Title

A Nutrition-Longevity Tradeoff Enforced by Innate Immunity

UMMS Affiliation

Department of Microbiology and Physiological Systems; Program in Innate Immunity; Graduate School of Biomedical Sciences

Publication Date

2019-06-06

Document Type

Response or Comment

Disciplines

Immunology and Infectious Disease | Microbiology

Abstract

Dietary restriction (DR) extends lifespan in multiple animal species, but the underlying molecular mechanisms remain poorly understood. A recent study published in Cell Metabolism by Wu et al. (2019) shows that DR represses an evolutionarily conserved p38 MAPK pathway involved in innate immunity, leading to diminished expression of p38 MAPK-regulated genes and extended lifespan.

DOI of Published Version

10.1016/j.molcel.2019.05.012

Source

Mol Cell. 2019 Jun 6;74(5):864-865. doi: 10.1016/j.molcel.2019.05.012. Link to article on publisher's site

Journal/Book/Conference Title

Molecular cell

Related Resources

Link to Article in PubMed

PubMed ID

31173721

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