin K. Linehan, Anna J. Ucher, Mrinmay Chakrabarti, Carol E. Schrader, and Janet Stavnezer

PDF

Extensive genome-wide variability of human cytomegalovirus in congenitally infected infants, Nicholas Renzette, Bornali Bhattacharjee, Jeffrey D. Jensen, Laura L. Gibson, and Timothy F. Kowalik

PDF

A novel zinc binding system, ZevAB, is critical for survival of nontypeable Haemophilus influenzae in a murine lung infection model, Charles V. Rosadini, Jeffrey D. Gawronski, Daniel Raimunda, José M Argüello, and Brian J. Akerley

Link

Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells, Ori Staszewski, Richard E. Baker, Anna J. Ucher, Raygene Martier, Janet Stavnezer, and Jeroen E. J. Guikema

Link

Complex regulation and function of activation-induced cytidine deaminase, Janet Stavnezer

PDF

Regulation of Humoral Immunity by Pim Kinases: A Dissertation, Kristen N. Willems

PDF

ArcA-regulated glycosyltransferase lic2B promotes complement evasion and pathogenesis of nontypeable Haemophilus influenzae, Sandy M. S. Wong, Frank St. Michael, Andrew Cox, Sanjay Ram, and Brian J. Akerley

PDF

The Role of PC4 in Oxidative Stress: A Dissertation, Lijian Yu

Publications from 2010

PDF

Cross-Talk Between Factors Involved in mRNA Translation and Decay: A Dissertation, Shubhendu Ghosh

Link

p53 represses class switch recombination to IgG2a through its antioxidant function, Jeroen E. J. Guikema, Carol E. Schrader, Michael H. Brodsky, Erin K. Linehan, Adam Richards, Nahla El Falaky, Daniel H. LI, Hayla Karen Sluss, Eva Szomolanyi-Tsuda, and Janet Stavnezer

Link

The role of Apex2 in class-switch recombination of immunoglobulin genes, Jeroen E. J. Guikema, Janet Stavnezer, and Carol E. Schrader

Link

Mapping of switch recombination junctions, a tool for studying DNA repair pathways during immunoglobulin class switching, Janet Stavnezer, Andrea Bjorkman, Likun Du, Alberto Cagigi, and Qiang Pan-Hammarstrom

Publications from 2008

PDF

Newcastle Disease Virus Virulence: Mechanism of the Interferon Antagonistic Activity of the V Protein and Characterization of a Putative Virulence-Specific Antibody to the Attachment Protein: a dissertation, Judith G. Alamares

PDF

Magnetic Resonance Imaging of the Rat Retina: a Dissertation, Govind Bhagavatheeshwaran

PDF

Role of Disulfide Bond Rearrangement in Newcastle Disease Virus Entry: A Dissertation, Surbhi Jain

PDF

Role of Host Cellular Membrane Raft Domains in the Assembly and Release of Newcastle Disease Virus: A Dissertation, Jason P. Laliberte

PDF

Molecular Mechanisms of Neuropeptide Secretion from Neurohypophysial Terminals: a Dissertation, James M. McNally

PDF

Modulation of Voltage-Gated N-Type Calcium Channels by G Protein-Coupled Receptors Involves Lipids and Proteins: A Dissertation, Tora Mitra Ganguli

PDF

Modulation of Neuropeptide Release via Voltage-Dependent and -Independent Signaling in Isolated Neurohypophysial Terminals: a Dissertation, Cristina M. Velazquez-Marrero

Publications from 2007

PDF

Collagen and Fibrin Bioplymer Microthreads for Bioengineered Ligament Generation: a Dissertation, Kevin Cornwell

PDF

Transcript-Specific Cytoplasmic Degradation of YRA1 Pre-mRNA Mediated by the Yeast EDC3 Protein: A Dissertation, Shuyun Dong

File

Data from: PTC124 Targets Genetic Disorders Caused by Nonsense Mutations, Allan Jacobson, Phyllis Spatrick, and Feng He

PDF

Surface of Yersinia pestis: LCRV, F1 Production, Invasion and Oxygen: A Dissertation, Kimberly Lea Pouliot

PDF

Modulation of Cav1.3 L-Type Calcium Channels by Arachidonic Acid and Muscarinic M1 Receptors: A Dissertation, Mandy L. Roberts-Crowley

PDF

Interaction of a Mammalian Virus with Host RNA Silencing Pathways: A Dissertation, Bradford Michael Stadler

Publications from 2006

Link

Intracellular accumulation of a 46 kDa species of mouse prion protein as a result of loss of glycosylation in cultured mammalian cells, Subhabrata Biswas, Jan P.M. Langeveld, Donald J. Tipper, and Shan Lu

