Nervous system control of intestinal host defense in C. elegans
Department of Microbiology and Physiological Systems; Program in Innate Immunity; Graduate School of Biomedical Sciences
Immunology and Infectious Disease | Microbiology | Neuroscience and Neurobiology
Interplay between the nervous and immune systems is critical for homeostasis, and its dysfunction underlies pathologies such as multiple sclerosis, autism, leukemia, and inflammation. The nematode Caenorhabditis elegans provides an opportunity to define evolutionarily conserved mechanisms of regulation of host innate immunity and inflammation in a genetically tractable whole-animal system. In the past few years, the C. elegans nervous system has emerged as an integral part of host defense against pathogens, acting through diverse mechanisms to repress or induce protective transcriptional responses to infection in distal tissues. In this review, we discuss current knowledge of the mechanisms through which the C. elegans nervous system controls the expression of host defense genes in the intestinal epithelium. Although still incomplete, the insights derived from such work have broad implications for neural regulation of epithelial function at mucosal barriers in higher organisms in health and disease.
DOI of Published Version
Curr Opin Neurobiol. 2019 Nov 29;62:1-9. doi: 10.1016/j.conb.2019.11.007. Link to article on publisher's site
Current opinion in neurobiology
Wani KA, Goswamy D, Irazoqui JE. (2019). Nervous system control of intestinal host defense in C. elegans. Microbiology and Physiological Systems Publications. https://doi.org/10.1016/j.conb.2019.11.007. Retrieved from https://escholarship.umassmed.edu/maps_pubs/70