A Nutrition-Longevity Tradeoff Enforced by Innate Immunity
Department of Microbiology and Physiological Systems; Program in Innate Immunity; Graduate School of Biomedical Sciences
Response or Comment
Immunology and Infectious Disease | Microbiology
Dietary restriction (DR) extends lifespan in multiple animal species, but the underlying molecular mechanisms remain poorly understood. A recent study published in Cell Metabolism by Wu et al. (2019) shows that DR represses an evolutionarily conserved p38 MAPK pathway involved in innate immunity, leading to diminished expression of p38 MAPK-regulated genes and extended lifespan.
DOI of Published Version
Mol Cell. 2019 Jun 6;74(5):864-865. doi: 10.1016/j.molcel.2019.05.012. Link to article on publisher's site
Wani KA, Goswamy D, Irazoqui JE. (2019). A Nutrition-Longevity Tradeoff Enforced by Innate Immunity. Microbiology and Physiological Systems Publications. https://doi.org/10.1016/j.molcel.2019.05.012. Retrieved from https://escholarship.umassmed.edu/maps_pubs/71