PDF

Characterization of the Relationship Between Measles Virus Fusion, Receptor Binding, and the Virus-Specific Interaction Between the Hemagglutinin and Fusion Glycoproteins: a Dissertation, Elizabeth Ann Corey

PDF

Requirements for Assembly and Release of Newcastle Disease Virus-Like Particles: A Dissertation, Homer Dadios Pantua

PDF

Rb Inactivation Leads to E2F1-mediated DNA Double Strand Break Accumulation: A Dissertation, Mary Theresa Pickering

PDF

Regulation of Contractility by Adenosine A1 and A2A Receptors in the Murine Heart: Role of Protein Phosphatase 2A: A Dissertation, Eugene I. Tikh

Publications from 2005

PDF

Characterization of the Interaction Between the Attachment and Fusion Glycoproteins Required for Paramyxovirus Fusion: a Dissertation, Vanessa R. Melanson

Publications from 2004

PDF

Prevention of Oxidative Damage by Yeast and Human OXR1: A Dissertation, Nathan Andrew Elliott

PDF

Pathways Linking Deregulated Proliferation to Apoptosis: a Dissertation, Harry A. Rogoff

Publications from 2002

PDF

A Characterization of Substrates and Factors Involved in Yeast Nonsense-Mediated mRNA Decay: A Dissertation, Jonathan Philip Belk

Link

Kre1p, the plasma membrane receptor for the yeast K1 viral toxin, Frank Breinig, Donald J. Tipper, and Manfred J. Schmitt

PDF

The Role of Human Cytomegalovirus Immediate Early Proteins in Cell Growth Control: A Dissertation, Jonathan Patrick Castillo

Publications from 2001

PDF

Modulation of N-type Calcium Channels in Rat Superior Cervical Ganglion Neurons: A Dissertation, Curtis F. Barrett

Publications from 2000

PDF

CIS/SOCS Proteins in Growth Hormone Action: A Dissertation, Ling Du

PDF

A Study on the Cellular Localization of Factors Involved in Yeast Nonsense-Mediated mRNA Decay and their Mechanisms of Control on Nonsense mRNA Translation: a Dissertation, Alan Baer Maderazo

Publications from 1999

PDF

A novel membrane protein influencing cell shape and multicellular swarming of Proteus mirabilis, Nicole A. Hay, Donald J. Tipper, Daniel Gygi, and Colin Hughes

PDF

mRNA Poly(A) tail: a 3' Enhancer of Translational Initiation: a Thesis, David Munroe

PDF

Mechanisms of Newcastle Disease Virus-Mediated Membrane Fusion: A Dissertation, Judith Stone-Hulslander

Publications from 1998

PDF

Transmembrane protein insertion orientation in yeast depends on the charge difference across transmembrane segments, their total hydrophobicity, and its distribution, Carol A. Harley, Jonathan A. Holt, Rhiannon Turner, and Donald J. Tipper

Publications from 1997

PDF

A nonswarming mutant of Proteus mirabilis lacks the Lrp global transcriptional regulator, Nicole A. Hay, Donald J. Tipper, Daniel Gygi, and Colin Hughes

Publications from 1996

Link

Cell cycle studies on the mode of action of yeast K28 killer toxin, Manfred J. Schmitt, Petra Klavehn, Jing Wang, Inge Schonig, and Donald J. Tipper

Publications from 1995

Link

Sequence of the M28 dsRNA: preprotoxin is processed to an alpha/beta heterodimeric protein toxin, Manfred J. Schmitt and Donald J. Tipper

Publications from 1994

Link

Use of beta-lactamase as a secreted reporter of promoter function in yeast, Charles P. Cartwright, Yu Li, Yun Song Zhu, Yoon Se Kang, and Donald J. Tipper

PDF

Analysis of Temperature Sensing in Yersinia pestis: A Dissertation, Nancy Palme Hoe

PDF

Transcriptional Regulation by the SACCHAROMYCES CEREVISIAE Centromere-Binding Protein CP1: a Dissertation, Kevin F. O'Connell

PDF

A Mutational Analysis of Structural Determinants Within the Newcastle Disease Virus Fusion Protein: a Dissertation, Julie N. Reitter

PDF

Signal Transduction Mechanisms for the Stimulation of Lipolysis by Growth Hormone: A Dissertation, Rupert G. Yip

Publications from 1993

PDF

Genetic Analysis of the Saccharomyces Cerevisiae Centromere-Binding Protein CP1: a Thesis, Daniel C. Masison

PDF

Regulation of IgA Class Switch Recombination in the I.29μ B Cell Lymphoma by Cytokines and Inhibitors of Poly(ADP-ribose) Polymerase: A Thesis, Penny E. Shockett

Link

Suppression of a dominant G-protein beta-subunit mutation in yeast by G alpha protein expression, Meng Zhang and Donald J. Tipper

Publications from 1992

Link

Kex2-dependent processing of yeast K1 killer preprotoxin includes cleavage at ProArg-44, Yun Song Zhu, Xia Ying Zhang, Charles P. Cartwright, and Donald J. Tipper

Publications from 1991

PDF

Virus-Lymphocyte Interactions: Virus Expression Is Differentially Modulated by B Cell Activation Signals: A Dissertation, Madelyn R. Schmidt

Link

Yeast dsRNA viruses: replication and killer phenotypes, Donald J. Tipper and Manfred J. Schmitt

PDF

Regulation of Transcription of Mouse Immunoglobulin Germ-Line γ1 RNA: Structural Characterization of Germ-Line γ1 RNA and Molecular Analysis of the Promoter: A Dissertation, Minzhen Xu

Publications from 1990

PDF

Regulation of β-Adrenergic-Induced Protein Phosphorylation in the Myocardium: A Dissertation, Edward E. George

PDF

The Stimulation of Luteinizing Hormone Secretion from Anterior Pituitary Cells in Culture by Substance P: A Dissertation, Maureen Shamgochian

Publications from 1989

PDF

Structural Determinants of mRNA Turnover in Yeast: a Thesis, David Herrick

Publications from 1987

Link

The major acid-soluble proteins of Bacillus subtilis spores: partial amino acid sequence and forespore location of their mRNAs, Hans Blom, Robert Morse, J. Mandelkorn, M. Arnaud, R. Warburg, and Donald J. Tipper

Publications from 1986

Link

Expression of a cDNA derived from the yeast killer preprotoxin gene: implications for processing and immunity, Steven D. Hanes, Virginia E. Burn, Stephen L. Sturley, Donald J. Tipper, and Kieth A. Bostian

Link

Mapping of functional domains within the Saccharomyces cerevisiae type 1 killer preprotoxin, Stephen L. Sturley, Quentin Elliot, JoAnn LeVitre, Donald J. Tipper, and Keith A. Bostian

Publications from 1985

PDF

Transcriptional control of synthesis of acid-soluble proteins in sporulating Bacillus subtilis, W. Charles Johnson, Inga Mahler, Kent Phillips, and Donald J. Tipper

Link

Mode of action of beta-lactam antibiotics, Donald J. Tipper

Publications from 1984

Link

Sequence of the preprotoxin dsRNA gene of type I killer yeast: multiple processing events produce a two-component toxin, Keith A. Bostian, Quentin Elliott, Howard Bussey, Virginia Burn, Al Smith, and Donald J. Tipper

Link

Virus-like particle capsid proteins encoded by different L double-stranded RNAs of Saccharomyces cerevisiae: their roles in maintenance of M double-stranded killer plasmids, Mohamed El-Sherbeini, Donald J. Tipper, Diane J. Mitchell, and Keith A. Bostian

Link

Cloning of an unstable spoIIA-tyrA fragment from Bacillus subtilis, Inga Mahler, R. Warburg, Donald J. Tipper, and H. O. Halvorson

PDF

Double-stranded ribonucleic acid killer systems in yeasts, Donald J. Tipper and Kieth A. Bostian

Link

Cloning the Bacillus subtilis 168 aroC gene encoding dehydroquinase, R. J. Warburg, Inga Mahler, Donald J. Tipper, and H. O. Halvorson

Publications from 1983

PDF

Yeast killer dsRNA plasmids are transcribed in vivo to produce full and partial-length plus-stranded RNAs, Keith A. Bostian, Virginia E. Burn, S. Jayachandran, and Donald J. Tipper

Link

A glycosylated protoxin in killer yeast: models for its structure and maturation, Keith A. Bostian, S. Jayachandran, and Donald J. Tipper

PDF

Secretion of Saccharomyces cerevisiae killer toxin: processing of the glycosylated precursor, H. Bussey, D. Saville, D. Greene, Donald J. Tipper, and Keith A. Bostian

Publications from 1981

PDF

Coat protein synthesis during sporulation of Bacillus subtilis: immunological detection of soluble precursors to the 12,200-dalton spore coat protein, Robert C. Goldman and Donald J. Tipper

PDF

Acid-soluble spore proteins of Bacillus subtilis, W. C. Johnson and Donald J. Tipper

PDF

Comparison of various properties of low-molecular-weight proteins from dormant spores of several Bacillus species, Katherine Yuan, W. Charles Johnson, Donald J. Tipper, and Peter Setlow

Publications from 1980

Link

Translational analysis of the killer-associated virus-like particle dsRNA genome of S. cerevisiae: M dsRNA encodes toxin, Keith A. Bostian, James E. Hopper, Davis T. Rogers, and Donald J. Tipper

PDF

Encapsidation of yeast killer double-stranded ribonucleic acids: dependence of M on L, Keith A. Bostian, Joyce A. Sturgeon, and Donald J. Tipper